The anticoagulant and anti-inflammatory roles of the protein C anticoagulant pathway

Journal of Autoimmunity

Volumn 15, Issue 2, 2000, Pages 113-116

  Esmon, Charles T ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Autoantibodies; Inflammation; Protein C; Thrombosis; Vessel wall

Indexed keywords

ANTICOAGULANT AGENT; AUTOANTIBODY; BLOOD CLOTTING FACTOR 10A; CYTOKINE; ENDOTOXIN; PROTEIN C; THROMBIN;

ARTERY THROMBOSIS; BLOOD CLOTTING; CELL ACTIVATION; CONFERENCE PAPER; DOWN REGULATION; ENDOTHELIUM; ENDOTHELIUM CELL; HUMAN; INFLAMMATION; LEUKOCYTE ADHERENCE; MICROCIRCULATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; TRANSCRIPTION REGULATION; VEIN THROMBOSIS;

EID: 0033830963     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.2000.0400     Document Type: Conference Paper

References (30)

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2. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex
3. Human protein C receptor is presently primarily on endothelium of large blood vessels: Implications for the control of the protein C pathway
4. Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex
5. Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex
6. The effect of membrane composition on the hemostatic balance
7. In vivo and in vitro complexes of activated protein C with two inhibitors in baboons
8. TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex
9. Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells
10. Release of thrombomodulin from endothelial cells by concerted action of TNF-α and neutrophils: In vivo and in vitro studies
11. Metalloproteolytic release of endothelial cell protein C receptor
12. Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity
13. Plasma thrombomodulin in Wegener's granulomatosis as an indicator of vascular injuries
14. Inhibition of protein Ca cofactor function of human and bovine protein S by C4b-binding protein
15. Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains
16. Functional and immunologic protein S levels are decreased during pregnancy
17. Oral contraceptives and venous thrombosis: Different sensitivities to activated protein C in women using second- and third-generation oral contraceptives
18. On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies
19. Recovery from endotoxin shock after extracorporeal perfusion without anticoagulation
20. A model for thrombin protection against endotoxin
21. Protein C prevents the coagulopathic and lethal effects of E. coli infusion in the baboon
22. Recombinant human activated protein (rhAPC) improves coagulation abnormalities associated with severe sepsis
23. The anticoagulants protein C and protein S display potent anti-inflammatory and immunosuppressive effects relevant to transplant biology and therapy
24. Epidemic meningococcemia and purpura fulminans with induced protein C deficiency
25. C4b-binding protein exacerbates the host response to Escherichia coli
26. Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses
27. Human protein C inhibits selectin-mediated Cell adhesion: Role of unique fucosylated o1igosaccharide
28. Recombinant thrombomodulin prevents endotoxin-induced lung injury in rats by inhibiting leukocyte activation
29. Endothelial cell protein C receptor (EPCR) constitutively translocates into the nucleus and also mediates activated protein C, but not protein C, nuclear translocation
30. The soluble endothelial protein C receptor binds to a proteinase-3/MAC-1 heterocomplex on neutrophils