Pathogenesis of alcoholic liver disease: Newer mechanisms of injury

Keio Journal of Medicine

Volumn 48, Issue 4, 1999, Pages 184-188

  Crabb, David W ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

Alcohol metabolism; Alcoholic liver disease; Hepatic stellate cells; Kupffer cells; Oxidative stress

Indexed keywords

ENDOTOXIN;

ALCOHOL LIVER DISEASE; ALCOHOLIC FATTY LIVER; DRUG EFFECT; FEMALE; GENETICS; HUMAN; KUPFFER CELL; MALE; OXIDATIVE STRESS; REVIEW; SEXUAL DEVELOPMENT;

ENDOTOXINS; FATTY LIVER, ALCOHOLIC; FEMALE; HUMANS; KUPFFER CELLS; LIVER DISEASES, ALCOHOLIC; MALE; OXIDATIVE STRESS; SEX CHARACTERISTICS;

EID: 0033253161     PISSN: 00229717     EISSN: None     Source Type: Journal    
DOI: 10.2302/kjm.48.184     Document Type: Article

References (31)

1. Thomasson HR, Edenberg HJ, Crabb DW, Mai XL, Jerome RE, Li TK, Wang SP, Lin YT, Lu RB, Yin SJ: Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 1991; 48: 677-681
2. Tanaka F, Shiratori Y, Yokosuka O, Imazeki F, Tsukada Y, Omata M: Polymorphism of alcohol-metabolizing genes affects drinking behavior and alcoholic liver disease in Japanese men. Alcohol Clin Exp Res 1997; 21: 596-601
3. Harada S, Agarwal DP, Goedde HW, Tagaki S, Ishikawa B: Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan. Lancet 1982; 2: 827
4. Neumark YD, Friedlander Y, Thomasson HR, Li TK: Association of the ADH2*2 allele with reduced ethanol consumption in Jewish men in Israel: a pilot study. J Stud Alcohol 1998; 59: 133-139
5. Edenberg HJ, Jerome RE, Li M: Polymorphism of the human alcohol dehydrogenase 4 (ADH4) promoter affects gene expression. Pharmacogenetics 1999; 9: 25-30
6. Harada S, Okubo T, Nakamura T, Fujii C, Nomura F, Higuchi S, Tsutsumi M: A novel polymorphism (-357G/A) of the ALDH2 gene: linkage disequilibrium and an association with alcoholism. Alcohol Clin Exp Res 1999; 23: 958-962
7. Chou WY, Stewart MJ, Carr LG, Zheng D, Stewart TR, Williams A, Pinaire J, Crabb DW: An A/G polymorphism in the promoter of mitochondrial aldehyde dehydrogenase (ALDH2): effects of the sequence variant on transcription factor binding and promoter strength. Alcohol Clin Exp Res 1999; 23: 963-968
8. Goate AM, Edenberg HJ: The genetics of alcoholism. Curr Opin Genet Dev 1998; 8: 282-286
9. Hrubec Z, Omenn GS: Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcohol Clin Exp Res 1981; 5: 207-215
10. Reed T, Page WF, Viken RJ, Christian JC: Genetic predisposition to organ-specific endpoints of alcoholism. Alcohol Clin Exp Res 1996; 20: 1528-1533
11. Galli A, Price D, Crabb D: High-level expression of rat class I alcohol dehydrogenase is sufficient for ethanol-induced fat accumulation in transduced HeLa cells. Hepatology 1999; 29: 1164-1170
12. Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Willson TM, Lenhard JM, Lehmann JM: Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc Natl Acad Sci USA 1997; 94: 4318-4323
13. Bocos C. Gottlicher M, Gearing K, Banner C, Enmark E, Teboul M, Crickmore A, Gustafsson JA: Fatty acid activation of peroxisome proliferator-activated receptor (PPAR). J Steroid Biochem Mol Biol 1995; 53: 467-473
14. Panchenko LF, Pirozhkov SV, Popova SV, Antonenkov VD: Effect of chronic ethanol treatment on peroxisomal acyl-CoA oxidase activity and lipid peroxidation in rat liver and heart. Experientia 1987; 43: 580-581
15. Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ: Targeted disruption of the alpha isoform of the peroxisome proliferator activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 1995; 15: 3012-3022
16. Fan CY, Pan J, Chu R, Lee D, Kluckman KD, Usuda N, Singh I, Yeldandi AV, Rao MS, Maeda N, Reddy JK: Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J Biol Chem 1996; 271: 24698-24710
17. Wan YJ, Morimoto M, Thurman RG, Bojes HK, French SW: Expression of the peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease. Life Sci 1995; 56: 307-317
18. Salaspuro MP, Shaw S, Jayatilleke E, Ross WA, Lieber CS: Attenuation of the ethanol-induced hepatic redox change after chronic alcohol consumption in baboons: metabolic consequences in vivo and in vitro. Hepatology 1981; 1: 33-38
19. Wu D, Cederbaum AI: Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. J Biol Chem 1996; 271: 23914-23919
20. Kurose I, Higuchi H, Kato S, Miura S, Watanabe N, Kamegaya Y, Tomita K, Takaishi M, Horie Y, Fukuda M, Mizukami K, Ishii H: Oxidative stress on mitochondria and cell membrane of cultured rat hepatocytes and perfused liver exposed to ethanol. Gastroenterology 1997; 112: 1331-1343
21. Bailey SM, Cunningham CC: Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh, isolated rat hepatocytes. Hepatology 1998; 28: 1318-1326
22. Yokoyama H, Nagata S, Moriya S, Kato S, Ito T, Kamegaya K, Ishii H: Hepatic fibrosis produced in guinea pigs by chronic ethanol administration and immunization with acetaldehyde adducts. Hepatology 1995; 21: 1438-1442
23. Thurman RG: II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol 1998; 275: G605-611
24. Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM: Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci USA 1997; 94: 2557-2562
25. Hellerbrand C, Jobin C, Licato LL, Sartor RB, Brenner DA: Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells. Am J Physiol 1998; 275: G269-278
26. Yamauchi M, Potter JJ, Mezey E: Characteristics of alcohol dehydrogenase in fat-storing (Ito) cells of rat liver. Gastroenterology 1988; 94: 163-169
27. Casini A, Pellegrini G, Ceni E, Salzano R, Parola M, Robino G, Milani S, Dianzani MU, Surrenti C: Human hepatic stellate cells express class I alcohol dehydrogenase and aldehyde dehydrogenase but not cytochrome P4502E1. J Hepatol 1998; 28: 40-45
28. Pinzani M, Marra F, Carloni V: Signal transduction in hepatic stellate cells. Liver 1998; 18: 2-13
29. Schenker S: Medical consequences of alcohol abuse: is gender a factor? Alcohol Clin Exp Res 1997; 21: 179-181
30. Kwo PY, Ramchandani VA, O'Connor S, Amann D, Carr LG, Sandrasegaran K, Kopecky KK, Li TK: Gender differences in alcohol metabolism: relationship to liver volume and effect of adjusting for body mass. Gastroenterology 1998; 115: 1552-1557
31. Iimuro Y, Frankenberg MV, Arteel GE, Bradford BU, Wall CA, Thurman RG: Female rats exhibit greater susceptibility to early alcohol-induced liver injury than males. Am J Physiol 1997; 272: G1186-1194