PACAP protects hippocampal neurons against apoptosis: Involvement of JNK/SAPK signaling pathway

Annals of the New York Academy of Sciences

Volumn 865, Issue , 1998, Pages 111-117

  Shioda, Seiji ^a   Ozawa, Hiroshi ^a   Dohi, Kenji ^a   Mizushima, Hidekatsu ^a   Matsumoto, Kiyoshi ^a   Nakajo, Shigeo ^c   Takaki, Atsushi ^d   Zhou, Cheng Ji ^a   Nakai, Yasumitsu ^a   Arimura, Akira ^b  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TULANE UNIVERSITY   (United States)

^c SHOWA UNIVERSITY   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; BRAIN ISCHEMIA; CELL PROTECTION; CEREBROSPINAL FLUID; CONFERENCE PAPER; CONTROLLED STUDY; HIPPOCAMPUS; NERVE CELL NECROSIS; NONHUMAN; RAT; STRESS;

ANIMALIA;

EID: 2142725149     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb11169.x     Document Type: Conference Paper

References (19)

1. Pulsinelli, W. A., J. B. Brierley & F. Plum. 1982. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11: 491-498.
2. Deshpande, J. K., B. K. Siesjo & T. Wieloch. 1987. Calcium accumulation and neuronal damage in the hippocampus following cerebral ischemia. J. Cereb. Blood Flow Metab. 7: 89-95.
3. Kirino, T. 1982. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239: 57-69.
4. Oppenheim, R. W. 1991. Cell death during development of the nervous system. Annu. Rev. Neurosci. 14: 453-501.
5. Fukunaga, R. 1997. Target proteins of MAP kinases. Transcription factors and MAP kinases. Jikkenigaku (in Japanese) 15: 1733-1738.
6. Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis & M. E. Greenberg. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331.
7. Arimura, A., A. Somogyvari-Vigh, C. Weill, R. C. Fiore, I. Tatsuno, V. Bay, & D. E. Brenneman. 1994. PACAP functions as a neurotrophic factor. Ann. N.Y. Acad. Sci. 739: 228-243.
8. Cavallaro, S., A. Copani, V. D'Agata, S. Musco, S. Petrallia, C. Ventra, F. Stivala, S. Travali & P. L. Canonoco. 1996. Pituitary adenylate cyclase activating polypeptide prevents apoptosis in cultured cerebellar granule neurons. Mol. Pharmacol. 50: 60-66.
9. Villaba, M., J. Bockaert & L. Journot. 1997. Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway. J. Neurosci. 17: 83-90.
10. Uchida, D., A. Arimura, A. Somogyvari-Vigh, S. Shioda & B. Banks. 1996. Prevention of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase activating polypeptide. Brain Res. 736: 280-286.
11. Matsuda, S., T-C. Wen, F. Morita, H. Otsuka, K. Igase, H. Yoshimura & M. Sakanaka. 1996. Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils. Neurosci. Lett. 204: 109-112.
12. Gottschall, P. E., I. Tatsuno & A. Arimura. 1994. Regulation of interleukin-6 (IL-6) secretion in primary cultured rat astrocytes: synergism of interleukin-1 (IL-1) and pituitary adenylate cyclase activating polypeptide (PACAP). Brain Res. 637:197-203.
13. Kawai, K., L. Nitecka & C. A. Ruetzler. 1992. Global ischemia associated with cardiac arrest in the rat: I. Dynamics of early neuronal damage. J. Cereb. Blood Flow Metab. 12: 238-249.
14. Fiore, R., T. H. Murphy, J. S. Sanghera, S. Pelech & J. M. Baraban. 1993. Activation of p42 mitogen-activated protein kinase by glutamate receptor stimulation in rat primary cortical cultures. J. Neurochem. 61: 1626-1633.
15. Murphy, T. H., L. A. Blatter, R. V. Bhat, R. S. Fiore, W. G. Wier & J. M. Baraban. 1994. Differential regulation of calcium/calmodulin-dependent protein kinase II and p42 MAP kinase activity by synaptic transmission. J. Neurosci. 14: 1320-1331.
16. Rosen, L. B., D. D. Ginty, M. J. Weber & M. E. Greenberg. 1994. Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of RAS. Neuron 12: 1207-1221.
17. Gottschall, P. E., I. Tatsuno & A. Arimura. 1992. Increased sensitivity of glioblastoma cells to interleukin-1 and long-term incubation with dexamethasone. Mol. Cell Neurosci. 3: 49-55.
18. Arimura, A. & S. Shioda. 1995. Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors: neuroendocrine and endocrine interaction. Front. Endocrinol. 16: 53-88.
19. Shioda, S., Y. Shuto, A. Somogyvari, G. Legradi, H. Onda, D. H. Coy, S. Nakajo & A. Arimura. 1997. Localization and gene expression of the receptor for pituitary adenylate cyclase-activating polypeptide in the rat brain. Neurosci. Res. 28: 345-354.