Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15

Molecular and Cellular Biology

Volumn 22, Issue 15, 2002, Pages 5405-5418

  Braun, Isabelle C ^a   Herold, Andrea ^a   Rode, Michaela ^a   Izaurralde, Elisa ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; MESSENGER RNA; NUCLEOPORIN; PROTEIN NXF1; PROTEIN P15; PROTEIN TAP; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DIMERIZATION; GENE TRANSLOCATION; METAZOON; NONHUMAN; NUCLEAR PORE; PRIORITY JOURNAL; RNA TRANSPORT;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; CARRIER PROTEINS; CELL LINE; CELL NUCLEUS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PORE COMPLEX PROTEINS; NUCLEAR PROTEINS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; OOCYTES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; RNA-BINDING PROTEINS; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

METAZOA;

EID: 0036315590     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.15.5405-5418.2002     Document Type: Article

References (42)

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6. NXT1 is necessary for the terminal step of Crm1-mediated nuclear export
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12. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
13. NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells
14. TAP/NXF1 belongs to a multigene family of putative RNA export factors with a conserved modular architecture
15. NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila
16. Minimal Rev-responsive element for type 1 human immuno-deficiency virus
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36. Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins
37. The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF1, an ortholog of human TAP/NXF1 and Saccharomyces cerevisiae Mex67p
38. Domains of U4 and U6 snRNAs required for snRNP assembly and splicing complementation in Xenopus oocytes
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40. Small bristles, the Drosophila ortholog of human TAP/NXF1 and yeast Mex67p, is essential for mRNA nuclear export throughout development
41. Two closely related human nuclear export factors utilize entirely distinct export pathways
42. Mex67p of Schizosaccharomyces pombe interacts with Rae1p in mediating mRNA export