Inhibiting tumorigenic potential by restoration of p16 in nasopharyngeal carcinoma

British Journal of Cancer

Volumn 81, Issue 7, 1999, Pages 1122-1126

  Wang, G L ^a   Lo, K W ^a   Tsang, K S ^a   Chung, N Y F ^a   Tsang, Y S ^a   Cheung, S T ^a   Lee, J C K ^a   Huang, D P ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Gene transfer; Nasopharyngeal carcinoma; p16; Tumour suppressor

Indexed keywords

PROTEIN P16;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CANCER CELL CULTURE; CARCINOGENICITY; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOMETRY; DNA TRANSFECTION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; NASOPHARYNX CARCINOMA; NUDE MOUSE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0032759897     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690818     Document Type: Article

References (28)

1. Castellano M, Gabrielli BG, Hussussian CJ, Dracopoli NC and Hayward NK (1997) Restoration of CDKN2A into melanoma cells induces morphologic changes and reduction in growth rate but not anchorage-idependent growth reversal. J Invest Dermatol 109: 61-68
2. ink4. Mol Cell Biol 15: 2682-2688
3. Cheng RYS, Lo KW, Huang DP and Tsao SW (1997) Loss of heterozygosity on chromosome 14 in primary nasopharyngeal carcinoma. Int J Oncol 10: 1047-1050
4. Cheng Y, Poulos NE, Lung ML, Hampton G, Ou B, Lerman MI and Stanbridge EJ (1998) Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3. Proc Natl Acad Sci USA 95: 3042-3047
5. Fueyo J, Gomez-Manzano C, Yung WKA, Clayman GL, Liu TJ, Bruner J, Levin VA and Kyritsis AP (1996) Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells. Oncogene 12: 103-110
6. Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY and Geradts J (1998) Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product. Am J Pathol 152: 865-869
7. INK4b is a potential effector of cell cycle arrest mediated by TGF-β. Nature (Lond) 371: 257-261
8. Hinds PS, Mittnacht S, Dulic V, Arnold A, Reed SI and Weinberg RA (1992) Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70: 993-1006
9. Huang DP, Ho JHC, Poon YF, Chew EC, Saw D, Liu M, Li CL, Mak LS, Lai SH and Lau EH (1980) Establishment of a cell line (NPC/HKI) from a differentiated squamous carcinomas of the nasopharynx. Int J Cancer 26: 127-132
10. Huang DP, Lo KW, Choi PHK, Ng AYT, Tsao SY, Yiu GKC and Lee JC (1991) Loss of heterozygosity on the short arm of chromosome 3 in nasopharyngeal carcinoma. Cancer Genet Cytogenet 54: 91-99
11. Huang DP, Lo KW, van Hasselt CA, Woo JK, Chot PH, Leung SF, Cheung ST, Cairns O, Sidransky D and Lee JC (1994) A region of homozygous deletion on chromosome 9p21-22 in primary nasopharyngeal carcinoma. Cancer Res 54: 4003-4006
12. Hui ABY, Lo KW, Leung SF, Choi PH, Fong Y, Lee JC and Huang DP (1996) Loss of heterozygosity on the long arm of chromosome 11 in nasopharyngeal carcinoma. Cancer Res 56: 3225-3229
13. INK4 gene mediated by an adenovirus vector. Cancer Res 55: 3250-3253
14. Kamb A, Gruis A, Weaver Feldhaus J, Liu QY, Harshman K, Tavtigian SV, Stockert E, Day III RS, Johnson BE and Skolnick MH (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science 264: 436-439
15. Kato JY, Matsushime H, Hichert SW, Ewen ME and Sherr CJ (1993) Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D dependent kinase CDK4. Gene Dev 7: 331-342
16. Li JH, Li P, Klamut H and Liu FF (1997) Cytotoxic effects of ad5CMV-p53 expression in two human nasopharyngeal carcinoma cell lines. Clin Cancer Res 3: 507-514
17. Liggett WH Jr, Sewell DA, Rocco J, Ahrendt SA, Koch W and Sidransky D (1996) p16 and p16 are potent growth suppressors of head and neck squamous carcinoma cells in vitro. Cancer Res 56: 4119-4123
18. Lo KW, Huang DP and Lau KM (1995) p16 gene alterations in nasopharyngeal carcinoma. Cancer Res 55: 2039-2043
19. Lo KW, Cheung ST, Leung SF, van Hasselt A, Tsang YS, Mak KF, Chung YF, Woo JKS, Lee JCK and Huang DP (1996) Hypermethylation of the p16 gene in nasopharyngeal carcinoma. Cancer Res 56: 2721-2725
20. Lo KW, Huang DP and Lee JCK (1997) Genetic changes in nasopharyneal carcinoma (NPC). Chinese Med J (Beijing) 110: 548-559
21. Lu QL, Elia G, Lucas S and Thoma JA (1993) Bcl-2 proto-oncogene expression in Epstein-Barr-virus-associated nasopharyngeal carcinoma. Int J Cancer 53: 29-35
22. Miyakoshi J, Kitagawa K, Yamagishi N, Ohtsu S, Day RS III and Takebe H (1997) Increased radiosensitivity of p16 gene-deleted human glioma cells after transfection with wild-type p16 gene. Jpn J Cancer Res 88: 34-38
23. Nobori T, Miura K, Wu DJ, Lois A, Takabaryashi K and Carson DA (1994) Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (Lond) 368: 753-756
24. Pagano M, Pepper R, Lukas J, Baldin V, Ansorge W, Bartek J and Draetta G (1993) Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J Cell Biol 121: 110-111
25. Porter MJ, Field JK, Leung SF, Lo D, Lee JC, Spandidos DA and van Hasselt CA (1994) The detection of the c-myc and ras oncogenes in nasopharyngeal carcinoma by immunohistochemistry. Acta Otolaryngol 114: 105-109
26. inka/CDKN2 gene in leukaemic cell lines inhibits cell proliferation. Br J Haematol 95: 291-298
27. INK4. Mol Carcinogen 16: 53-60
28. Spruck III CH, Tsai YC, Huang DP, Yang AS, Rideout III WM, Gonzalez-Zulueta M, Choi P, Lo KW, Yu MC and Jones PA (1992) Absence of p53 gene mutations in primary nasopharyngeal carcinomas. Cancer Res 52: 4787-4790