Modulation of lipid metabolism by energy status of adipocytes: Implications for insulin sensitivity

Annals of the New York Academy of Sciences

Volumn 967, Issue , 2002, Pages 88-101

  Kopecký, Jan ^a   Flachs, Pavel ^a   Bardová, Kristina ^a   Brauner, Petr ^a   Pražák, Tomáš ^a   Šponarová, Jana ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

Adipose tissue; Lipogenesis; Lipolysis; Obesity; Uncoupling protein

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; LIPID; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3; UNCOUPLING PROTEIN 5;

ADIPOCYTE; CONFERENCE PAPER; DIABETIC OBESITY; ENERGY METABOLISM; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; LIPOGENESIS; LIPOLYSIS; NONHUMAN; RESPIRATORY CHAIN; TRANSGENE;

MUS MUSCULUS;

EID: 0036299147     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04267.x     Document Type: Conference Paper

References (103)

1. Substrate fluxes in skeletal muscle and white adipose tissue and their importance in the development of obesity
2. Failure of adipocyte differentiation causes type II diabetes mellitus?
3. Life without white fat: A transgenic mouse
4. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
5. The human obesity gene map: The 2001 update
6. Obesity - A genetic disease of adipose tissue?
7. Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue
8. Combined effects of insulin treatment and adipose tissue-specific agouti expression on the development of obesity
9. 3-adrenergic receptor deficient mice promotes diet-induced obesity
10. Paternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolism
11. 3-adrenoceptor in the regulation of body composition
12. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
13. Reduction of dietary obesity in the aP2-Ucp transgenic mice: Physiology and adipose tissue distribution
14. 1-adrenergic receptor in adipose tissue are resistant to obesity
15. Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A
16. PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
17. Effect of carbohydrate intake on de novo lipogenesis in human adipose tissue
18. Comparative study of the lipogenic potential of human and rat adipose tissue
19. Enzymes related to lipogenesis in the adipose tissue of obese subject
20. Reversing adipocyte differentiation: Implications for treatment of obesity
21. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP, and AtUCP
22. Effects of obesity on fat topography: Metabolic and endocrine determinants
23. Overview - Preparation and properties of mitochondria from different sources
24. The intracellular localization of enzymes in white-adipose-tissue fat-cells and permeability properties of fat-cell mitochondria
25. The effect of 2,4-dinitrophenol on adipose-tissue metabolism
26. ATP balance and the effect of 2,4-dinitrophenol on fatty acid synthesis
27. Metabolism of pyruvate and malate by isolated fat-cell mitochondria
28. Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells
29. Carboxylation of pyruvate by isolated rat adipose tissue mitochondria
30. Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue
31. Respiratory uncoupling induces delta-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells
32. Equilibrium between metabolic pathways producing energy: A key factor in regulating lipolysis
33. The reversible inhibition by carbonyl cyanide m-chlorophenyl hydrazone of epinephrine-stimulated lipolysis in perfused isolated fat cells
34. Reduction in adipocyte ATP by lipolytic agents: Relation to intracellular free fatty acid accumulation
35. Free fatty acid and ATP levels in adipocytes during lipolysis
36. The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets
37. Decreased insulin sensitivity due to a postreceptor defect as a consequence of ATP-deficiency in fat cells
38. Reversible reduction of insulin receptor affinity by ATP depletion in rat adipocytes
39. The significance and mechanism of mitochondrial proton conductance
40. Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation
41. Uncoupling protein 2: In vivo distribution, induction upon oxidative stress, and evidence for translational regulation
42. Energy metabolism in uncoupling protein 3 gene knockout mice
43. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
44. + transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)
45. Anion carriers in fatty acid-mediated physiological uncoupling
46. AMP decreases the efficiency of skeletal-muscle mitochondria
47. Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: Contrast with the unique cold-induced mitochondrial carrier CGI-69
48. Overexpression of UCP3 in cultured human muscle lowers mitochondrial membrane potential, raises ATP/ADP ratio, and favors fatty acid versus glucose oxidation
49. Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: An hypothesis
50. Emergence of brown adipocytes in white fat in mice is under genetic control: Effects on body weight and adiposity
51. Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes
52. Beta3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs
53. Nicotine induced uncoupling protein 1 in white adipose tissue of obese mice
54. 3-adrenergic agonists, and leptin
55. Uncoupling protein gene: Quantification of expression levels in adipose tissues of obese and non-obese humans
56. Uncoupling protein-2 gene: Reduced mRNA expression in intraperitoneal adipose tissue of obese humans
57. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans
58. Decreased white fat cell thermogenesis in obese individuals
59. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
60. Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice
61. Humoral thermogenesis and its role in maintaining energy balance
62. Novel form of lipolysis induced by leptin
63. Reduction of dietary obesity in the aP2-Ucp transgenic mice: Mechanism and adipose tissue morphology
64. Prevention of diet-induced obesity in transgenic mice overexpressing skeletal muscle lipoprotein lipase
65. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
66. Brown fat is essential for cold-induced thermogenesis, but not for obesity resistance in aP2-Ucp mice
67. Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential
68. The effect of malonyl-CoA on overt and latent carnitine acyltransferase activities in rat liver and adipocyte mitochondria
69. The optimal efficiency and the economic degrees of coupling of oxidative phosphorylation
70. Leptin physiology: A second look
71. Omega-3 polyunsaturated fatty acid regulation of gene expression
72. Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation
73. Thermogenic drugs
74. Antidiabetic agent pioglitazone enhances adipocyte differentiation of 3T3-F442A cells
75. Stimulation of adipogenesis in fibroblasts by PPARgamma2, a lipid-activated transcription factor
76. Effect of thiazolidinediones on expression of UCP2 and adipocyte markers in human PAZ6 adipocytes
77. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators
78. Regulation of lipoprotein metabolism by thiazolidinediones occurs through a distinct but complementary mechanism relative to fibrates
79. Leptin-specific patterns of gene expression in white adipose tissue
80. Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes
81. Effects of fish oil-lard diet on rat plasma lipoproteins, liver FAS, and lipolytic enzymes
82. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation
83. Uncoupling protein-3 mRNA levels are increased in white adipose tissue and skeletal muscle of bezafibrate-treated rats
84. Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells
85. Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes
86. Differential regulation of mouse uncoupling proteins among brown adipose tissue, white adipose tissue, and skeletal muscle in chronic beta 3 adrenergic receptor agonist treatment
87. Increased uncoupling protein 2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acid in addition to linolenic acid
88. Regulation of acetyl coenzyme-A carboxylase gene in a transgenic animal model
89. Increased adipose expression of the uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes
90. Leptin stimulates uncoupling protein-2 mRNA expression and Krebs cycle activity and inhibits lipid synthesis in isolated rat white adipocytes
91. Regulation of hepatic delta-6 desaturase expression and its role in the polyunsaturated fatty acid inhibition of fatty acid synthase gene expression in mice
92. Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis
93. Lipolytic effect of in vivo leptin administration on adipocytes of lean and ob/ob mice, but not db/db mice
94. Selectivity of fatty acids on lipid metabolism and gene expression
95. 4-adrenoceptor
96. Angiotensinogen, angiotensin II, and adipose tissue development
97. Overexpression of human lipoprotein lipase increases hormone-sensitive lipase activity in adipose tissue of mice
98. 3-adrenergic receptor gene
99. Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity
100. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
101. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
102. Mice lacking mitochondrial uncoupling protein are cold-sensitive, but not obese