Molecular pathogenesis of nasopharyngeal carcinoma

Epstein-Barr Virus Report

Volumn 9, Issue 2, 2002, Pages 43-54

  Huang, Dolly P ^a   To, Ka Fai ^a   Lo, Kwok Wai ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

LATENT MEMBRANE PROTEIN 1; PROTEIN P14; PROTEIN P16; PROTEIN P53; PROTEIN P63; RAS PROTEIN; RETINOIC ACID RECEPTOR; TELOMERASE;

CHROMOSOME 11Q; CHROMOSOME 13Q; CHROMOSOME 3; CHROMOSOME 3P; CHROMOSOME 9; CHROMOSOME 9P; CHROMOSOME ABERRATION; CHROMOSOME LOSS; CONTROLLED STUDY; CYTOGENETICS; DNA METHYLATION; EPSTEIN BARR VIRUS; GENE DELETION; GENE MAPPING; GENE MUTATION; GENETIC ANALYSIS; HETEROZYGOSITY LOSS; HIGH RISK POPULATION; HISTOPATHOLOGY; HUMAN; NASOPHARYNX CARCINOMA; NONHUMAN; PATHOGENESIS; REVIEW; TUMOR SUPPRESSOR GENE; VIRUS LATENCY;

EID: 0036307404     PISSN: 09699252     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (98)

1. Cancer Incidence in Five Continents, 1997
2. Nasopharyngeal carcinoma: An epidemiological approach to carcinogenesis
3. EBV DNA in biopsies of Burkitt tumors and anaplastic carcinomas of the nasopharynx
4. Nasopharyngeal carcinoma X. Presence of Epstein-Barr genomes in separate epithelial cells of tumours in patients from Singapore, Tunisia and Kenya
5. Presence of EBNA in nasopharyngeal carcinoma and control patient tissues related to EBV serology
6. Epstein-Barr virus
7. High frequency of chromosome 3p deletion in histologically normal nasopharyngeal epithelia from southern Chinese
8. Epstein-Barr virus-specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma
9. Follow-up studies on Epstein-Barr virus IgA/VCA antibody-positive persons in Zhangwu County, China
10. Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma
11. Quantitative and temporal correlation between circulating cell-free Epstein-Barr virus DNA and tumor recurrence in nasopharyngeal carcinoma
12. Analysis of cell-free Epstein-Barr virus associated RNA in the plasma of patients with nasopharyngeal carcinoma
13. Epstein-Barr virus DNA in serum/plasma as a tumor marker for nasopharyngeal cancer
14. Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men
15. Tumour targeted gene therapy for nasopharyngeal carcinoma
16. Multi-step evolution of lung cancer
17. Head and neck cancer
18. High resolution allelotype of microdissected primary nasopharyngeal carcinoma
19. Detection of recurrent chromosomal gains and losses in primary nasopharyngeal carcinoma by comparative genomic hybridization
20. Genome wide detection of oncogene amplifications in nasopharyngeal carcinoma by array based comparative genomic hybridization
21. Frequent c-myc and Int-2 over-representations in nasopharyngeal carcinoma
22. The detection of the c-myc and ras oncogenes in nasopharyngeal carcinoma by immunohistochemistry
23. Epstein-Barr virus-encoded latent membrane protein 1 co-expresses with epidermal growth factor receptor in nasopharyngeal carcinoma
24. A 3q+ marker chromosome in EBV-carrying nasopharyngeal carcinomas
25. Cytogenetics of undifferentiated nasopharyngeal carcinoma xenografts from southern Chinese
26. Rearrangements of chromosome arm 3q in poorly differentiated nasopharyngeal carcinoma
27. DNA methylation errors and cancer
28. DNA hypermethylation in tumorigenesis: Eigenetics joins genetics
29. Promoter hypermethylation - Can this change alone ever designate true tumor suppressor gene function?
30. The potential prognostic, predictive, and therapeutic values of DNA methylation in cancer
31. Hypermethylation of the p16 gene in nasopharyngeal carcinoma
32. High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma
33. DNA methylation and the Epstein-Barr virus
34. The role of DNA methylation in modulating Epstein-Barr virus gene expression
35. Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma
36. Correlation of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors
37. DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: Possible implications for role as tumor suppressor gene
38. Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
39. Methylation and silencing of the retinoic acid receptor b-2 gene in breast cancer
40. Cancer cell cycles
41. Inactivation of the DNA repair gene O6-methylguanine-DNA-methyltransferase by promoter hypermethylation is a common event in multiple human neoplasia
42. Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis
43. Loss of heterozygosity on the short arm of chromosome 3 in nasopharyngeal carcinoma
44. Detailed deletion mapping on the short arm of chromosome 3 in nasopharyngeal carcinomas
45. Loss of heterozygosity on chromosome 3p in nasopharyngeal carcinoma
46. Alterations on chromosome 3 in endemic and nonendemic nasopharyngeal carcinoma
47. Analysis of genetic alterations in primary nasopharyngeal carcinoma by comparative genomic hybridization Genes
48. Genome-wide allelotype analysis of sporadic primary nasopharyngeal carcinoma from southern China
49. Molecular genetic progression on nasopharyngeal carcinoma
50. Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homogenous deletions in tumor cell lines
51. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
52. High frequency of loss of heterozygosity (LOH) in chromosome 3p14.3 in nasopharyngeal carcinoma
53. The von Hippel-Lindau (VHL) disease tumor-suppressor gene is not mutated in nasopharyngeal carcinoma
54. Genetic changes in nasopharyngeal carcinoma
55. Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3
56. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3:Identification and evaluation of the resident candidate tumor suppressor genes
57. Epigenetic inactivation of a RAS association domain family protein from the lung tumor suppressor locus 3p21.3
58. Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumors
59. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression
60. Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis
61. The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1
62. Tumor suppressor function of RASSF1A in nasopharyngeal carcinoma
63. Critical role of both retinoid nuclear receptors and retinoid-X-receptors in mediating growth inhibition of ovarian cancer cells by all-trans retinoic acid
64. In vitro inhibition of head and neck cancer-cell growth by human recombinant interferon-alpha and 13-cis retinoic acid
65. AIS is an oncogene amplified in squamous cell carcinoma
66. High level expression of deltaN-p63: A mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?
67. Absence of p53 gene mutations in primary nasopharyngeal carcinomas
68. p53 mutation in human nasopharyngeal carcinomas
69. Alterations of the p53 gene in nasopharyngeal carcinoma
70. Infrequent MDM2 gene amplification and absence of gross WAF1 gene alterations in nasopharyngeal carcinoma
71. p53 over-expression and Epstein-Barr virus infection in undifferentiated and squamous cell nasopharyngeal carcinomas
72. Detection of the tumour suppressor gene p53 in nasopharyngeal carcinoma in Hong Kong Chinese
73. A region of homozygous deletion on chromosome 9p21-22 in primary nasopharyngeal carcinoma
74. p16 gene alterations in nasopharyngeal carcinoma
75. Inhibiting tumorigenic potential by restoration of p16 in nasopharyngeal carcinoma
76. A functional investigation of tumor suppressor gene activities in a nasopharyngeal carcinoma cell line HONE1 using a monochromosome transfer approach
77. Effect of p16INK4a on chemosensitivity in nasopharyngeal carcinoma cells
78. A new regulatory motif in cell-cycle control causing specific inhibition of cyclinD/CDK4
79. A cell cycle regulator potentially involved in genesis of many tumor types
80. INK4B is a potential effector of TGF-β-induced cell cycle
81. ARF promotes MDM2 degradation and stabilizes p53:ARF-INK4a locus deletion impairs both the Rb and p53 tumour suppression pathways
82. Nasopharyngeal carcinoma shows no detectable retinoblastoma susceptibility gene alterations
83. High frequencies of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients
84. Loss of heterozygosity on the long arm of chromosome 11 in nasopharyngeal carcinoma
85. Mapping of nasopharyngeal carcinoma tumor-suppressive activity to a 1.8-megabase region of chromosome band 11q13
86. TSLC1 is a tumor-suppressor gene in human non-small cell lung cancer
87. Silencing of TSLC1 gene expression by promoter hypermethylation in nasopharyngeal carcinoma
88. Two distinct regions of deletion on chromosome 13q in primary nasopharyngeal carcinoma
89. Promoter hypermethylation of the EDNRB gene in nasopharyngeal carcinoma
90. Telomerase activation in nasopharyngeal carcinomas
91. Telomerase activity is frequently found in metaplastic and malignant human nasopharyngeal tissues
92. Frequent chromosome 9p losses in histologically normal nasopharyngeal epithelia from Southern Chinese
93. Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma
94. Epstein-Barr virus persistence and virus-associated tumours
95. In vitro production of stable Epstein-Barr virus-positive epithelial cell clones which resemble the virus: Cell interaction observed in nasopharyngeal carcinoma
96. Requirement for cell-to-cell contact in Epstein-Barr virus infection of nasopharyngeal carcinoma cells and keratinocytes
97. Infection of breast epithelial cells with Epstein-Barr virus via cell-to-cell contact