Neuroprotective effect of α-phenyl-N-tert-butylnitrone in gerbil hippocampus is mediated by the mitogen-activated protein kinase pathway and heat shock proteins

Neuroscience Letters

Volumn 282, Issue 1-2, 2000, Pages 41-44

  Tsuji, M ^a   Inanami, O ^a   Kuwabara, M ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Antioxidants; Heat shock proteins; Hippocampus; Ischemia; Mitogen activated protein kinases; Spin trap; Phenyl N tert butylnitrone

Indexed keywords

ANTIOXIDANT; HEAT SHOCK PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; N TERT BUTYL ALPHA PHENYLNITRONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; GERBIL; HIPPOCAMPUS; IMMUNOBLOTTING; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPIN TRAPPING;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GERBILLINAE; HEAT-SHOCK PROTEINS; HIPPOCAMPUS; HSP70 HEAT-SHOCK PROTEINS; IMMUNOBLOTTING; ISCHEMIC ATTACK, TRANSIENT; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM PROTEINS; NEUROPROTECTIVE AGENTS; NITROGEN OXIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES;

EID: 0034678021     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)00844-2     Document Type: Article

References (17)

1. Chen J., Graham S.H., Zhu R.L., Simon R.P. Stress proteins and tolerance to focal cerebral ischemia. J. Cereb. Blood Flow Metab. 16:1996;566-577.
2. Clough-Helfman C., Phillis J.W. The free radical trapping agent N-tert-butyl-α-phenylnitrone (PBN) attenuates cerebral ischaemic injury in gerbils. Free Radic. Res. Commun. 15:1991;177-186.
3. Hall E.D., Pazara K.E., Braughler J.M. 21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils. Stroke. 19:1988;997-1002.
4. Hara H., Kato H., Kogure K. Protective effect of α-tocopherol on ischemic neuronal damage in the gerbil hippocampus. Brain Res. 510:1990;335-338.
5. Herdegen T., Claret F.X., Kallunki T., Martin-Villalba A., Winter C., Hunter T., Karin M. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J. Neurosci. 18:1998;5124-5135.
6. 2 in vitro. Brain Res. 671:1995;181-186.
7. Inanami O., Watanabe Y., Syuto B., Nakano M., Tsuji M., Kuwabara M. Oral administration of (-)catechin protects against ischemia-reperfusion-induced neuronal death in the gerbil. Free Radic. Res. 29:1998;359-365.
8. Kato H., Liu Y., Kogure K., Kato K. Induction of 27-kDa heat shock protein following cerebral ischemia in a rat model of ischemic tolerance. Brain Res. 634:1994;235-244.
9. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239:1982;57-69.
10. Lahtinen H., Koistinaho J., Kauppinen R., Haapalinna A., Keinanen R., Sivenius J. Selegiline treatment after transient global ischemia in gerbils enhances the survival of CA1 pyramidal cells in the hippocampus. Brain Res. 757:1997;260-267.
11. Ozawa H., Shioda S., Dohi K., Matsumoto H., Mizushima H., Zhou C., Funahashi H., Nakai Y., Nakajo S., Matsumoto K. Delayed neuronal cell death in the rat hippocampus is mediated by the mitogen-activated protein kinase signal transduction pathway. Neurosci. Lett. 262:1999;57-60.
12. Plumier J.C.L., Krueger A.M., Currie R.W., Kontoyiannis D., Kollias G., Pagoulatos G.N. Transgenic mice expressing the human inducible HSP70 have hippocampal neurons resistant to ischemic injury. Cell Stress Chaperones. 2:1997;162-167.
13. Shioda S., Ozawa H., Dohi K., Mizushima H., Matsumoto K., Nakajo S., Takaki A., Zhou C.J., Nakai Y., Arimura A. PACAP protects hippocampal neurons against apoptosis: involvement of JNK/SAPK signaling pathway. Ann. N.Y. Acad. Sci. 865:1998;111-117.
14. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
15. Yamashita T., Ohshima H., Asanuma T., Inukai N., Miyoshi I., Kasai N., Kon Y., Watanabe T., Sato F., Kuwabara M. The effects of α-phenyl-tert-butyl nitrone (PBN) on copper-induced rat fulminant hepatitis with jaundice. Free Radic. Biol. Med. 21:1996;755-761.
16. Yue T.L., Gu J.L., Lysko P.G., Cheng H.Y., Barone F.C., Feuerstein G. Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons. Brain Res. 574:1992;193-197.
17. Zhang Y., Zhou L., Miller C.A. A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system. Proc. Natl. Acad. Sci. USA. 95:1998;2586-2591.