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Volumn 30, Issue 5 SUPPL., 2002, Pages

Soluble thrombomodulin, plasma-derived unactivated protein C, and recombinant human activated protein C in sepsis

Author keywords

Activated protein C; Disseminated intravascular coagulation; Plasma derived protein C; Protein C; Sepsis; Shock; Soluble thrombomodulin; Thrombomodulin

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5A; BLOOD CLOTTING FACTOR 8A; PROTEIN C; THROMBIN; THROMBOMODULIN; VITAMIN K GROUP;

EID: 0036254955     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200205001-00023     Document Type: Conference Paper
Times cited : (51)

References (77)
  • 10
    • 0029937134 scopus 로고    scopus 로고
    • Sepsis/septic shock: Participation of the microcirculation: An abbreviated review
    • (1996) Crit Care Med , vol.24 , pp. 1072-1078
    • Hinshaw, L.B.1
  • 13
    • 0034651718 scopus 로고    scopus 로고
    • Introduction: Are natural anticoagulants candidates for modulating the inflammatory response to endotoxin?
    • (2000) Blood , vol.95 , pp. 1113-1116
    • Esmon, C.T.1
  • 14
  • 16
    • 0033373690 scopus 로고    scopus 로고
    • Sepsis and septic shock: Proinflammatory or anti-inflammatory state?
    • (1999) J Chemother , vol.11 , pp. 536-540
    • Antonelli, M.1
  • 20
    • 0031452476 scopus 로고    scopus 로고
    • Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock
    • (1997) Chest , vol.112
    • Dinarello, C.A.1
  • 23
    • 0024558370 scopus 로고
    • The roles of protein C and thrombomodulin in the regulation of blood coagulation
    • (1989) J Biol Chem , vol.264 , pp. 4743-4746
    • Esmon, C.T.1
  • 25
    • 0034007647 scopus 로고    scopus 로고
    • Changes of the hemostatic network in critically ill patients: Is there a difference between sepsis, trauma, and neurosurgery patients?
    • (2000) Crit Care Med , vol.28 , pp. 445-450
    • Boldt, J.1    Papsdorf, M.2    Rothe, A.3
  • 27
    • 0026534242 scopus 로고
    • Septic shock, multiple organ failure and disseminated intravascular coagulation: Compared patterns of antithrombin III, protein C, and protein S deficiencies
    • (1992) Chest , vol.101 , pp. 816-823
    • Fourrier, F.1    Chopin, C.2    Goudemand, J.3
  • 34
    • 0025963529 scopus 로고
    • Regulation of thrombomodulin by tumor necrosis factor-alpha: Comparison of transcriptional and posttranslational mechanisms
    • (1991) Blood , vol.77 , pp. 542-550
    • Lentz, S.R.1    Tsiang, M.2    Sadler, J.E.3
  • 36
    • 0024589205 scopus 로고
    • Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture
    • (1989) Blood , vol.73 , pp. 159-165
    • Moore, K.L.1    Esmon, C.T.2    Esmon, N.L.3
  • 38
    • 0034161458 scopus 로고    scopus 로고
    • Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo
    • (2000) Blood , vol.95 , pp. 1687-1693
    • Gu, J.M.1    Katsuura, Y.2    Ferrell, G.L.3
  • 39
    • 0031973176 scopus 로고    scopus 로고
    • Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: Lack of correlation with thrombomodulin suggests involvement of different pathological processes
    • (1998) Blood , vol.91 , pp. 725-727
    • Kurosawa, S.1    Stearns-Kurosawa, D.J.2    Carson, C.W.3
  • 41
    • 0033816062 scopus 로고    scopus 로고
    • Description of compensated and uncompensated disseminated intravascular coagulation (DIC) responses (non-overt and overt DIC) in baboon models of intravenous and intraperitoneal Escherichia coli sepsis and in the human model of endotoxemia: Toward a better definition of DIC
    • (2000) Crit Care Med , vol.28 , Issue.SUPPL.
    • Taylor F.B., Jr.1    Wada, H.2    Kinasewitz, G.3
  • 47
    • 0035222641 scopus 로고    scopus 로고
    • The normal role of APC in maintaining homeostasis and its relevance to critical illness
    • (2001) Crit Care , vol.5 , Issue.SUPPL.
    • Esmon, C.T.1
  • 49
    • 0033830963 scopus 로고    scopus 로고
    • The anticoagulant and anti-inflammatory roles of the protein C anticoagulant pathway
    • (2000) J Autoimmun , vol.15 , pp. 113-116
    • Esmon, C.T.1
  • 51
    • 0033880884 scopus 로고    scopus 로고
    • APC inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor-κB (NF-κB) and tumor necrosis factor-α (TNF-α) production in the THP-1 monocyte cell line
    • (2000) Br J Haematol , vol.110 , pp. 130-134
    • White, B.1    Schmidt, M.2    Murphy, C.3
  • 53
    • 0025763975 scopus 로고
    • Different glycoforms of human thrombomodulin: Their glycosaminoglycan-dependent modulatory effects on thrombin inactivation by heparin cofactor II and antithrombin III
    • (1991) Eur J Biochem , vol.198 , pp. 563-570
    • Koyama, T.1    Parkinson, J.F.2    Sie, P.3
  • 54
    • 0027320820 scopus 로고
    • Recombinant human soluble thrombomodulin delivers bounded thrombin to antithrombin III: Thrombomodulin associates with free thrombin and is recycled to activate protein C
    • (1993) Thromb Haemost , vol.70 , pp. 418-422
    • Aritomi, M.1    Watanabe, N.2    Ohishi, R.3
  • 57
    • 0032509527 scopus 로고    scopus 로고
    • Demonstration of the immature glycosaminoglycan tetrasaccharide sequence GlcAβ1-3Galβ1-3Galβ1-4Xyl on recombinant soluble human α-thrombomodulin. An oligosaccharide structure on a "part-time" proteoglycan
    • (1998) J Biol Chem , vol.273 , pp. 33728-33734
    • Nadanaka, S.1    Kitagawa, H.2    Sugahara, K.3
  • 59
    • 0033495730 scopus 로고    scopus 로고
    • New potential therapeutic modalities: APC
    • (1999) Sepsis , vol.3 , pp. 161-171
    • Esmon, C.T.1
  • 60
    • 0026569489 scopus 로고
    • The glycosaminoglycan of the recombinant human soluble thrombomodulin affects antithrombotic activity in a rat model of tissue factor-induced DIC
    • (1992) Thromb Haemost , vol.67 , pp. 366-370
    • Nawa, K.1    Itani, T.2    Ono, M.3
  • 61
    • 8544251325 scopus 로고    scopus 로고
    • The antithrombotic effects of recombinant human soluble thrombomodulin (rhsTM) on tissue factor-induced disseminated intravascular coagulation in crab-eating monkeys (Macaca fascicularis)
    • (1997) Blood Coagul Fibrinolysis , vol.8 , pp. 274-283
    • Mohri, M.1    Gonda, Y.2    Oka, M.3
  • 64
    • 0030034186 scopus 로고    scopus 로고
    • Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats
    • (1996) Blood , vol.87 , pp. 642-647
    • Uchiba, M.1    Okajima, K.2    Murakami, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.