Intracellular signaling pathways in stellate cell activation

Alcoholism: Clinical and Experimental Research

Volumn 23, Issue 5, 1999, Pages 922-925

  Britton, Robert S ^a,b   Bacon, Bruce R ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b S LOUIS UNIV HLTH SCIENCES CENTER   (United States)

Author keywords

Alcohol; Focal Adhesion Kinase; Hepatic Stellate Cell; Mitogen Activated Protein Kinase; Protein Kinase C

Indexed keywords

ALCOHOL; CYTOKINE; FIBRONECTIN; FOCAL ADHESION KINASE; GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE C; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOL LIVER DISEASE; ANIMAL CELL; CELL ACTIVATION; CELL PROLIFERATION; CONFERENCE PAPER; EXTRACELLULAR MATRIX; FIBROGENESIS; LIVER FIBROSIS; MYOFIBROBLAST; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STELLATE CELL;

ANIMALIA;

EID: 0033028458     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1999.tb04204.x     Document Type: Conference Paper

References (30)

1. Friedman SL (1993) The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 328:1828-1835.
2. Gressner AM (1995) Cytokines and cellular crosstalk involved in the activation of fat-storing cells. J Hepatol 22:28-36.
3. Finkel T (1998) Oxygen radicals and signaling. Curr Opin Cell Biol 19:248-253.
4. Marais R, Marshall CJ (1996) Control of the ERK MAP kinase cascade by Ras and Raf. Cancer Surv 27:101-125.
5. mapk are required for fibroblast proliferation. Proc Natl Acad Sci USA 90:8319-8323.
6. Ip YT, Davis RJ (1998) Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Curr Opin Cell Biol 10:205-219.
7. Wong L, Yamasaki G, Johnson RJ, Friedman SL (1994) Induction of β-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture. J Clin Invest 94:1563-1569.
8. Davis BH, Coll D, Beno DWA (1993) Retinoic acid suppresses the response to platelet-derived growth factor in human hepatic Ito-cell-like myofibroblasts: A post-receptor mechanism independent of raf/fos/jun/ egr. Biochem J 294:785-791.
9. Marra F, Pinzani M, DeFranco R, Laffi G, Gentilini P (1995) Involvement of phosphatidylinositol 3-kinase in the activation of extracellular signal-regulated kinase by PDGF in hepatic stellate cells. FEBS Lett 376:141-145.
10. Marra F, Gentilini A, Pinzani M, Choudhury GG, Parola M, Herbst H, Dianzani MU, Laffi G, Abboud HE, Gentilini P (1997) Phosphatidyl-inositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells. Gastroenterology 112:1297-1306.
11. Downward J (1998) Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 10:262-267.
12. Poulos JE, Weber JD, Bellezzo JM, Di Bisceglie AM, Britton RS, Bacon BR, Baldassare JJ (1997) Fibronectin and cytokines increase JNK, ERK, AP-1 activity, and transin gene expression in rat hepatic stellate cells. Am J Physiol 273:G804-G811.
13. Poulos JE, Weber JD, Neuschwander-Tetri BA, Wells LD, Petersen PF, Baldassare JJ, Britton RS, Bacon BR (1997) Activation of AP-1 dependent gene expression by RGD in hepatic stellate cells is dependent on Ras, and is suppressed by N-acetylcysteine. Hepatology 26:184A.
14. Jarnagin WR, Rockey DC, Koteliansky VB, Wang SS, Bissell DM (1994) Expression of variant fibronectins in wound healing: Cellular sources and biological activity of the EIIIA segment in rat hepatic fibrogenesis. J Cell Biol 127:2037-2048.
15. Schaller MD, Parsons JT (1993) Focal adhesion kinase: An integrin-linked protein tyrosine kinase. Trends Cell Biol 3:258-262.
16. Howe A, Aplin AE, Alahari SK, Juliano RL (1998) Integrin signaling and cell growth control. Curr Opin Cell Biol 10:220-231.
17. Plopper GE, McNamee HP, Dike LE, Bojanowski K, Ingber DE (1995) Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol Biol Cell 6:1349-1365.
18. Carloni V, Romanelli RG, Pinzani M, Laffi G, Gentilini P (1996) Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells. Gastroenterology 110:1127-1136.
19. Racine-Samson L, Rockey DC, Bissell DM (1997) The role of α1β1 integrin in wound contraction. A quantitative analysis of liver myofibroblasts in vivo and in primary culture. J Biol Chem 272:30911-30917.
20. Carloni V, Romanelli RG, Pinzani M, Laffi G, Gentilini P (1997) Focal adhesion kinase and phospholipase Cγ involvement in adhesion and migration of human hepatic stellate cells. Gastroenterology 112:522-531.
21. Nishizuka Y (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-614.
22. Berridge MJ (1984) Inositol triphosphate and diacylglycerol as second messengers. Biochem J 220:345-360.
23. Blackshear PJ (1993) The MARCKS family of cellular protein kinase C substrates. J Biol Chem 268:1501-1504.
24. Kobayashi Y, Britton RS, O'Neill R, Bacon BR (1993) Regulation of protein kinase C isoforms in rat hepatic lipocytes. Gastroenterology 104:A929.
25. Borner C, Guadagno SN, Fabbro D, Weinstein IB (1992) Expression of four protein kinase C isoforms in rat fibroblasts: Distinct subcellular distribution and regulation by calcium and phorbol esters. J Biol Chem 267:12892-12899.
26. Huwiler A, Fabbro D, Stabel S, Pfeilschifter JP (1992) Immunocharacterization of delta and zeta isozymes of protein kinase C in rat renal mesangial cells. FEBS Lett 300:259-262.
27. Ramm GA, Britton RS, O'Neill R, Li L, Kohn HD, Bacon BR (1994) The role of protein kinase C in lipocyte activation in vitro. Hepatology 20:287A.
28. Britton RS, O'Neill R, Brady LM, Fox ES, Bacon BR (1996) Platelet-derived growth factor activates extracellular signal-regulated kinase (ERK) independently of protein kinase C in rat hepatic stellate cells. Hepatology 24:456A.
29. Casini A, Galli G, Salzano R, Ceni E, Franceschelli F, Rotella CM, Surrenti C (1994) Acetaldehyde induces c-fos and c-jun proto-oncogenes in fat-storing cell cultures through protein kinase C activation. Alcohol Alcohol 29:303-314.
30. Li JJ, O'Neill R, Chen S, Bora PS, Britton RS, Bacon BR (1998) The ethanol metabolites, fatty acid ethyl esters, activate rat hepatic stellate cells. Gastroenterology 114:A1289.