Transgenic mice overexpressing the β1-adrenergic receptor in adipose tissue are resistant to obesity

Molecular Endocrinology

Volumn 11, Issue 1, 1997, Pages 27-38

  Soloveva, Veronica ^a,b   Graves, Reed A ^c   Rasenick, Mark M ^b   Spiegelman, Bruce M ^d   Ross, Susan R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; LIPID BINDING PROTEIN; RECEPTOR SUBTYPE;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; GENE EXPRESSION; LIPID STORAGE; LIPOLYSIS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENE; TRANSGENIC MOUSE; WHITE ADIPOSE TISSUE;

ADENYLATE CYCLASE; ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ADRENERGIC BETA-AGONISTS; ANIMALS; BODY WEIGHT; CELL DIVISION; CYCLIC AMP; DIETARY FATS; DOBUTAMINE; ENERGY INTAKE; FEMALE; GENE EXPRESSION REGULATION; HUMANS; ISOPROTERENOL; LIPID METABOLISM; LIPOLYSIS; MALE; MICE; MICE, TRANSGENIC; OBESITY; ORGAN SIZE; RECEPTORS, ADRENERGIC, BETA-1; RECOMBINANT FUSION PROTEINS; TRANSGENES;

ANIMALIA; MUS MUSCULUS;

EID: 0031016659     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.11.1.27     Document Type: Article

References (42)

1. Lafontan M, Berlan M 1993 Fat cell adrenergic receptors and the control of white and brown fat cell function. J Lipid Res 34:1057-1091
2. Nahmias C, Blin N, Elalouf J-M, Mattel MG, Strosberg AD, Emorine LJ 1991 Molecular characterization of the mouse β3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J 10:3721-3727
3. Muzzin P, Revelli J-P, Kuhne F, Gocayne JD, McCombie WR, Venter JC, Giacobino J-P, Fraser CM 1991 An adipose tissue-specific β-adrenergic receptor. Molecular cloning and down-regulation in obesity. J Biol Chem 266:24053-23058
4. Granneman JG, Lahners KN, Chaudhry A 1991 Molecular cloning and expression of the rat β3-adrenergic receptor. Mol Pharmacol 40:895-899
5. Collins S, Daniel KW, Rohlfs EM, Ramkumar V, Taylor IL, Gettys TW 1994 Impaired expression and functional activity of the β3- and β1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. Mol Endocrinol 8:518-527
6. Susulic VS, Frederich RC, Lawitts J, Tozzo E, Kahn BB, Harper ME, Himms-Hagen J, Flier JS, Lowell BB 1995 Targeted disruption of the beta 3-adrenergic receptor gene. J Biol Chem 270:29483-29492
7. Bronnikov G, Houstek J, Nedergaard J 1992 β-Adrenergic, cAMP-mediated stimulation of proliferation of brown fat cells in primary culture. Mediation via β1 but not via β2 adrenoceptors. J Biol Chem 267:2006-2013
8. Holloway BR, Howe R, Rao BS, Stribling D 1992 ICI D7114: a novel selective adrenoceptor agonist of brown fat and thermogenesis. Am J Clin Nutr 55:262S-264S
9. Himms-Hagen J, Cui J, Danforth Jr E, Taatjes DJ, Lang SS, Waters BL, Claus TH 1994 Effect of CG-316,243, a thermogenic β3-agonist, on energy balance and brown and white adipose tissues in rats. Am J Physiol 267:R1371-1371R1383
10. Zhao J, Unelius L, Bengtsson T, Cannon B, Nedergaard J 1994 Co-existing β-adrenoceptor subtypes. Am J Physiol 267:C969-C971
11. Cousin B, Cinti S, Morroni M, Raimbault S, Ricquier D, Penicaud L, Casteilla L 1992 Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci 103:931-942
12. Ross SR, Graves RA, Greenstein A, Platt KA, Shyu H-L, Mellovitz B, Spiegelman BM 1990 A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo. Proc Natl Acad Sci USA 87:9590-9594
13. Ross SR, Graves RA, Spiegelman BM 1993 Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity. Genes Dev 7:1318-1324
14. Ross, SR, Choy L, Graves RA, Fox N, Solovjeva V, Klaus S, Ricquier D, Spiegelman BM 1992 Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein. Proc Natl Acad Sci USA 89:7561-7565
15. Tozzo E, Shepherd PR, Gnudi L, Kahn BB 1995 Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis. Am J Physiol 268:E956-E964
16. Pagliassoti MJ, Knobel SM, Sahrokhi KA, Manzo AM, Hill JO 1994 Time course of adaptation to a high-fat diet in obesity-prone rats. Am J Physiol 267:R659-R664
17. Dulloo AG, Miller DS 1986 The thermogenic properties of ephedrine/methylxanthine mixtures: animal studies. Am J Clin Nutr 43:388-394
18. Himms-Hagen J 1995 Role of brown adipose tissue thermogenesis in control of thermoregulatory feeding in rats: a new hypothesis that links thermostatic and glucostatic hypotheses for control of food intake. Proc Soc Exp Biol Med 208:159-169
19. Kozak UC, Kopecky J, Teisinger J, Enerback S, Boyer B, Kozak LP 1994 An upstream enhacer regulating brown-fat specific expression of the mitochondrial uncoupling protein gene. Mol Cell Biol 14:59-67
20. Liggett SB, Freedman NJ, Schwinn DA, Lefkowitz RJ 1993 Structural basis for receptor subtype-specific regulation revealed by a chimeric beta3/beta2-adrenergic receptor. Proc Natl Acad Sci USA 90:3665-3669
21. Nantel F, Bonin H, Emorine LJ, Zilberfarb V, Strosberg AD, Bouvier M, Marullo S 1993 The human beta-3 adrenergic receptor is resistant to short term agonist-promoted desensitization. Mol Pharmacol 43:548-555
22. Nantel F, Marullo S, Krief S, Strosberg AD, Bouvier M 1994 Cell-specific down-regulation of the beta 3-adrenergic receptor. J Biol Chem 269:13148-13155
23. Revelli J-P, Muzzin P, Giacobino J-P 1993 Expression of the beta 3-adrenergic receptor in human white adipose tissue. J Mol Endocrinol 10:193-197
24. Himms-Hagen J, Triandafillou J, Begin-Heick N, Ghorbani M, Kates A-L 1995 Apparent lack of β3-adrenoceptors and of insulin regulation of glucose transport in brown adipose tissue of guinea pigs. Am J Physiol 268:R98-R104
25. Lonnqvist F, Throne A, Nilsell K, Hoffstedt J, Arner P 1995 A pathogenic role of visceral fat β3-adrenoceptors in obesity. J Clin Invest 95:1109-1116
26. Walston J, Silver K, Bogardus C, Knowler WC, Celi FS, Austin S, Manning B, Strosberg AD, Stern MP, Raben N, Sorkin JK, Roth J, Shuldiner AR 1995 Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the β3-adrenergic-receptor gene. N Engl J Med 333:343-347
27. Widen E, Lehto M, Kanninen T, Walston J, Shuldiner AR, Groop LC 1995 Association of a polymorphism in the β3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. N Engl J Med 333:348-351
28. Clement K, Vaisse C, Manning BSJ, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD 1995 Genetic variation in the β3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med 333:352-354
29. Ailhaud G, Grimaldi P, Negrel R 1992 Cellular and molecular aspects of adipose tissue development. Annu Rev Nutr 12:207-233
30. Loncar D 1991 Convertible adipose tissue in mice. Cell Tissue Res 266:149-161
31. Frielle T, Collins S, Daniel KW, Caron MG, Lefkowitz RJ, Kobilka BK 1987 Cloning of the cDNA for the human β1-adrenergic receptor. Proc Natl Acad Sci USA 84:7920-7924
32. Chirgwin JM, Prxybyla AE, MacDonald RJ, Rutter WJ 1979 Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299
33. Lehrach H, Diamond D, Wozney JM, Boedtker H 1977 RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical re-examination. Biochemistry 16:4743-4751
34. Bouillaud F, Weissenbach J, Ricquier D 1986 Complete cDNA-derived amino acid sequence of rat brown fat uncoupling protein. J Biol Chem 261:1487-1490
35. Hunt CR, Ro JH, Dobson DE, Min HY, Spiegelman BM 1986 Adipocyte P2 gene: developmental expression and homology of 5′- flanking sequences among fat cell-specific genes. Proc Natl Acad Sci USA 83:3786-3790
36. Rodbell M 1964 Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J Biol Chem 239:375-380
37. Lotan S, Chin JH, Hoffman BB 1994 Impaired β-adrenergic receptor-mediated regulation of the expression in adipocytes from older rats. Am J Physiol 266:E659-E665
38. Hirsch J, Gallian E 1968 Methods for determination of adipose cell size in man and animals. J Lipid Res 9:110-110
39. Salomon Y 1979 Adenylate cyclase assay. Adv Cyclic Nuc Res 10:35-55
40. Hatta S, Marcus MM, Rasenick MM 1986 Exchange of guanine nucleotide between GTP-binding proteins that regulate neuronal adenylate cyclase. Proc Natl Acad Sci USA 83:5439-5443
41. Granneman JG, Lahners KN, Rao DD 1992 Rodent and human β3-adrenergic receptor genes contain an intron within the protein-coding block. Mol Pharmacol 42:964-970
42. van Spronsen A, Nahmias C, Krief S, Briend-Sutren M-M, Strosberg AD, Emorine LJ (1993) The promoter and intron/exon structure of the human and mouse β3-adrenergic receptor genes. Eur J Biochem 213:1117-1124