Detection of DNA base-excision repair activity for oxidative lesions in adult rat brain mitochondria

Journal of Neuroscience Research

Volumn 61, Issue 2, 2000, Pages 225-236

  Chen, Dexi ^a   Jing, Lan ^a   Pei, Wei ^a   Chen, Jun ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

Author keywords

Base excision repair; Brain; DNA damage; Mitochondria; Oxidative stress

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; APURINIC ACID; DNA; DNA POLYMERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; URACIL;

AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN MITOCHONDRION; DEGENERATIVE DISEASE; DNA ADDUCT; DNA REPAIR; EXCISION REPAIR; GENE EXPRESSION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; DNA DAMAGE; DNA LIGASES; DNA REPAIR; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; MALE; MITOCHONDRIA; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SUBCELLULAR FRACTIONS;

EID: 0343517173     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20000715)61:2<225::AID-JNR13>3.0.CO;2-0     Document Type: Article

References (52)

1. Ames BN, Shigenaga MK, Gold LS. 1993. DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis. Environ Health Perspect 101(Suppl 5):35-44.
2. Anson RM, Croteau DL, Stierum RH, Filburn C, Parsell R, Bohr VA. 1998. Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA. Nucleic Acids Res 26:662-668.
3. Bessho T, Tano K, Kasai H, Ohtsuka E, Nishimura S. 1993. Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells. J Biol Chem 268:19416-19421.
4. Bowling AC, Mutisya EM, Walker LC, Price DL, Cork LC, Beal MF. 1993. Age-dependent impairment of mitochondrial function in primate brain. J Neurochem 60:196-1967.
5. Chan PH. 1996. Role of oxidants in ischemic brain damage. Stroke 27:1124-1129.
6. Clayton DA, Doda JN, Friedberg EC. 1974. The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. Proc Natl Acad Sci USA 71:2777-2781.
7. Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, Beal MF, Wallace DC. 1992. Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nature Genet 2:324-329.
8. Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, McKee AC, Beal MF, Graham BH, Wallace DC. 1994. Marked changes in mitochondrial DNA deletion levels in Alzheimer brains. Genomics 23:471-476.
9. Cortopassi GA, Shibata D, Soong NW, Arnheim N. 1992. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci USA 89:7370-7374.
10. Croteau DL, Bohr VA. 1997. Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells. J Biol Chem 272:25409-25412.
11. Croteau DL, Ap Rhys CM, Hudson EK, Dianov GL, Hansford RG, Bohr VA. 1997. An oxidative damage-specific endonuclease from rat liver mitochondria. J Biol Chem 272:27338-27344.
12. Dianov G, Lindahl T. 1994. Reconstitution of the DNA base excision-repair pathway. Curr Biol 4:1069-1076.
13. Driggers WJ, LeDoux SP, Wilson GL. 1993. Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells. J Biol Chem 268: 22042-22045.
14. Daggers WJ, Holmquist GP, LeDoux SP, Wilson GL. 1997. Mapping frequencies of endogenous oxidative damage and the kinetic response to oxidative stress in a region of rat mtDNA. Nucleic Acids Res 25:4362-4369.
15. Floyd RA, Carney JM. 1992. Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann Neurol 32:S22-27.
16. Friedberg EC. 1985. Nucleotide excision repair of DNA in eukaryotes: comparisons between human cells and yeast. Cancer Surv 4:529-555.
17. Halliwell B. 1989. Oxidants and the central nervous system: some fundamental questions. Is oxidant damage relevant to Parkinson's disease, Alzheimer's disease, traumatic injury or stroke? Acta Neurol Scand Suppl 126:23-33.
18. Harmon HJ, Nank S, Floyd RA. 1987. Age-dependent changes in rat brain mitochondria of synaptic and non-synaptic origins. Mech Ageing Dev 38:167-177.
19. Insdorf NF, Bogenhagen DF. 1989. DNA polymerase gamma from Xenopus laevis. II. A 3′-5′ exonuclease is tightly associated with the DNA polymerase activity. J Biol Chem 264:21498-21503.
20. Lan J, Henshall DC, Simon RP, Chen J. 2000. Formation of the base modification 8-hydroxyl-2′-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat. J Neurochem 74:302-309.
21. LeDoux SP, Patton NJ, Avery LJ, Wilson GL. 1993. Repair of N-methylpurines in the mitochondrial DNA of xeroderma pigmentosum complementation group D cells. Carcinogenesis 14:913-917.
22. Levin CJ, Zimmerinan SB. 1976. A DNA ligase from mitochondria of rat liver. Biochem Biophys Res Commun 69:514-520.
23. Lindahl T, Barnes DE. 1992. Mammalian DNA ligases. Annu Rev Biochem 61:251-281.
24. Longley MJ, Prasad R, Srivastava DK, Wilson SH, Copeland WC. 1998. Identification of 5′-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro. Proc Natl Acad Sci USA 95:12244-12248.
25. McBride TJ, Schneider JE, Floyd RA, Loeb LA. 1992. Mutations induced by methylene blue plus light in single-stranded M13mp2. Proc Natl Acad Sci USA 89:6866-6870.
26. Mecocci P, MacGarvey U, Kaufman AE, Koontz D, Shoffner JM, Wallace DC, Beal MF. 1993. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol 34:609-616.
27. Mirzayans R, Enns L, Cubitt S, Karimian K, Radatus B, Paterson MC. 1994. Effect of DNA polymerase inhibitors on repair of gamma ray-induced DNA damage in proliferating (intact versus permeable) human fibroblasts: evidence tor differences in the modes of action of aphidicolin and 1-beta-D-arabinofuranosyleytosine. Biochim Biophys Acta 1227:92-100.
28. Murakami K, Kondo T, Kawase M, Li Y, Sato S, Chen SF, Chan PH. 1998. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci 18:205-213.
29. Parker WD Jr, Filley CM, Parks JK. 1990. Cytochrome oxidase deficiency in Alzheimer's disease. Neurology 40:1302-1303.
30. Pettepher CC, LeDoux SP, Bohr VA, Wilson GL. 1991. Repair of alkalilabile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin. J Biol Chem 266:3113-3117.
31. Pinz KG, Bogenhagen DF. 1998. Efficient repair of abasic sites in DNA by mitochondrial enzymes. Mol Cell Biol 18:1257-1265.
32. Pinz KG, Shibutani S, Bogenhagen DF. 1995. Action of mitochondrial DNA polymerase gamma at sites of base loss or oxidative damage. J Biol Chem 270:9202-9206.
33. Richter C. 1992. Reactive oxygen and DNA damage in mitochondria. Mutat Res 275:249-255.
34. Rosenquist TA, Zharkov DO, Grollman AP. 1997. Cloning and characterization ot a mammalian 8-oxoguanine DNA glycosylase. Proc Natl Acad Sci USA 94:7429-7434.
35. Ryoji M, Katayama H, Fusamae H, Matsuda A, Sakai F, Utano H. 1996. Repair of DNA damage in a mitochondrial lysate of Xenopus laevis oocytes. Nucleic Acids Res 24:4057-4062.
36. Satoh MS, Lindahl T. 1994. Enzymatic repair of oxidative DNA damage. Cancer Res 54:1899s-1901s.
37. 6-ethylguanine from mitochondrial DNA in rat tissues exposed to N-ethyl-N-nitrosourea in vivo. J Biol Chem 263:6854-6856.
38. Schneider JE, Price S, Maidt L, Gutteridge JM, Floyd RA. 1990. Methylene blue plus light mediates 8-hydroxy 2′-deoxyguanosine formation in DNA preferentially over strand breakage. Nucleic Acids Res 18:631-635.
39. Shoffner JM, Watts RL, Juncos JL, Torroni A, Wallace DC. 1991. Mitochondrial oxidative phosphorylation detects in Parkinson's disease [see comments]. Ann Neurol 30:332-339.
40. Singh G, Maniccia-Bozzo E. 1990. Evidence for lack of mitochondrial DNA repair following cis-dichlorodiammineplatinum treatment. Cancer Chemother Pharmacol 26:97-100.
41. Sobol RW, Horton JK, Kuhn R, Gu H, Singhal RK, Prasad R, Rajewsky K, Wilson SH. 1996. Requirement of mammalian DNA polymerase-beta in base-excision repair [published errata appear in Nature 379:848, 1996, and 383:457, 1996]. Nature 379:183-186.
42. Subba Rao K, Martin GM, Loeb LA. 1985. Fidelity of DNA polymerase-beta in neurons from young and very aged mice. J Neurochem 45:1273-1278.
43. Sun D, Gilboe DD. 1994. Ischemia-induced changes in cerebral mitochondrial free fatty acids, phospholipids, and respiration in the rat. J Neurochem 62:1921-1928.
44. Swerdlow RH, Parks JK, Miller SW, Tuttle JB, Trimmer PA, Sheehan JP, Bennett JP Jr, Davis RE, Parker WD Jr. 1996. Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol 40:663-671.
45. Taffe BG, Larminat F, Laval J, Croteau DL, Anson RM, Bohr VA. 1996. Gene-specific nuclear and mitochondrial repair of formamidopyrimidine DNA glycosylase-sensitive sites in Chinese hamster ovary cells. Mutat Res 364:183-192.
46. Tomkinson AE, Bonk RT, Linn S. 1988. Mitochondrial endonuclease activities specific for apurinic/apyrimidinic sites in DNA from mouse cells. J Biol Chem 263:12532-12537.
47. Tom AF, Kunkel TA, Englund PT. 1994. A beta-like DNA polymerase from the mitochondrion of the trypanosomatid Crithidia fasciculata. J Biol Chem 269:8165-8171.
48. Tritschler HJ, Medori R. 1993. Mitochondrial DNA alterations as a source of human disorders. Neurology 43:280-288.
49. van der Kemp PA, Thomas D, Barbey R, de Oliveira R, Boiteux S. 1996. Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methyl-formamidopyrimidine. Proc Natl Acad Sci USA 93:5197-5202.
50. Wang GJ, Nutter LM, Thayer SA. 1997. Insensitivity of cultured rat cortical neurons to mitochondrial DNA synthesis inhibitors: evidence for a slow turnover of mitochondrial DNA. Biochem Pharmacol 54:181-187.
51. Wood RD. 1989. Repair of pyrimidine dimer ultraviolet light photoproducts by human cell extracts. Biochemistry 28:8287-8292.
52. Zhang C, Baumer A, Maxwell RJ, Linnane AW, Nagley P. 1992. Multiple mitochondrial DNA deletions in an elderly human individual. FEBS Lett 297:34-38.