Changes of the hemostatic network in critically ill patients - Is there a difference between sepsis, trauma, and neurosurgery patients?

Critical Care Medicine

Volumn 28, Issue 2, 2000, Pages 445-450

  Boldt, Joachim ^a   Papsdorf, Michael ^a   Rothe, Alf ^b   Kumle, Bernhard ^a   Piper, Sven ^a  

^a KLINIKUM LUDWIGSHAFEN   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Coagulation; Critically ill; Endothelium; Fibrinolysis; Hemostasis; Neurosurgery; Protein C; Protein S; Sepsis; Thrombomodulin; Trauma patient

Indexed keywords

ANTITHROMBIN III; FIBRINOGEN; THROMBIN ANTITHROMBIN COMPLEX;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; CLINICAL ARTICLE; CRITICAL ILLNESS; DISEASE SEVERITY; FEMALE; HEMOSTASIS; HUMAN; MALE; NEUROSURGERY; PATIENT MONITORING; PRIORITY JOURNAL; SEPSIS; TRAUMATIC SHOCK;

EID: 0034007647     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200002000-00026     Document Type: Article

References (32)

1. 1. Webb AR, Mythen MG, Jacobson D, et al: Maintaining blood flow in the extracorporeal circuit: Haemostasis and anticoagulation. Intensive Care Med 1995; 21:84-93
2. 2. Fourrier F, Jourdain M, Tournois A, et al: Coagulation inhibitor substitution during sepsis. Intensive Care Med 1995; 21: S264-S268
3. 3. Bone RC: Sepsis and coagulation an important link. Chest 1992; 101:594-595
4. 4. Thijs LG, de Boer JP, Groot MCM, et al: Coagulation disorders in septic shock. Intensive Care Med 1993; 19:S8-S15
5. 5. Williams TJ, Hellewell PG: Endothelial cell biology. Am Rev Respir Dis 1992; 146:S45-S50
6. 6. Esmon D, Esposito C, Gerlach H, et al: Endothelium and regulation of coagulation. Diab Care 1991; 14(Suppl 2):160-166
7. 7. Gerlach H, Esposito C, Stern D: Modulation of endothelial hemostatic properties: An active role in the host response. Annu Rev Med 1990; 41:15-24
8. 8. Preissner KT: Anticoagulant potential of endothelial cell membrane components. Haemostasis 1988; 18:271-306
9. 9. Fareed J, Bick RL, Hoppensteadt DA, et al: Molecular markers of hemostatic activation: Applications in the diagnosis of thrombosis and vascular and thrombotic disorders. Clin Appl Thromb Hemost 1995; 1:87-102
10. 10. Levi M, ten Cate H, van der Poll T, et al: Pathogenesis of disseminated intravascular coagulation in sepsis. JAMA 1993; 270: 975-979
11. 11. Leithäuser B, Matthias FR, Nicolai U, et al: Hemostatic abnormalities and the severity of illness at the onset of clinically defined sepsis. Intensive Care Med 1996; 22:631-636
12. 12. Scherer RU, Spangenberg P: Procoagulant activity in patients with isolated severe head trauma. Crit Care Med 1998; 26:149-156
13. 13. Baker SP, O'Neill B: The injury severity score. An update. J Trauma 1976; 16:882-888
14. 14. American College of Chest Physicians/ Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874
15. 15. Amiral J, Adam M, Mimilia F, et al: A new assay for soluble forms of thrombomodulin in plasma. Thromb Haemostas 1991; 65:947
16. 16. Boffa MC, Karochkine, Berad M: Plasma thrombomodulin as a marker of endothelium damage. Nouv Rev Fr Hematol 1991; 33:529-30
17. 17. Lorente JA, García-Frade J, Landin L, et al: Time course of hemostatic abnormalities in sepsis and its relation to outcome. Chest 1993; 103:1536-1542
18. 18. Okajima K, Yang WP, Okabe H, et al: Role of leukocytes in the activation of intravascular coagulation in patients with septicemia. Am J Hematol 1991; 36:265-271
19. 19. Bone RC: Modulators of coagulation a critical appraisal of their role in sepsis. Arch Intern Med 1992; 152:1381-1389
20. 20. Philippé J, Offner F, Declerck PJ, et al: Fibrinolysis and coagulation in patients with infectious disease and sepsis. Thromb Haemost 1991; 65:291-295
21. 21. Voss R, Matthias FR, Borkowski G, et al: Activation and inhibition of fibrinolysis in septic patients in an internal intensive care unit. Br J Haematol 1990; 75:99-105
22. 22. Takahashi H, Tatewaki W, Wada K, et al: Thrombin versus plasmin generation in disseminated intravascular coagulation associated with various underlying disorders. Am J Hematol 1990; 33:90-95
23. 23. Chandler WL, Allessi MC, Aillaud MF, et al: Clearance of tissue plasminogen activator (TPA) and TPA/plasminogen activator inhibitor type I (PAI-1) complex: Relationship to elevated TPA antigen in patients with high PAI-1 activity levels. Circulation 1997; 96:761-768
24. 24. Suffredini AF: Current prospects for the treatment of clinical sepsis. Crit Care Med 1994; 22:S12-S14
25. 25. Dittman WA: Thrombomodulin. Biological and cardiovascular applications. Trends Cardiovasc Med 1991; 1:331-336
26. 26. Mann KG, Krishnaswamy S, Lawson JH: Surface-dependent hemostasis. Semin Hematol 1992; 29:213-226
27. 27. Uchiyama H, Ohtani H, Hiraishi S, et al: Changes in plasma thrombomodulin antigen in rabbit developing endotoxin-induced disseminated intravascular coagulation and the effect of heparin. Thromb Res 1992; 65: 593-604
28. 28. Hesselvik JF, Malm J, Dahlback M, et al: Protein C, protein S and C4b-binding protein in severe infection and septic shock. Thromb Haemost 1991; 65:126-129
29. 29. Leclerc F, Hazelet J, Jude B, et al: Protein C and S deficiency in severe infectious purpura in children: A collaborative study of 40 cases. Intensive Care Med 1992; 18:201-205
30. 30. Boldt J, Menges T, Wollbrück M, et al: Continuous hemofiltration and platelet function in critically ill patients. Crit Care Med 1994; 22:1155-1160
31. 31. Bick RL: Platelet function defects: A clinical review. Semin Thromb Hemost 1992; 18: 167-185
32. 32. Messmore HL Jr, Walenga JM, Fareed J: Molecular markers of platelet activation. Semin Thromb Hemost 1984; 10:264-269