Nuclear localization of the human mutY homologue hMYH

Journal of Cellular Biochemistry

Volumn 77, Issue 4, 2000, Pages 666-677

  Tsai Wu, Jyy Jih ^a   Su, Ho Ting ^b   Wu, Ya Lei ^b   Hsu, Su Ming ^b   Wu, C H Herbert ^b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

AP lyase; Glycosylase; Mismatch repair; Mutator; Oxidative damage

Indexed keywords

DNA GLYCOSYLTRANSFERASE; RECOMBINANT PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; ENZYME ACTIVITY; ESCHERICHIA COLI; MAMMAL CELL; NUCLEOLUS; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

AMINO ACID SEQUENCE; BASE PAIR MISMATCH; BLOTTING, WESTERN; CARBON-OXYGEN LYASES; CELL NUCLEUS; CLONING, MOLECULAR; DEOXYRIBONUCLEASE IV (PHAGE T4-INDUCED); DNA GLYCOSYLASES; DNA REPAIR; DNA, COMPLEMENTARY; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ESCHERICHIA COLI PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE; GLYCOSYLATION; HELA CELLS; HUMANS; INCLUSION BODIES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; N-GLYCOSYL HYDROLASES; PHENOTYPE; PLASMIDS; PRECIPITIN TESTS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034038827     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(20000615)77:4<666::AID-JCB14>3.0.CO;2-X     Document Type: Article

References (45)

1. Aburatani H, Hippo Y, Ishida T, Takashima R, Matsuba C, Kodama T, Takao M, Yasui A, Yamamoto K, Asano M. 1997. Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. Cancer Res 57:2151-2156.
2. Ames BN. 1989. Endogenous oxidative DNA damage, aging, and cancer. Free Radic Res Commun 7:121-128.
3. Ames BN, Gold LS. 1991. Endogenous mutagens and the causes of aging and cancer. Mutat Res 250:3-16.
4. Boiteux S, O'Connor TR, Lederer F, Gouyette A, Laval J. 1990. Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites. J Biol Chem 265:3916-3922.
5. Cabrera M, Nghiem Y, Miller JH. 1988. mutM, a second mutator locus in Escherichia coli that generates G.C-T.A transversions. J Bacteriol 170:5405-5407.
6. Cheng KC, Cahill DS, Kasai H, Nishimura S, Loeb LA. 1992. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions. J Biol Chem 267:166-172.
7. Chetsanga CJ, Lindahl T. 1979. Release of 7-methyl-guanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichia coli. Nucleic Acids Res 6:3673-3684.
8. Feng XH, Filvaroff EH, Derynck R. 1995. Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors. J Biol Chem 270: 24237-24245.
9. Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN. 1990. Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA 87:4533-4537.
10. Gogos A, Cillo J, Clarke ND, Lu AL. 1996. Specific recognition of A/G and A/7,8-dihydro-8-oxoguanine (8-oxoG) mismatches by Escherichia coli MutY: removal of the C-terminal domain preferentially affects A/8-oxoG recognition. Biochemistry 35:16665-16671.
11. Halliwell B, Gutteridge JMC. 1999. Free radicals in biology and medicine. New York: Oxford University Press.
12. Harlow E, Lane D. 1988. Antibodies: a laboratory manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
13. Kuo CF, McRee DE, Fisher CL, O'Handley SF, Cunningham RP, Tainer JA. 1992. Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III. Science 258: 434-440.
14. Labahn J, Scharer OD, Long A, Ezaz-Nikpay K, Verdine GL, Ellenberger TE. 1996. Structural basis for the excision repair of alkylation-damaged DNA. Cell 86:321-329.
15. Lu AL, Fawcett WP. 1998. Characterization of the recombinant MutY homolog, an adenine DNA glycosylase, from yeast Schizosaccharomyces pombe. J Biol Chem 273:25098-25105.
16. Lu AL, Yuen DS, Cillo J. 1996. Catalytic mechanism and DNA substrate recognition of Escherichia coli MutY protein. J Biol Chem 271:24138-24143.
17. Lu R, Nash HM, Verdine GL. 1997. A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer. Curr Biol 7:397-407.
18. Maki H, Sekiguchi M. 1992. MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature 355:273-275.
19. Manuel RC, Lloyd RS. 1997. Cloning, overexpression, and biochemical characterization of the catalytic domain of MutY. Biochemistry 36:11140-11152.
20. McGoldrick JP, Yeh YC, Solomon M, Essigmann JM, Lu AL. 1995. Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein. Mol Cell Biol 15:989-996.
21. Michaels ML, Miller JH. 1992. The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine). J Bacteriol 174:6321-6325.
22. Michaels ML, Tchou J, Grollman AP, Miller JH. 1992. A repair system for 8-oxo-7,8-dihydrodeoxyguanine. Biochemistry 31:10964-10968.
23. Moriya M, Grollman AP. 1993. Mutations in the mutY gene of Escherichia coli enhance the frequency of targeted G:C→T:A transversions induced by a single 8-oxoguanine residue in single-stranded DNA. Mol Gen Genet 239:72-76.
24. Moriya M, Ou C, Bodepudi V, Johnson F, Takeshita M, Grollman AP. 1991, Site-specific mutagenesis using a gapped duplex vector: a study of translesion synthesis past 8-oxodeoxyguanosine in E. coli. Mutat Res 254:281-288.
25. Nghiem Y, Cabrera M, Cupples CG, Miller JH. 1988. The mutY gene: a mutator locus in Escherichia coli that generates G.C-T.A transversions. Proc Natl Acad Sci USA 85:2709-2713.
26. Porello SL, Leyes AE, David SS. 1998. Single-turnover and pre-steady-state kinetics of the reaction of the adenine glycosylase MutY with mismatch-containing DNA substrates. Biochemistry 37:14756-14764.
27. Prickett KS, Amberg DC, Hopp TP. 1989. A calcium-dependent antibody for identification and purification of recombinant proteins. Biotechniques 7:580-589.
28. Radicella JP, Clark EA, Fox MS. 1988. Some mismatch repair activities in Escherichia coli. Proc Natl Acad Sci USA 85:9674-9678.
29. Radicella JP, Dherin C, Desmaze C, Fox MS, Boiteux S. 1997. Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 94:8010-8015.
30. Roldan-Arjona T, Wei YF, Carter KC, Klungland A, Anselmino C, Wang RP, Augustus M, Lindahl T. 1997. Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase. Proc Natl Acad Sci USA 94:8016-8020.
31. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning: a laboratory manual, 2nd edition. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
32. Shibutani S, Takeshita M, Grollman AP. 1991. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349:431-434.
33. Slupska MM, Baikalov C, Luther WM, Chiang JH, Wei YF, Miller JH. 1996. Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage. J Bacteriol 178:3885-3892.
34. Tajiri T, Maki H, Sekiguchi M. 1995. Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli. Mutat Res 336:257-267.
35. Takao M, Aburatani H, Kobayashi K, Yasui A. 1998. Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage. Nucleic Acids Res 26: 2917-2922.
36. Takao M, Zhang QM, Yonei S, Yasui A. 1999. Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine:8-oxoguanine DNA glycosylase. Nucleic Acids Res 27:3638-3644.
37. Tchou J, Grollman AP. 1993. Repair of DNA containing the oxidatively-damaged base, 8-oxoguanine. Mutat Res 299:277-287.
38. Tchou J, Kasai H, Shibutani S, Chung MH, Laval J, Grollman AP, Nishimura S. 1991. 8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Proc Natl Acad Sci USA 88:4690-4694.
39. Thayer MM, Ahern H, Xing D, Cunningham RP, Tainer JA. 1995. Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure. EMBO J 14: 4108-4120.
40. Tsai-Wu JJ, Liu HF, Lu AL. 1992. Escherichia coli MutY protein has both N-glycosylase and apurinic/ apyrimidinic endonuclease activities on A.C and A.G mispairs. Proc Natl Acad Sci USA 89:8779-8783.
41. Tsai-Wu JJ, Su MJ, Fang W, Wu CH. 1999. Preparation of heteroduplex DNA containing a mismatch base pair with magnetic beads. Anal Biochem 275:127-129.
42. Wood ML, Dizdaroglu M, Gajewski E, Essigmann JM. 1990. Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry 29:7024-7032.
43. Wu CH, Tsai-Wu JJ, Huang YT, Lin CY, Lioua GG, Lee FJ. 1998. Identification and subcellular localization of a novel Cu,Zn superoxide dismutase of Mycobacterium tuberculosis. FEBS Letters 439:192-196.
44. Yamagata Y, Kato M, Odawara K, Tokuno Y, Nakashima Y, Matsushima N, Yasumura K, Tomita K, Ihara K, Fujii Y, Nakabeppu Y, Sekiguchi M, Fujii S. 1996. Three-dimensional structure of a DNA repair enzyme, 3-methyladenine DNA glycosylase II, from Escherichia coli. Cell 86:311-319.
45. Yeh YC, Chang DY, Masin J, Lu AL. 1991. Two nicking enzyme systems specific for mismatch-containing DNA in nuclear extracts from human cells. J Biol Chem 266. 6480-6484.