Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis

Gastroenterology

Volumn 119, Issue 6, 2000, Pages 1720-1730

  De Vree, J MarleenL ^a   Ottenhoff, Roel ^a   Bosma, Piter J ^a   Smith, Alexander J ^a   Aten, Jan ^a   Oude Elferink, Ronald P J ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; BILE SALT; PHOSPHOLIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TRANSPLANTATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; IMMUNOHISTOCHEMISTRY; INTRAHEPATIC CHOLESTASIS; LIPID BILE LEVEL; LIPOGENESIS; LIVER CELL; LIVER CELL DAMAGE; LIVER DISEASE; LIVER TUMOR; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0034466173     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2000.20222     Document Type: Article

References (25)

1. Liver regeneration
2. Hepatic stem cells in liver regeneration
3. Replacement of diseased mouse liver by hepatic cell transplantation
4. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I
5. Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes
6. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation
7. Intrahepatic transplantation of normal hepatocytes prevents Wilson's disease in Long-Evans cinnamon rats
8. Zonal regulation of gene expression during liver regeneration of urokinase transgenic mice
9. Adenovirus-mediated gene therapy in a mouse model of hereditary tyrosinemia type I
10. Therapeutic trials in the murine model of hereditary tyrosinaemia type I: A progress report
11. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
12. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis
13. Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2(-/-) mice
14. Class III P-glycoproteins mediate the formation of lipoprotein X in the mouse
15. High-yield preparation of isolated rat liver parenchymal cells: A biochemical and fine structural study
16. Effects of ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene
17. Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse
18. Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy
19. Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis
20. Entry and integration of transplanted hepatocytes in rat liver plates occur by disruption of hepatic sinusoidal endothelium
21. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis
22. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis
23. Ursodeoxycholic acid therapy in pediatric patients with progressive familial intrahepatic cholestasis
24. Human gene therapy
25. Liver-directed gene transfer vectors