Oxidative stress, plant-derived antioxidants and liver fibrosis

Planta Medica

Volumn 68, Issue 4, 2002, Pages 289-296

  Gebhardt, Rolf ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Antioxidants; Fibrogenesis; Flavonoids; Hepatic stellate cells; Reactive oxygen species

Indexed keywords

ALPHA TOCOPHEROL; ANTIFIBROTIC AGENT; ANTIOXIDANT; ASCORBIC ACID; FLAVONOID; POLYPHENOL DERIVATIVE; SILIBININ; SILICRISTIN; SILIDIANIN; SILYMARIN; XIAO CHAI HU TANG;

ANTIOXIDANT ACTIVITY; DRUG BIOAVAILABILITY; FIBROGENESIS; KUPFFER CELL; LIVER CELL; LIVER FIBROSIS; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYTOCHEMISTRY; REVIEW; STELLATE CELL;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; CYTOKINES; HEPATOCYTES; HUMANS; KUPFFER CELLS; LIVER CIRRHOSIS; OXIDATIVE STRESS; PLANT EXTRACTS; PLANTS; REACTIVE OXYGEN SPECIES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 0036257518     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-26761     Document Type: Review

References (139)

1. Hepatic fibrosis as wound repair: A progress report
2. Endless healing: TGF-β, SMADs, and fibrosis
3. Liver fibrogenensis and the role of hepatic stellate cells: New insights and prospects for therapy
4. Cellular communications and cell-matrix interactions in the pathogenesis of fibroproliferative disease: Liver fibrosis as a paradigm
5. Pathogenesis of liver fibrosis
6. Therapeutic strategies for hepatic fibrosis
7. Inhibition of hepatic fibrogenesis: A review of pharmacologic candidates
8. Current approaches to the therapy of fibrotic diseases
9. Apoptosis and liver fibrosis: Antifibrotic strategies
10. Prevention and teatment of liver fibrosis based on pathogenesis
11. Aetilogy and pathogenesis of liver cirrhosis-chemicals
12. Iron, oxidative stress and liver fibrosis
13. Iron, oxidative stress and liver fibrosis
14. Vitamin E dietary supplementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis
15. Pathogenesis of liver fibrosis: Role of oxidative stress
16. Reactive oxygen species-induced molecular damage and its application in pathology
17. Transdifferentiation of hepatic stellate (Ito cells) to myofibroblasts: A key event in hepatic fibrogenesis
18. Identification and partial characterization of a hepatocyte-derived factor promoting proliferation of cultured fat storing cells (parasinusoidal lipocytes)
19. Cytokines and the liver
20. Transforming growth factor beta (TGF-beta): A key role in liver fibrosis
21. The role of TGFbeta1 in initiating hepatic stellate cell acitivation in vivo
22. The hepatic perisinusoidal stellate cell
23. Cytokine regulation of hepatic stellate cells in liver fibrosis
24. Leukocytes as modulators of stellate cell activation
25. Lipocyte activation and hepatic fibrosis
26. Regulation of extracellular matrix synthesis by transforming growth factor β1 inhuman fat-storing cells
27. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblast-like cells - A potential mechanism of self perpetuation in liver fibrogenesis
28. Differential expression of monocyte chemotatic protein-1 (MCP-1) in transforming rat hepatic stellate cells
29. Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo
30. Human and rat hepatic stellate cells produce stem cell factor: A possible mechanism for mast cell recruitment in liver fibrosis
31. Cokulturen in der in vitro Toxikologie
32. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
33. New insights into the mechanisms of interferon alpha
34. CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair
35. Live or death: The fate of the hapatic stellate cell following hepatic injury
36. The up-and-down of hepatic stellate cells in tissue injury: Apoptosis restores cellular homeostasis
37. Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation
38. Expression of the peripheral-type bezodiazepine receptor and apoptosis induction in hepatic stellate cells
39. The fibronectin-derived antiadhesive peptides suppress the myofibroblast conversion of rat hepatic stellate cells
40. Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury
41. Activation of hepatic stellate cells by TGF-alpha and collagen type l is mediated by oxidative stress through c-myb expression
42. Inhibition of integrin signaling with ARG-Gly-Asp motifs in rat hepatic stellate cells
43. Induction of cellular processes containing collagenase and retinoid by integrin-binding to interstitial collagen in hepatic stellate cell culture
44. Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts
45. Perivenular fibrosis in alcoholic liver injury: Ultrastructure and histologic progression
46. Stellate cell activation in alcoholic fibrosis - An overview
47. Hydroxyethyl radicals in ethanol hepatoxicity
48. CYP2E1-dependent toxicity and up-regulation of antioxidant genes
49. Pathogenesis of alcoholic liver disease: Newer mechanisms of injury
50. Wine: Risk factors for liver disease and antifibrotic compounds
51. Hepatic stellate cell activation and liver fibrosis are associated with necroinflammatory injury and Th1-like response in chronic hepatitis C
52. Quantitative analysis of liver fibrosis and stellate cell changes in patients with chronic hepatitis C after interferon therapy
53. A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C
54. Metabolic zonation of the liver: Regulation and implications for liver function
55. Protective mechanisms against reactive oxygen species
56. Biology of disease. Lipid peroxidation and cellular damage in toxic liver injury
57. Regulation of gene expression by reactive oxygen
58. Mitochondrial damage induced by conditions of oxidative stress
59. 4-induced cirrhosis: Protective role of adenosine administration
60. 4-Hydroxy-2,3-alkenals as molecular mediators of oxidative stress in the pathogenesis of liver fibrosis
61. Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload
62. Acetaldehyde increases procollagen type 1 and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanisms
63. Acetaldehyde induces c-los and c-jun proto-onogenesis in fat-storing cell cultures through protein kinase c activation
64. Acetaldehyde-modified epitopes in liver biopsy specimens of alcoholic and nonalcoholic patients: Localization and association with progression of liver fibrosis
65. Intracellular signaling pathways involved in acetaldehyde-induced collagen and fibronectin gene expression in human hepatic stellate cells
66. Acetaldehyde stimulates collagen and non-collagen protein production by human fibroblasts
67. Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: Role of nitric oxide
68. Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells
69. Fibrogenic effect of oxidative stress on rat hepatic stellate cells
70. Intracellular signaling pathways in stellate cell activation
71. Gene regulation in hepatic stellate cell
72. Regulation of monocyte chemoattractant protein 1 by cytokines and oxygen free radicals in rat hepatic fat storing cells
73. Hydrogen peroxide is a novel inducer of connective tissue growth factor
74. + exchanger modulates the fibrogenic effect of oxidative stress in rat hepatic stellate cells
75. + exchange activity in human hepatic stellate cells: Effect of platelet-derived growth factor, insulin-like growth factor 1 and insulin
76. + exchanger reduces rat hepatic stellate cell activity and liver fibrosis: An in vitro and in vivo study
77. Pentoxifylline blocks hepatic stellate cells activation independently of phosphodiesterase inhibitory activity
78. NF-kappa B, lipososomes and pathogenesis of hepatic injury and fibrosis
79. Oxidative stress effect on the activation of hepatic stellate cells
80. Is NF-kappaB the sensor of oxidative stress?
81. Nuclear factor kB in proliferation, activation and apoptosis in rat hepatic stellate cells
82. WAFI systems are involved in spontaneous apoptosis and in the anti-apoptotic effect of TGF-β or TNF-alpha on activated hepatic stellate cells
83. Selective inhibition of NF-κB activation by the flavonoid hepatoprotector silymarin in HepG2. Evidence of different activating pathways
84. NF-κB to the rescue. RELs, apoptosis and cellular transformation
85. The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor betal expression in the macrophage lineage: A link between oxidative injury and fibrosclerosis
86. Characterization of 4-hydroxy-2-nonenal metabolism in stellate cell lines d from normal and cirrhotic rat liver
87. Activation of rat heaptic stellate cells leads to loss of glutathione S-transfer and their enzymatic activity against products of oxidative stress
88. Glutathione regulation in rat hepatic stellate cells. Comparative studies in primary culture and in liver injury in vivo
89. Spatial and temporal dynamics of hepatic stellate cell acitivation during oxidant-stress-induced fibrogenesis
90. Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis
91. Progression of hepatic stellate cell activation is associated with the level of oxidative stress rather than cytokines during CC14-induced fibrogenesis
92. Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells
93. Fibrosis of liver, pancreas and intestine: Common mechanisms and clear targets?
94. Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis
95. Randomized controlled trial of silymarin-treatment in patients with cirrhosis of the liver
96. Silymarin bei Hepatopathien. Fibrose-Hemmung unter Praxisbedingungen
97. Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats
98. Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen alpha 1(1) and TIMP-1
99. Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver
100. Antioxidant activity of silybin in vivo during chronic iron overload in rats
101. Antifibrotic effect of Stephania tetrandra on experimental liver fibrosis induced by bile duct ligation and scission in rats
102. Antifibrotic effects of the methanol extract of Polygonum aviculare in bibrotic rats induced by bile duct ligation and scission
103. The flavonoid quercetin ameliorates liver damage in rats with biliary obstruction
104. Herbal medicine Sho-saiko-to (TJ-9) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet
105. Effects of Sho-saiko-to, a Jananese herbal medicine, on hepatic fibrosis in rats
106. Effects of Sho-saiko-to extract on liver fibrosis in relation to the changes in hydroxyproline and retinoid levels of the liver in rats
107. A multicenter randomized controlled clinical trial of Sho-saiko-to in chronic active hepatitis
108. Sho-siako-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma
109. Polyenylphosphatidyl-choline decreases alcohol-induced oxidative stress in the baboon
110. The role of antioxidant vitamins (C and E), selenium and Nigella sativa in the prevention of liver fibrosis and cirrhosis in rabbits: New hopes
111. Hepatoprotective activity of Emblica officinalis and Chyavanaprash
112. The ethanol-soluble part of a hot-water extract from Artemisia iwayomogi inhibits liver fibrosis induced by carbon tetrachloride in rats
113. 4)
114. Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells
115. Plant polyphenols: Free radical scavengers or chain-breaking antioxidants
116. Protective role of dietary polyphenols in oxidative stress
117. Antioxidative and protective properties of extracts from leaves of the artischoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes
118. Effects of silibinin and of a synthetic analogue on isolated rat hepatic stellate cells and myofibroblast
119. Deactivation of cultured human liver myofibroblasts by trans-resveratrol, a grapevine-derived polyphenol
120. Inhibitory effects of the herbal medicine Shosaiko-to (TJ-9) on cell proliferation and procollagen gene expressions in cultured rat hepatic stellate cells
121. Apigenin decreases expression of the myofibroblast phenotype
122. Genistein, a specific inhibitor of tyrosine-specific protein kinases
123. Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships
124. Inhibition of rat liver cyclic AMP-dependent protein kinase by flavonoids
125. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY29002, quercetin, myricetin, and staurosporine
126. Inhibition of cholesterol biosynthesis in primary cultured rat hepatocytes by artichoke (Cynara scolymus L.) extracts
127. The effect of quercetin on cell cycle progression and growth of human gastric cancer cells
128. Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogens
129. Strong antiproliferative effects of baicalein in cultured rat hepatic stellate cells
130. Stress-activated protein kinases in the activation of rat hepatic stellate cells in culture
131. Quercetin inhibits Shc- and phosphatidylinositol 3-kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells
132. Comparative pharmacokinetics of silipide and silymarin in rats
133. Pharmacokinetics of silybin following oral administration of silipide in patients with extrahepatic biliary obstruction
134. The solubility and bioequivalence of silymarin preparations
135. Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients
136. Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form
137. Characteristics of delayed excretion of flavonoids in human urine after administration of Sho-saiko-to, a herbal medicine
138. Comparison of antioxidative capacities and inhibitory effects on cholesterol biosynthesis of quercetin and potential metabolites
139. The pathophysiology of lymphedema and the action of benzopyrones in reducing it