Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 279, Issue 4 42-4, 2000, Pages

  Gupta, Sanjeev ^a   Rajvanshi, Pankaj ^a   Malhi, Harmeet ^a   Slehria, Sanjeev ^a   Sokhi, Rana P ^a   Vasa, Srinivasa R G ^a   Dabeva, Mariana ^a   Shafritz, David A ^a   Kerr, Andrew ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Gene expression; Hepatocyte; Injury; Ischemia; Vasodilatation

Indexed keywords

GAMMA GLUTAMYLTRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL TRANSPLANTATION; CONTROLLED STUDY; DNA SYNTHESIS; GAP JUNCTION; LIVER INJURY; LIVER ISCHEMIA; LIVER SINUSOID; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VASODILATATION;

EID: 0033712735     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.279.4.g815     Document Type: Article

References (49)

1. Tissue glutathione
2. Expression of H-ras and c-myc protooncogenes in isolated gamma-glutamyl transpeptidase-positive rat hepatocytes and in hepatocellular carcinomas induced by diethylnitrosamine
3. Heterogeneous lobular distribution of hepatocytes expressing acute-phase genes during the acute inflammatory reaction
4. Ability of partial hepatectomy to induce gamma-glutamyltranspeptidase in regenerated and transplanted hepatocytes of Fischer 344 and Wistar-Furth rats
5. Functional characterization of the rat gamma-glutamyl transpeptidase promoter that is expressed and regulated in the liver and hepatoma cells
6. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
7. Activation, proliferation, and differentiation of progenitor cells into hepatocytes in the D-galactosamine model of liver regeneration
8. Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver
9. Triiodothyronine decreases gammaglutamyltranspeptidase expression in cultured rat hepatocytes
10. Modulation of gamma-glutamyltranspeptidase in normal rat hepatocytes in culture by cell density, epidermal growth factor and agents which alter cell differentiation
11. Paclitaxel shows cytotoxic activity in human hepatocellular carcinoma cell lines
12. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
13. Differential decrease in connexin 32 expression in ischemic and nonischemic regions of rat liver during ischemia/reperfusion
14. Structural, functional, and clinical aspects of gamma-glutamyltransferase
15. Induction of an acute phase response in rats stimulates the expression of alpha 1(I) procollagen messenger ribonucleic acid in their livers. Possible role of interleukin- 6
16. Permanent engraftment and function of hepatocytes delivered to the liver: Implications for gene therapy and liver repopulation
17. Hepatocyte transplantation: Emerging insights into mechanisms of liver repopulation and their relevance to potential therapies
18. 4 treatment and hepatocyte growth factor infusion
19. Integration and proliferation of transplanted cells in hepatic parenchyma following D-galactosamine-induced acute injury in F 344 rats
20. Integration of transplanted hepatocytes in host liver plates demonstrated with dipeptidyl peptidase IV deficient rats
21. Entry and integration of transplanted hepatocytes in liver plates occur by disruption of hepatic sinusoidal endothelium
22. Hepatocytes exhibit superior transgene expression after transplantation into liver and spleen compared with peritoneal cavity or dorsal fat pad: Implications for hepatic gene therapy
23. The same gamma-glutamyl transpeptidase RNA species is expressed in fetal liver, hepatic carcinomas, and rasT24-transformed rat liver epithelial cells
24. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine
25. Glycohydrolases as markers of hepatic ischemia-reperfusion injury and recovery
26. Studies on dipeptidyl(amino)peptidase IV (glycyl-proline naphthylamidase)
27. Catalase
28. Purification and transplantation of hepatocytes from livers of carcinogen-treated rats
29. Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species
30. Differentiation-specific regulation of transgene expression in a diploid epithelial cell line derived from the normal F 344 rat liver
31. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinemia type 1
32. Hepatic oval cells express the hematopoietic stem cell marker Thy- 1 in the rat
33. Neoplastic phenotype of gap-junctional intercellular communication-deficient WB rat liver epithelial cells and its reversal by forced expression of connexin 32
34. Efficacy and safety of repeated hepatocyte transplantation for significant liver repopulation in rodents
35. Studies of liver repopulation using the dipeptidyl peptidase IV deficient rat and other rodent recipients: Cell size and structure relationships regulate capacity for increased transplanted hepatocyte mass in the liver lobule
36. Ploidy-based fractionation of rat hepatocytes with varying metabolic potential, proliferative capacity and retroviral gene transfer
37. Replacement of diseased mouse liver by hepatic cell transplantation
38. Histochemical and ultrastruc-rural demonstration of γ-glutamyl transpeptidase activity
39. Use of enzymes for the diagnosis of alcohol-related organ damage
40. Effects of short-term and prolonged aerogenic hypoxia on gamma-glutamyl transpeptidase activity in the brain, liver, and biological fluids of young rats
41. γ-Glutamyltranspeptidase-positive rat hepatocytes are protected from GSH depletion, oxidative stress and reversible alterations of collagen receptors
42. The effects of epidermal growth factor and the state of confluence on enzymatic activities of cultured rat liver epithelial cells
43. Cell proliferation and advancement of hepatocarcinogenesis in the rat are associated with a decrease in connexin 32 expression
44. Clofibrate-induced neoplastic development in the rat liver is associated with decreased connexin 32 expression but not with a coordinated shift in expression of marker enzymes
45. Changes in plasma γ-glutamyl transferase activity associated with alterations in drug metabolism in man
46. A method for the comparative study of replicative DNA synthesis in GGT-positive and GGT-negative hepatocytes in primary culture isolated from carcinogen-treated rats
47. Increased liver engraftment of transplanted hepatocytes following selective hepatocyte injury
48. Effect of ovariectomy and sex hormones replacement on tumour marker enzymes under administration of chemical carcinogens in the rat
49. Modulation of connexins during differentiation of oval cells into hepatocytes