Thrombospondin-1 inhibits Kaposi's sarcoma (KS) cell and HIV-1 TAT- induced angiogenesis and is poorly expressed in KS lesions

Journal of Pathology

Volumn 188, Issue 1, 1999, Pages 76-81

  Taraboletti, Giulia ^a   Benelli, Roberto ^b   Borsotti, Patrizia ^a   Rusnati, Marco ^c   Presta, Marco ^c   Giavazzi, Raffaella ^a   Ruco, Luigi ^d   Albini, Adriana ^b  

^a MARIO NEGRI INST PHARMACOL RES   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

AIDS; Angiogenesis; Kaposi's sarcoma; Thrombospondin; Vascular tumours

Indexed keywords

ALPHA INTERFERON; HEMOGLOBIN; MATRIGEL; THROMBOSPONDIN 1; TRANSACTIVATOR PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MOTILITY; CELL PROLIFERATION; CHEMOTAXIS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPOSI SARCOMA; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR ENDOTHELIUM;

ANIMALS; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE PRODUCTS, TAT; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; SARCOMA, KAPOSI; THROMBOSPONDIN 1; TUMOR CELLS, CULTURED;

EID: 0032893659     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199905)188:1<76::AID-PATH312>3.0.CO;2-A     Document Type: Article

References (39)

1. Gallo RC. Some aspects of the pathogenesis of HIV-1-associated Kaposi's sarcoma. J Natl Cancer Inst Monogr 1998; 23: 55-57.
2. Nickoloff BJ, Foreman KE. Charting a new course through the chaos of KS (Kaposi's sarcoma). Am J Pathol 1996; 148: 1323-1329.
3. Fife K, Bower M. Recent insights into the pathogenesis of Kaposi's sarcoma. Br J Cancer 1996; 73: 1317-1322.
4. Albini A, Fontanini G, Masiello L, et al. Angiogenic potential in vivo by Kaposi's sarcoma cell-free supernatants and HIV-1 tat product: inhibition of KS-like lesions by tissue inhibitor of metalloproteinase-2. AIDS 1994; 8: 1237-1244.
5. Ensoli B, Buonaguro L, Barillari G, et al. Release, uptake, and effects of extracellular human immunodeficiency virus type I Tat protein on cell growth and viral transactivation. J Virol 1993; 67: 277-287.
6. Albini A, Soldi R, Giunciuglio D, et al. The angiogenesis induced by HIV-Tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells. Nature Med 1996; 2: 1371-1375.
7. Albini A, Benelli R, Presta M, et al. HIV-tat protein is a heparin-binding angiogenic growth factor. Oncogene 1996; 12: 289-297.
8. Hofman FM, Wright AD, Dohadwala MM, Wong-Staal F, Walker SM. Exogenous tat protein activates human endothelial cells. Blood 1993; 82: 2774-2780.
9. Albini A, Barillari G, Benelli R, Gallo RC, Ensoli B. Angiogenic properties of human immunodeficiency virus type I Tat protein. Proc Natl Acad Sci U S A 1995; 92: 4838-4842.
10. Ensoli B, Barillari G, Salahuddin SZ, Gallo RC, Wong-Staal F. Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. Nature 1990; 345: 84-86.
11. Ensoli B, Gendelman R, Markham P, et al. Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma. Nature 1994; 371: 674-680.
12. Corallini A, Altavilla G, Pozzi L, et al. Systemic expression of HIV-1 tat gene in transgenic mice induces endothelial proliferation and tumors of different histotypes. Cancer Res 1993; 53: 5569-5575.
13. Vogel J, Hinrich SH, Reynolds RK, Luciw PA, Jay G. The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice. Nature 1988; 335: 606-611.
14. Bornstein P, Sage EH. Thrombospondins. Methods Enzymol 1994; 245: 62-85.
15. Bornstein P. Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin I. J Cell Biol 1995; 130: 503-506.
16. Tuszynski GP, Nicosia RF. The role of thrombospondin-1 in tumor progression and angiogenesis. BioEssays 1996; 18: 71-76.
17. Roberts DD. Regulation of tumor growth and metastasis by thrombospondin-1. FASEB J 1996; 10: 1183-1191.
18. Taraboletti G, Roberts D, Liotta LA, Giavazzi R. Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor. J Cell Biol 1990; 111: 765-772.
19. Good DJ, Polverini PJ, Rastinejad F, et al. A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc Natl Acad Sci U S A 1990; 87: 6624-6628.
20. Guo N, Krutzsch HC, Imman J, Roberts DD. Thrombospondin I and type I repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cells. Cancer Res 1997; 57: 1735-1742.
21. Zabrenetzky VS, Harris CC, Steeg PS, Roberts DD. Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines. Int J Cancer 1994; 59: 191-195.
22. Sheibani N, Frazier WA. Thrombospondin I expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis. Proc Natl Acad Sci U S A 1995; 92: 6788-6792.
23. Dameron KM, Volpert OV, Tainsky MA, Bouck N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 1994; 265: 1582-1584.
24. Taraboletti G, Belotti D, Borsotti P, et al. The 140-kilodalton anti-angiogenic fragment of thrombospondin-1 binds to basic fibroblast growth factor. Cell Growth Differ 1997; 8: 471-479.
25. Thompson EW, Nakamura S, Shima TB, et al. Supernatants of acquired immunodeficiency syndrome-related Kaposi's sarcoma cells induce endothelial cell chemotaxis and invasiveness. Cancer Res 1991; 51: 2670-2676.
26. Passaniti A, Taylor RM, Pili R, et al. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Invest 1992; 67: 519-528.
27. Uccini S, Ruco LP, Monardo F, et al. Co-expression of endothelial cell and macrophage antigens in Kaposi's sarcoma cells. J Pathol 1994; 173: 23-31.
28. Jaffe EA, Ruggiero JT, Leung LLK, Doyle MJ, McKeon-Longo PJ, Mosher DF. Cultured fibroblasts synthesize and secrete thrombospondin and incorporate it into the extracellular matrix. Proc Natl Acad Sci U S A 1983; 149: 3727-3734.
29. Grossfeld GD, Ginsberg DA, Stein JP, et al. Thrombospondin-1 expression in bladder cancer: association with p53 alterations, tumor angiogenesis, and tumor progression. J Natl Cancer Inst 1997; 89: 219-227.
30. Bertin N, Clezardin P, Kubiak R, Frappart L. Thrombospondin-1 and -2 messenger RNA expression in normal, benign, and neoplastic human breast tissue: correlation with prognostic factors, tumor angiogenesis, and fibroblastic desmoplasia. Cancer Res 1997; 57: 396-399.
31. Weiss RA, Whitby D, Talbot S, Kellam P, Boshoff C. Human herpesvirus type 8 and Kaposi's sarcoma. J Natl Cancer Inst Monogr 1998; 23: 51-54.
32. Flore O, Rafii S, Ely S, O'Leary JJ, Hyjek EM, Cesarman E. Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus. Nature 1998; 394: 588-592.
33. Bais C, Santomasso B, Coso O, et al. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature 1998; 391: 86-89.
34. Boshoff C, Endo Y, Collins PD, et al. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. Science 1997; 278: 290-294.
35. RayChaudhury A, Frazier WA, D'Amore PA. Comparison of normal and tumorigenic endothelial cells: differences in thrombospondin production and responses to transforming growth factor-beta. J Cell Sci 1994; 107: 39-46.
36. Fiorelli V, Gendelman R, Samaniego F, Markham PD, Ensoli B. Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells. J Clin Invest 1995; 95: 1723-1724.
37. Morandi V, Lamhamedi Cherradi S-E, Lambert S, Fauvel-Lafeve F, Legrand YJ, Legrand C. Proinflammatory cytokines (interleukin-1β and tumor necrosis factor-α) down-regulate synthesis and secretion of thrombospondin by human endothelial cells. J Cell Physiol 1994; 160: 367-377.
38. Dawson DW, Pearce SFA, Zhong R, Silverstein RL, Frazier WA, Bouck NP. CD36 mediates the in vitro inhibitory effects of thrombospondin-1 on endothelial cells. J Cell Biol 1997; 138: 707-717.
39. Roth WK, Brandstetter H, Stürzl M. Cellular and molecular features of HIV-associated Kaposi's sarcoma. AIDS 1992; 6: 895-913.