Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli muty DNA glycosylase homolog (MYH), in vivo, in the rat brain

Journal of Neurochemistry

Volumn 80, Issue 5, 2002, Pages 928-937

  Lee, Heung Man ^a   Wang, Cheng ^a   Hu, Zhaoyong ^a   Greeley Jr , George H ^a   Makalowski, Wojciech ^c   Hellmich, Helen L ^a   Englander, Ella W ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Blood oxygenation; Cloning; DNA repair; Hypoxia; MutY DNA glycosylase; Rat brain

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANTIOXIDANT; BIOLOGICAL MARKER; COMPLEMENTARY DNA; DNA GLYCOSYLASE MUTY; DNA GLYCOSYLTRANSFERASE; MESSENGER RNA; MITOCHONDRIAL DNA; OXIDIZING AGENT; UNCLASSIFIED DRUG;

ADOLESCENT; AMINO ACID SEQUENCE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD OXYGENATION; BRAIN CORTEX; BRAIN HYPOXIA; CEREBELLUM; DNA DAMAGE; DNA REPAIR; ENERGY METABOLISM; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; BRAIN; CLONING, MOLECULAR; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; DNA, MITOCHONDRIAL; GUANINE; HYPOXIA, BRAIN; IN SITU HYBRIDIZATION; MALE; MOLECULAR SEQUENCE DATA; N-GLYCOSYL HYDROLASES; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; UP-REGULATION;

ANIMALIA; ESCHERICHIA COLI;

EID: 0036312376     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-3042.2002.00774.x     Document Type: Article

References (49)

1. Expression of Kin17 and 8-OxoG DNA glycosylase in cells of rodent and quail central nervous system
2. Stress-induced increase in vasopressin and corticotropin-releasing factor expression in hypophysiotrophic paraventricular neurons
3. Oxidative decay of DNA
4. The free radical theory of aging matures
5. Enzymology of mitochondrial base excision repair
6. Detection of DNA base-excision repair activity for oxidative lesions in adult rat brain mitochondria
7. Early detection of DNA strand breaks in the brain after transient focal ischemia: Implications for the role of DNA damage in apoptosis and neuronal cell death
8. Computational method to predict mitochondrially imported proteins and their targeting sequences
9. Oxidative damage to the c-fos gene and reduction of its transcription after focal cerebral ischemia
10. Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain
11. DNA repair: Caretakers of the genome?
12. Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts
13. Cerebral carbohydrate metabolism during acute hypoxia and recovery
14. Hypoxia-induced mitochondrial and nuclear DNA damage in the rat brain
15. Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice
16. Early decrease of XRCC1, a DNA base excision repair protein, may contribute to DNA fragmentation after transient focal cerebral ischemia in mice
17. In situ detection of AP sites and DNA strand breaks bearing-3′-phosphate termini in ischemic mouse brain
18. In situ detection of neuronal DNA strand breaks using the Klenow fragment of DNA polymerase I reveals different mechanisms of neuron death after global cerebral ischemia
19. Cerebral blood flow and oxygen consumption in the rat in hypoxic hypoxia
20. Mitochondrial DNA synthesis studied autoradiographically in various cell types in vivo
21. Formation of the base modification 8-hydroxyl-2′-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat
22. The C-terminal domain of MutY glycosylase determines the 7,8-dihydro-8-oxo-guanine specificity and is crucial for mutation avoidance
23. Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion
24. Systemic hypoxia changes the organspecific distribution of vascular endothelial growth factor and its receptors
25. Erythropoietin gene expression in human, monkey and murine brain
26. Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein
27. Base excision repair in yeast and mammals
28. Hypoxia, hyperoxia, ischemia, and brain necrosis
29. Induction of oxidative DNA damage in the peri-infarct region after permanent focal cerebral ischemia
30. Cerebral metabolism in hypoxic hypoxia. I. Pattern of activation of glycolysis: A re-evaluation
31. Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression
32. Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria
33. Purification and characterization of a mammalian homolog of Escherichia coli MutY mismatch repair protein from calf liver mitochondria
34. Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair
35. Action of mitochondrial DNA polymerase gamma at sites of base loss or oxidative damage
36. SMART, a simple modular architecture research tool: Identification of signaling domains
37. Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice
38. Oxidative damage and mitochondrial decay in aging
39. Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage
40. Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage
41. Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine: 8-oxoguanine DNA glycosylase
42. Nuclear localization of the human mutY homologue hMYH
43. Detection of 8-oxoG DNA glycosylase activity and OGG1 transcripts in the rat CNS
44. Phenotypic change caused by transcriptional bypass of uracil in nondividing cells
45. Chronic phencyclidine increases NMDA receptor NR1 subunit mRNA in rat forebrain
46. Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells
47. Cytochrome oxidase: An endogenous metabolic marker for neuronal activity
48. Enhanced activity of adenine DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch
49. DNA repair enzymes in the brain. DNA polymerase beta and poly (ADP-ribose) polymerase