Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo

Blood

Volumn 95, Issue 5, 2000, Pages 1687-1693

  Gu, Jian Ming ^b   Katsuura, Yasuhiro ^b   Ferrell, Gary L ^b   Grammas, Paula ^b   Esmon, Charles T ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; HIRUDIN; MESSENGER RNA; THROMBIN; THROMBIN INHIBITOR; THROMBOMODULIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; AORTA; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; INFLAMMATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; TISSUE DISTRIBUTION;

EID: 0034161458     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.5.1687.005k08_1687_1693     Document Type: Article

References (31)

1. Esmon CT. The rotes of protein C and thrombo-modulin in the regulation of blood coagulation. J Biol Chem. 1989;264:4743-4746.
2. Seligsohn U, Berger A, Abend M, et al. Homozygous protein C deficiency manifested by massive thrombosis in the newborn. New Engl J Med. 1984;310:559-562.
3. Dreyfus M, Magny JF, Bridey F, et al. Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate. New Engl J Med. 1991;325:1565-1568.
4. Taylor FB Jr, Chang A, Esmon CT, D'Angelo A, Vigano-D'Angelo S, Blick KE. Protein C prevents the coagulopathic and lethal effects of E. coli infusion in the baboon. J Clin Invest. 1987;79:918-925.
5. Smith OP, White B, Rafferty M. Successful treatment of meningococcal induced protein C deficiency/purpura fulminans in children with protein C concentrate and heparin [abstract]. Thromb Haemost. 1997;419(suppl). Abstract PS-1709.
6. Esmon CT, Schwarz HP. An update on clinical and basic aspects of the protein C anticoagulant pathway. Trends Cardiovasc Med. 1995;5:141-148.
7. Rivard GE, David M, Farrell C, Schwarz HP. Treatment of purpura fulminans in meningococcemia with protein C concentrate. J Pediatr. 1995;126:646-652.
8. Grey ST, Tsuchida A, Hau H, Orthner CL, Salem HH, Hancock WW. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester. J Immunol. 1994;153:3664-3672.
9. Grinnell BW, Hermann RB, Van SB. Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide. Glycobiology. 1994;4:221-226.
10. Fukudome K, Esmon CT. Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem. 1994;269:26,486-26,491.
11. Bangalore N, Drohan WN, Orthner CL High affinity binding sites for activated protein C and protein C on cultured human umbilical vein endothelial cells independent of protein S and distinct from known ligands. Thromb Haemost. 1994;72:465-474.
12. Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, Ferrell GL, Esmon CT. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci USA. 1996;93:10,212-10,216.
13. Regan LM, Stearns-Kurosawa DJ, Kurosawa S, Mollica J, Fukudome K, Esmon CT. The endothelial cell protein C receptor: inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors. J Biol Chem. 1996;271:17,499-17,503.
14. Laszik Z, Mitro A, Taylor FB Jr, Ferrell G, Esmon CT. Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway. Circulation. 1997;96:3633-3640.
15. Fukudome K, Esmon CT. Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR. J Biol Chem. 1995;270:5571-5577.
16. Taylor F, Chang A, Ferrell G, et al. C4b-binding protein exacerbates the host response to Escherichia coli. Blood. 1991;78:357-363.
17. Hancock WW, Tsuchida A, Hau H, Thomson NM, Salem HH. The anticoagulants protein C and protein S display potent anti-inflammatory and immunosuppressive effects relevant to transplant biology and therapy. Transplant Proc. 1992;24:2302-2303.
18. Gu JM, Esmon CT. Functional characterization of 5′-flanking region of the mouse endothelial protein C receptor (EPCR) gene [abstract]. Mol Biol Cell. 1997;8(suppl):228a.
19. Owen WG, Esmon CT, Jackson CM. The conversion of prothrombin to thrombin: I: characterization of the reaction products formed during the activation of bovine prothrombin. J Biol Chem. 1974;249:594-605.
20. Diglio CA, Liu W, Grammas P, Giacomelli F, Wiener J. Isolation and characterization of cerebral resistance vessel endothelium in culture. Tissue Cell. 1993;25:833-846.
21. Hyman R, Lesley J, Schulte R. Somatic cell mutants distinguish CD44 expression and hyaluronic acid binding. Immunogenetics. 1991;33:392-395.
22. Yao L, Pan J, Setiadi H, Patel KD, McEver RP. Interleukin 4 or oncostatin M induces a prolonged increase in P-selectin mRNA and protein in human endothelial cells. J Exp Med. 1996;184:81-92.
23. Fukudome K, Kurosawa S. Stearns-Kurosawa DJ, He X, Rezaie AR, Esmon CT. The endothelial cell protein C receptor: cell surface expression and direct ligand binding by the soluble receptor. J Biol Chem. 1996;271:17,491-17,498.
24. Taylor FB Jr, Stearns-Kurosawa DJ, Kurosawa S, et al. The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Blood. In press.
25. Beutler B, Milsark IW, Cerami AC. Passive immunization against cachectin/tumor necrosis factor protects mice from the lethal effect of endotoxin. Science. 1985;229:869-871.
26. Kahn ML, Zheng Y-W, Huang W, et al. A dual thrombin receptor system for platelet activation. Nature. 1998;394:690-694.
27. Nystedt S, Larrsson AK, Aberg H, Sundelin J. The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and function expression. J Biol Chem. 1995;270:5950-5955.
28. Xu J, Qu D, Esmon NL, Esmon CT. Metalloproteolytic release of endothelial cell protein C receptor. J Biol Chem. In press.
29. Kurosawa S, Stearns-Kurosawa DJ, Hidari N, Esmon CT. Identification of functional endothelial protein C receptor in human plasma. J Clin Invest. 1997;100:411-418.
30. Kurosawa S, Stearns-Kurosawa DJ, Carson CW, D'Angelo A. Della Valle P. Esmon CT. Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombo-modulin suggests involvement of different pathological processes. Blood. 1998;91:725-727.
31. Stearns-Kurosawa DJ, Esmon CT, Kurosawa S. The endothelial protein C receptor, neutrophil, proteinase-3 and Wegener's granulomatosis [abstract]. Thromb Haemost. Aug 1999(suppl);215.