Mitochondrial DNA synthesis studied autoradiographically in various cell types in vivo

Brazilian Journal of Medical and Biological Research

Volumn 31, Issue 2, 1998, Pages 289-298

  Korr, H ^a   Kurz, C ^a   Seidler, T O ^a   Sommer, D ^a   Schmitz, C ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Aging; Autoradiography; Mitochondrial DNA synthesis; Turnover of mitochondria; Unscheduled DNA synthesis

Indexed keywords

ANIMALIA; RODENTIA;

MITOCHONDRIAL DNA;

AGING; ANIMAL; AUTORADIOGRAPHY; BIOSYNTHESIS; CELL AGING; MITOCHONDRION; MOUSE; PHYSIOLOGY; REVIEW;

AGING; ANIMALS; AUTORADIOGRAPHY; CELL AGING; DNA, MITOCHONDRIAL; MICE; MITOCHONDRIA;

EID: 0031990207     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X1998000200012     Document Type: Article

References (59)

1. Attardi G & Schatz R (1988). Biogenesis of mitochondria. Annual Review of Cell Biology, 4: 289-333.
2. Johns DR (1995). Mitochondrial DNA and disease. New England Journal of Medicine, 333: 638-644.
3. Nass MMK (1969). Mitochondrial DNA: advances, problems and goals. Science, 165: 25-35.
4. Neubert D, Helge H & Bass R (1965). Einbau von Thymidin in die Desoxyribonucleinsäure von Mitochondrien. Naunyn-Schmiedeberg's Archiv für Experimentelle Pathologie und Pharmakologie, 252: 258-268.
5. Lonati-Galligani M, Lohmann PHM & Berends F (1983). The validity of the autoradiographic method for detecting DNA repair synthesis in the rat hepatocytes in primary culture. Mutation Research, 113: 145-160.
6. Avola R, Serra J, Curti D, Lombarde B, Remis M, Condorelli DF & Giuffrida AM (1986). Nuclear and mitochondrial DNA synthesis and energy metabolism in primary rat glial cell cultures. Neurochemical Research, 11: 789-800.
7. 3H-thymidine incorporation into rat zona fasciculata mitochondria. Cell and Tissue Research, 151: 281-292.
8. Nussdorfer GG, Mazzocchi G, Rebuffat P, Belloni AS, Gottardo G & Gambino AM (1975). Investigations on the turnover of adrenocortical mitochondria. III. Stereologic and autoradiographic observations on the effect of chronic treatment with dexamethasone on the rat zona fasciculate mitochondria. Cell and Tissue Research, 163: 273-290.
9. 3H-thymidine injected rats. Anatomical Record, 188: 125-132.
10. Nussdorfer GG, Neri G & Mazzocchi G (1978). Investigations on the turnover of adrenocortical mitochondria. XII. Studies on the mechanism of the ACTH-induced elongation of the half-life of rat zona fasciculata mitochondria. Anatomical Record, 192: 435-440.
11. 3H-thymidine-injected rats. Cell and Tissue Research, 172: 149-156.
12. Korr H & Schultze B (1989). Unscheduled DNA synthesis in various types of cells of the mouse brain in vivo. Experimental Brain Research, 74: 573-578.
13. Korr H, Koeser KC, Oldenkott S & Schmidt H (1989). X-ray dose-effect relationship of unscheduled DNA synthesis and spontaneous unscheduled DNA synthesis in mouse brain cells studied in vivo. Radiation and Environmental Biophysics, 28: 13-26.
14. Reichard P & Estborn B (1951). Utilization of desoxyribosides in the synthesis of polynucleotides. Journal of Biological Chemistry, 188: 839-846.
15. Schultze B (1969). Autoradiography at the cellular level. In: Pollister AE (Editor), Techniques in Biological Research. Vol. III, Part B. Academic Press, New York, London.
16. Cleaver JE (1967). Thymidine metabolism and cell kinetics. In: Neuberger A & Tatum EL (Editors), Frontiers of Biology. Vol. 6. North-Holland Publication Company, Amsterdam.
17. Korr H, Kurz C & Bertram C (1989). Extent of mitochondrial DNA synthesis of different cell types in the brain of the adult mouse. Clinical Neuropathology, 8: 236 (Abstract).
18. Bryant BJ (1966). The incorporation of tritium from thymidine into proteins of the mouse. Journal of Cell Biology, 29: 29-36.
19. Commerford SL, Carsten AL & Cronkite EP (1977). The distribution of tritium in the glycogen, hemoglobin and chromatin of mice receiving tritium in their drinking water. Radiation Research, 72: 333-342.
20. Korr H & Schmidt H (1988). An improved procedure for background correction in autoradiography. Histochemistry, 88: 407-410.
21. England JM, Rogers AW & Miller RG (1973) The identification of labelled structures on autoradiographs. Nature, 242: 612-613.
22. Howard A & Pelc SR (1951). Nuclear incorporation of P-32 as demonstrated by autoradiographs. Experimental Cell Research, 2: 178-187.
23. Dolbeare F (1995), Bromodeoxyuridine: a diagnostic tool in biology and medicine. Part I: Historical perspectives, histochemical methods and cell kinetics. Histochemical Journal, 27: 339-369.
24. Korr H (1980). Proliferation of different cell types in the brain. Advances in Anatomy, Embryology and Ceil Biology, 61: 1-72.
25. Setlow RB & Carrier WL (1964). The disappearance of thymine dimers from DNA: An error-correcting mechanism. Proceedings of the National Academy of Sciences, USA, 51: 226-231.
26. Boyce RP & Howard-Flanders P (1964). Release of ultraviolet light-induced thymine dimers from DNA in E. coli K-12. Proceedings of the National Academy of Sciences, USA, 51: 293-300.
27. Rasmussen RE & Painter RB (1964). Evidence for repair of ultraviolet damaged deoxyribonucleic acid in cultured mammalian cells. Nature, 203: 1360-1362.
28. Korr H (1987). Autoradiographische Untersuchungen zum Vergleich der DNA-Syntheserate prolifenerender Zellen zur DNA-Reparatur-Syntheserate nichtproliferierender Zellen im Gehirn der adulten Maus. Verhandlungen der Anatomischen Gesellschaft, 81: 851-852.
29. Painter RB & Young BR (1972). Repair replication in mammalian cells after X-irradiation. Mutation Research, 14: 225-235.
30. Regan JD & Setlow RB (1974). Two forms of repair in the DNA of human cells damaged by chemical carcinogens and mutagens. Cancer Research, 34: 3318-3325.
31. Korr H, Bertram C, Voßen U, Schmilz C, Bunzeck S, Nacken M & Karbach F (1990). The phenomenon of aging. In: Elsner N & Roth G (Editors), Brain-Perception-Cognition. 18th Göttingen Neurobiology Conference. Thieme, Stuttgart, New York, 348 (Abstract)
32. Korr H, Philippi V, Helg C, Schiefer J, Graeber MB & Kreutzberg GW (1997) Unscheduled DNA synthesis and mitochondrial DNA synthetic rate following injury of the facial nerve Acta Neuropathologica (in press).
33. Yoshizawa K, Furuno I, Yada T & Matsudaira H (1978). Induction and repair of strand breaks and 3′-hydroxy terminals in the DNA of mouse brain following gamma irradiation. Biochimica et Biophysica Acta, 521: 144-154.
34. Gerda H, Johanson KJ & Rosander K (1979). Radiation-induced DNA Strand breaks and their repair in the developing rat brain. International Journal of Radiation Biology, 36: 65-73.
35. Cerda H & Rosander K (1983). DMA damage in irradiated endothelial cells of the rat cerebral cortex. Protective action of cysteamine in vivo, Radiation Research, 95: 317-326.
36. Wheeler KT & Wierowski JV (1983). DNA accessibility: A determinant of mammalian cell differentiation. Radiation Research, 93: 312-318.
37. Wheeler KT & Wierowski JV (1983). DNA repair kinetics in irradiated undifferentiated and terminally differentiated cells. Radiation and Environmental Biophysics, 22: 3-19.
38. Singh G, Hauswirth WW, Ross WE & Neims AH (1985) A method for assessing damage to mitochondrial DNA caused by radiation end epichlorohydrin. Molecular Pharmacology, 27: 167-170.
39. Clayton DA, Doda JN & Friedberg NC (1974). The absence of pyrimidine dimer repair mechanism in mammalian mitochondria. Proceedings of the National Academy of Sciences, USA, 71: 2777-2781.
40. Le Doux SP, Wilson GL, Beecham EZ, Steunser T, Wassermann K & Bohr VA (1992). Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells. Carcinogenesis, 13: 1967-1973.
41. Yakes FM & van Houten B (1997). Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proceedings of the National Academy of Sciences, USA, 94: 514-519.
42. Robin ED & Wong R (1988). Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells. Journal of Cellular Physiology, 136: 507-513.
43. Satoh M & Kuroiwa T (1991) Organization of multiple nucleoids and DNA molecules in mitochondria of a human cell. Experimental Cell Research, 196: 137-140.
44. Kuroiwa T, Ohta T, Kuroiwa H & Shigeyuki K (1994). Molecular and cellular mechanisms of mitochondrial nuclear division and mitochondriokinesis. Microscopical Research and Techniques, 27: 220-232.
45. Clayton DA (1982). Replication of animal mitochondrial DNA. Cell, 28: 693-705
46. Ashwell M & Work TS (1970). The biogenesis of mitochondria. Annual Review of Biochemistry, 39: 251-290.
47. 3H-Autoradiographie. Experimental Cell Research, 33: 8-18.
48. 3H-ß-self-absorption for quantitative evaluation of grain number in autoradiographic studies, Interferometric studies of different cell types in the mouse brain. Histochemistry, 83: 65-70.
49. 3H-ß-self-absorption for quantitative autoradiography of different cell types in the brain of pre- and postnatal mice. Histochemistry and Cell Biology (in press).
50. Schmílz C (1994). Spontane DNA-Reparatur-Synthese rate verschiedener Zellarten in Cortex und Hippocampus der Maus als Funktion des Lebensalters. Doctoral thesis, Medizinische Fakultät der RWTH Aachen.
51. Gross NJ, Getz GS & Rabinowitz M (1969). Apparent turnover of mítochondrial desoxyribonucleic acid and mitochondrial phospholipids in the tissue of the rat. Journal of Biological Chemistry, 244: 1552-1562.
52. Korr H (1981). Light microscopical autora-diography of nervous tissue. In: Heym C & Forssmann WG (Editors), Techniques in Neuroanatomical Research. Springer Verlag, Berlin, Heidelberg, New York, 218-244.
53. Menzies RA & Gold PH (1971). The turnover of mitochondria in a variety of tissues of young and aged rats. Journal of Biological Chemistry, 246: 2425-2429.
54. Miquel J (1991). An integrated theory of aging as the result of mitochondrial-DNA mutation in differentiated cells. Archives of Gerontology and Geriatrics, 12: 99-117.
55. Miquel J (1992). An update on the mitochondrial DNA mutation hypothesis of cell aging. Mutation Research, 275: 209-216.
56. Gensler HI & Bernstein H (1981). DNA damage as the primary cause of aging. Quarterly Review of Biology, 56: 279-303.
57. Zurcher C, van Zwieten MJ, Solleveld HA & Hollander CF (1982). Aging research. In: Forster HL (Editor), The Mouse in Biomedical Research. Vol. IV. Academic Press, New York, 11-35.
58. Bandy B & Davidson AJ (1990). Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging? Free Radical Biology and Medicine, 8: 523-539
59. Harman D (1972). The biological clock: The mitochondria? Journal of the American Geriatrics Society, 20: 145-147.