The fibronectin-derived antiadhesive peptides suppress the myofibroblastic conversion of rat hepatic stellate cells

Experimental Cell Research

Volumn 265, Issue 1, 2001, Pages 54-63

  Kato, Rina ^a   Kamiya, Sadahiro ^a   Ueki, Masaaki ^a   Yajima, Hirofumi ^a   Ishii, Tadahiro ^a   Nakamura, Hiroshi ^a   Katayama, Takashi ^a   Fukai, Fumio ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Antiadhesive factor; ED A; Fibronectin; Fibronectin fragment; Hepatic stellate cells; Integrin; Liver fibrosis; Matrix assembly; Myofibroblast; smooth muscle actin

Indexed keywords

ALPHA ACTIN; FIBRONECTIN; RETINOL;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; EXTRACELLULAR MATRIX; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; STELLATE CELL;

EID: 0035870128     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5179     Document Type: Article

References (42)

1. Fat-storing (Ito) cell biology
2. Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture
3. Sequential increases in the intrahepatic expression of epidermal growth factor, basic fibroblast growth factor, and transforming growth factor β in a bile duct ligated rat model of cirrhosis
4. Induction of β-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture
5. Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells
6. Expression of variant fibronectins in wound healing: Cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis
7. Transforming growth factor-β initiates wound repair in rat liver through induction of the EIIIA-fibronectin splice isoform
8. The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-β1
9. Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat
10. Macrophages and fibroblasts express embryonic fibronectins during cutaneous wound healing
11. Coordinate oncodevelopmental modulation of alternative splicing of fibronectin pre-messenger RNA at ED-A, ED-B, and CS1 regions in human liver tumors
12. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
13. Induction of cell migration by matrix metalloproteinase-2 cleavage of laminin-5
14. Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes
15. An amino-terminal fibronectin fragment stimulates the differentiation of ST-13 preadipocytes
16. Fibronectin degradation products containing the cytoadhesive tetrapeptide stimulate human neutrophil degranulation
17. Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression
18. Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in culture
19. Rat plasma fibronectin contains two distinct chemotactic domains for fibroblastic cells
20. Release of biological activities from quiescent fibronectin by a conformational change and limited proteolysis by matrix metalloproteinases
21. Fibronectin harbors anti-cell adhesive activity
22. Identification of the anti-adhesive site buried within the heparin-binding domain of fibronectin
23. Interaction with heparin and matrix metalloproteinase 2 cleavage expose a cryptic anti-adhesive site of fibronectin
24. The fibronectin-derived anti-adhesive peptide III14-2 suppresses adhesion and apoptosis of leukemic cell lines through down-regulation of protein-tyrosine phosphorylation
25. Modulation of apoptotic cell death by extracellular matrix proteins and a fibronectin-derived antiadhesive peptide
26. Rapid methods for isolation of human plasma fibronectin
27. Three-dimensional structure of extracellular matrix reversibly regulates morphology, proliferation and collagen metabolism of perisinusoidal stellate cells (vitamin A-storing cells)
28. Extracellular matrix regulates and L-ascorbic acid 2-phosphate further modulates morphology, proliferation, and collagen synthesis of perisinusoidal stellate cells
29. Isolation and cultivation of rat liver stellate cells
30. Adhesion activity in fibronectin's alternatively spliced domain EDa (EIIIA): Complementarity to plasma fibronectin functions
31. Mechanisms of myofibroblast activity and phenotypic modulation
32. Modulation of cell-adhesive activity of fibronectin by the alternatively spliced EDA segment
33. Soluble Arg-Gly-Asp peptides reduce collagen accumulation in cultured rat hepatic stellate cells
34. Inhibition of integrin signaling with Arg-Gly-Asp motifs in rat hepatic stellate cells
35. Focal adhesion kinase and phospholipase Cγ involvement in adhesion and migration of human hepatic stellate cells
36. Extracellular matrix assembly
37. Assembly of extracellular matrix
38. Matrix assembly of recombinant fibronectin polypeptide consisting of amino-terminal 70 kDa and carboxy-terminal 37 kDa regions
39. A fibronectin self-assembly site involved in fibronectin matrix assembly: Reconstruction in a synthetic peptide
40. Increased expression of matrix metalloproteinase-II in experimental liver fibrosis in rats
41. Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis