Rapid clearance of transplanted hepatocytes from pulmonary capillaries in rats indicates a wide safety margin of liver repopulation and the potential of using surrogate albumin particles for safety analysis

Journal of Hepatology

Volumn 30, Issue 2, 1999, Pages 299-310

  Rajvanshi, Pankaj ^c   Fabrega, Alfredo ^a   Bhargava, Kuldeep K ^c   Kerr, Andrew ^c   Pollak, Raymond ^b   Blanchard, Jacqueline ^b   Palestro, Christopher J ^c   Gupta, Sanjeev ^c  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c NONE

Author keywords

Hepatocyte; Liver; Lungs; Macroaggregated albumin; Transplantation

Indexed keywords

ALBUMIN;

ANIMAL CELL; ARTICLE; CELL TRANSPLANTATION; FUNCTIONAL ASSESSMENT; LIVER CELL; LUNG CAPILLARY; NONHUMAN; PRIORITY JOURNAL; RAT; SAFETY; TISSUE DISTRIBUTION;

EID: 0032909452     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(99)80077-4     Document Type: Article

References (38)

1. Gupta S, Rajvanshi P, Bhargava KK, Kerr A. Hepatocyte transplantation: progressing toward liver repopulation. Boyer JL, Ockner RL, . Progress in Liver Diseases, Vol. 14. 1996;199-222 WB Saunders, Philadelphia.
2. Gupta S, Roy Chowdhury N, Jagtiani R, Gustin K, Shafritz DA, Roy Chowdhury J, et al. A novel system for transplantation of isolated hepatocytes utilizing HBsAg producing transgenic donor cells. Transplantation. 50:1990;472-475.
3. Gupta S, Aragona E, Vemuru RP, Bhargava K, Burk RD, Roy Chowdhury J. Permanent engraftment and function of hepatocytes delivered to the liver: implications for gene therapy and liver repopulation. Hepatology. 14:1991;144-149.
4. Ponder KP, Gupta S, Leland F, Darlington G, Finegold M, De-Mayo J, et al. Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Natl Acad Sci USA. 88:1991;1217-1221.
5. Gupta S, Rajvanshi P, Lee C-D. Integration of transplanted hepatocytes in host liver plates demonstrated with dipeptidyl peptidase IV deficient rats. Proc Natl Acad Sci USA. 92:1995;5860-5864.
6. Gupta S, Vemuru RP, Lee C-D, Yerneni P, Aragona E, Burk RD. Hepatocytes exhibit superior transgene expression after transplantation into liver and spleen compared with peritoneal cavity or dorsal fat pad: implications for hepatic gene therapy. Hum Gene Ther. 5:1994;959-967.
7. Rajvanshi P, Kerr A, Bhargava KK, Burk RD, Gupta S. Studies of liver repopulation using the dipeptidyl peptidase IV deficient rat and other rodent recipients: cell size and structure relationships regulate capacity for increased transplanted hepatocyte mass in the liver lobule. Hepatology. 23:1996;482-496.
8. Rajvanshi P, Kerr A, Bhargava KK, Burk RD, Gupta S. Studies in rodents to demonstrate efficacy and safety of repeated hepatocyte transplantation for significant liver repopulation. Gastroenterology. 111:1996;1092-1102.
9. Gupta S, Yerneni P, Vemuru RP, Lee CD, Yellin EL, Bhargava KK. Studies on the safety of intrasplenic hepatocyte transplantation: relevance to ex-vivo gene therapy and liver repopulation in acute hepatic failure. Hum Gene Ther. 4:1993;249-257.
10. Selden AC, Gupta S, Johnstone R, Hodgson HJF. The pulmonary vascular bed as a site for implantation of isolated liver cells in inbred rats. Transplantation. 38:1984;81-83.
11. Sandbichler P, Then P, Vogel W, Erhart R, Dictze O, Philadelphy H, et al. Hepatocellular transplantation into the lung for temporary support of acute liver failure in the rat. Gastroenterology. 102:1992;605-609.
12. Sandbichler P, Erhart R, Herbst P, Vogel W, Herold M, Dietze O, et al. Hepatocellular transplantation into the lung in chronic liver failure following bile duct obstruction in the rat. Cell Transplant. 3:1994;409-412.
13. Fabrega AJ, Bommineni VR, Blanchard J, Tetali S, Rivas PA, Pollak R, et al. Amelioration of analbuminemia by transplantation of allogeneic hepatocytes in tolerized rats. Transplantation. 59:1995;1362-1364.
14. 99mTc or endogenous dipeptidyl peptidase IV activity. Cell Transplant. 6:1997;377-386.
15. Rajvanshi P, Bhargava KK, Afriye M, Camaya M, Gagandeep S, Vasa SRG, et al. Human serum albumin microspheres approximate initial organ-specific biodistributions of transplanted hepatocytes and are effective cell surrogates for safety studies. Cell Transplant. 7:1998;275-283.
16. Lee SH, Fisher B. Portacaval shunt in the rat. Surgery. 50:1961;668-672.
17. Bensley CM. Comparison of methods for demonstrating glycogen microscopically. Stain Technol. 14:1930;47-52.
18. Haggart GE, Walker AM. The physiology of pulmonary embolism as disclosed by quantitative occlusion of the pulmonary artery. Arch Surg. 6:1923;764-783.
19. Ostensen J, Hede R, Myreng Y, Ege T, Holtze E. Intravenous injection of Albunex microspheres causes thromboxane mediated pulmonary hypertension in pigs, but not in monkeys or rabbits. Acta Physiol Scand. 144:1992;307-315.
20. Feinstein SB, Cheirif J, Ten Cate FJ, Silverman PR, Heidenreich PA, Dick C, et al. Safety and efficacy of a new transpulmonary ultrasound contrast agent: initial multicenter results. J Am Coll Cardiol. 16:1990;316-324.
21. Ten Cate FJ, Widisky P, Cornel JH, Waldstein DJ, Serruys PW, Waaler A. Intracoronary Albunex. Its effects on left ventricular hemodynamics, function, and coronary sinus flow in humans. Circulation. 88:1993;2123-2127.
22. Okuda K, Suzuki K, Musha H, Arimuzu N. Percutaneous transhepatic catheterization of the portal vein for the study of portal hemodynamics and shunts. A preliminary report. Gastroenterology. 73:1977;279-284.
23. Ohnishi K, Chin N, Saito M, Tanaka H, Terabayashi H, Nakayama T, et al. Portographic opacification of hepatic veins and (anomalous) anastomoses between the portal and hepatic veins in cirrhosis: indication of extensive intrahepatic shunts. Am J Gastroenterol. 81:1986;975-978.
24. Ohnishi K, Saito M, Sato S, Terabayashi H, Iida S, Nomura F, et al. Portal hemodynamics in idiopathic portal hypertension (Banti's syndrome). Comparison with chronic persistent hepatitis and normal subjects. Gastroenterology. 92:1987;751-758.
25. Ohnishi K, Chin N, Sugita S, Saito M, Tanaka H, Terabayashi H, et al. Quantitative aspects of portal-systemic and arteriovenous shunts within the liver in cirrhosis. Gastroenterology. 93:1987;129-134.
26. Nomura F, Ohnishi K, Terabayashi H, Nakai T, Isobe K, Takekoshi K, et al. Effect of intrahepatic portal-systemic shunting on hepatic ammonia extraction in patients with cirrhosis. Hepatology. 20:1994;1478-1481.
27. Chin N, Ohnishi K, Iida S, Nomura F. Role of intrahepatic portal-systemic shunts in the reduction of portal blood supply to liver cells in cirrhosis. Am J Gastroenterol. 83:1988;718-722.
28. Walser EM, Harris VM, Harman JT, Park HM, Siddiqui AR. Quantification of intrahepatic portosystemic shunting after placement of a transjugular intrahepatic portosystemic shunt. J Vasc Intervent Radiol. 7:1996;263-267.
29. Hoefs JC, Rcynolds TB, Pare P, Sakimura I. A new method for the measurement of intrahepatic shunts. J Clin Lab Med. 103:1984;446-461.
30. 99mTc-labeled macroaggregated albumin in intrahepatic arterial chemotherapy. Am J Roentgenol. 139:1982;711-715.
31. Kaplan WD, Come SE, Takvorian RW, Laffin SM, Gelman RS, Weiss GR, et al. Pulmonary uptake of technetium 99m macroag-gregated albumin: a predictor of gastrointestinal toxicity during hepatic artery perfusion. J Clin Oncol. 2:1984;1266-1269.
32. Sigurdson ER, Ridge JA, Kemeny N, Daly JM. Tumor and liver drug uptake following hepatic artery and portal vein infusion. J Clin Oncol. 5:1987;1836-1840.
33. 99m macroaggregated albumin scan in hepatocellular carcinoma. Cancer Chemother Pharmacol. 33:1994;S33-S36.
34. Nagai T, Jimbo M, Sano K. Cerebro-pulmonary scan using macroaggregated albumin as a quantitation of intracerebral arteriovenous shunting. J Nucl Med. 8:1967;709-722.
35. Taplin GV, Jhonson DE, Kennady JC, Dore EK, Poe ND, Swanson LA, et al. Aggregated albumin labeled with various radioisotopes, radioactive pharmaceuticals. US-AEC, CONF-65. 1111:1966;525.
36. 113m In macroaggregated albumin: correlation of the perfusion image with clinical, angiographic, surgical, and histologic findings. Am Heart J. 89:1975;708-715.
37. Feiring AJ, Bruch P, Husayni TS, Kirchner PT, Marcus ML. Premortem assessment of myocardial area at risk with the use of intracoronary technetium macroaggregated albumin and gated nuclear imaging. Circulation. 73:1986;551-561.
38. Walday P, Tolleshaug H, Gjoen T, Kindberg GM, Berg T, Skotland T, et al. Biodistributions of air-filled albumin microspheres in rats and pigs. Biochem J. 299:1994;437-443.