Induction of oxidative DNA damage in the peri-infarct region after permanent focal cerebral ischemia

Journal of Neurochemistry

Volumn 75, Issue 4, 2000, Pages 1716-1728

  Nagayama, Tetsuya ^a,b,c   Lan, Jing ^a,b,c   Henshall, David C ^a,b,c   Chen, Dexi ^a,b,c   O'Horo, Cristine ^a,b,c   Simon, Roger P ^a,b,c   Chen, Jun ^a,b,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c LEGACY RESEARCH   (United States)

Author keywords

8 Hydroxyl 2' deoxyguanosine; Apurinic apyrimidinic abasic sites; DNA fragmentation; Focal cerebral ischemia

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIOTIN; DEOXYADENOSINE TRIPHOSPHATE; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA BASE; DNA DIRECTED DNA POLYMERASE BETA; DNA FRAGMENT; DNA NUCLEOTIDYLEXOTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APURINIC SITE; APYRIMIDINIC SITE; ARTICLE; BRAIN ISCHEMIA; BRAIN REGION; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION;

ANIMALS; BLOOD FLOW VELOCITY; BRAIN; BRAIN CHEMISTRY; BRAIN INFARCTION; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; CHROMOSOME BREAKAGE; DEOXYGUANOSINE; DISEASE MODELS, ANIMAL; DNA; DNA DAMAGE; DNA FRAGMENTATION; IN SITU NICK-END LABELING; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0033822204     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751716.x     Document Type: Article

References (59)

1. Repair kinetics of abasic sites in mammalian cells selectively monitored by the aldehyde reactive probe (ARP)
2. The role of neutrophils and platelets in a rabbit model of thromboembolic stroke
3. Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway
4. Early endonuclease activation following reversible focal ischemia in the rat brain
5. Apoptosis and necrosis after reversible focal ischemia: An in situ DNA fragmentation analysis
6. Necrosis in primary cultures of cortical neurons following ischemia-like insults: Induction of DNA strand breaks as a death mediator
7. Attenuation of postischemic brain hypoperfusion and reperfusion injury by the cyclooxygenase-lipoxygenase inhibitor BW755C
8. Early detection of DNA strand breaks in the brain after transient focal ischemia: Implications for the role of DNA damage in apoptosis and neuronal cell death
9. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia
10. DNA damage and repair in central nervous system injury: National Institute of Neurological Disorders and Stroke Workshop Summary
11. Oxidative damage to the c-fos gene and reduction of its transcription after focal cerebral ischemia
12. Polymorphonuclear leukocytes and microcirculatory perfusion in acute stroke in the SHR
13. Repair of oxidative damage to DNA: Enzymology and biology
14. Chemical determination of free radical-induced damage to DNA
15. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
16. Ischemic brain injury is mediated by the activation of poly(ADP-ribose) polymerase
17. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
18. Reverse chemical mutagenesis: Identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA
19. Role of oxygen free radicals in carcinogenesis and brain ischemia
20. Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice
21. Peroxynitrite formation in focal cerebral ischemia-reperfusion in rats occurs predominantly in the peri-infarct region
22. Modification of DNA bases in mammalian chromatin by radiation-generated free radicals
23. Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat)
24. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
25. Mutagenesis by 8-oxoguanine: An enemy within
26. Effect of tirilazad mesylate given after permanent middle cerebral artery occlusion in rat
27. Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage
28. Synthesis and damage specificity of a novel probe for the detection of abasic sites in DNA
29. Cell and tissue responses to oxidative damage
30. MDL 101,002, a free radical spin trap, is efficacious in permanent and transient focal ischemia models
31. Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: Implication of the failure of the DNA repair in neuronal apoptosis
32. Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke
33. A novel, sensitive, and specific assay for abasic sites, the most commonly produced DNA lesion
34. Generation of nitric oxide and superoxide during reperfusion after focal cerebral ischemia in rats
35. Inducible DNA base-excision-repair capacity and the evolution of oxidative DNA damage in rat brain following transient cerebral ischemia
36. Formation of the base modification 8-hydroxyl-2'-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat
37. Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat
38. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats
39. Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemiarepeffusion
40. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
41. DNA damage consistent with apoptosis in transient focal ischaemic neocortex
42. Cerebral ischemia produces laddered DNA fragments distinct from cardiac ischemia and archetypal apoptosis
43. Role of neutrophils in radical production during ischemia and reperfusion of the rat brain: Effect of neutrophil depletion on extracellular ascorbyl radical formation
44. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
45. The role of specific DNA base damages in the x-ray-induced inactivation of bacteriophage PM2
46. Activation of poly(ADP-ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia
47. Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions
48. DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways
49. DNA damage and mutation in human cells exposed to nitric oxide in vitro
50. Dose-response analysis of the effect of 21-aminosteroid tirilazad mesylate (U74006F) upon neurological outcome and ischemic brain damage in permanent focal cerebral ischemia
51. Apoptosis overview emphasizing the role of oxidative stress, DNA damage, and signal-transduction pathways
52. Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat
53. Poly(ADP-ribose) polymerase, nitric oxide and cell death
54. Depurination causes mutations in SOS-induced cells
55. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
56. Post-treatment with an inhibitor of poly-(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia
57. Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain
58. Leukocytes, macrophages and secondary brain damage following cerebral ischemia
59. Hydroxyl radical formation in hyperglycemic rats during middle cerebral artery occlusion/reperfusion