The endothelial cell proten C receptor aids in host defense against Escherichia coli sepsis

Blood

Volumn 95, Issue 5, 2000, Pages 1680-1686

  Taylor Jr , Fletcher B ^a   Stearns Kurosawa, D J ^b   Kurosawa, S ^b   Ferrell, G ^b   Chang, A C K ^b   Laszik, Z ^b   Kosanke, S ^b   Peer, G ^b   Esmon, C T ^b  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; FIBRINOGEN; INTERLEUKIN 6; INTERLEUKIN 8; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; THROMBIN ANTITHROMBIN COMPLEX; TUMOR NECROSIS FACTOR ALPHA; ACTIVATED PROTEIN C RECEPTOR; ALPHA 1 ANTITRYPSIN; ANTITHROMBIN III; ANTITHROMBIN III PROTEASE COMPLEX; ANTITHROMBIN III-PROTEASE COMPLEX; BLOOD CLOTTING FACTOR; CELL SURFACE RECEPTOR; INTERLEUKIN DERIVATIVE; LEUKOCYTE ELASTASE; PEPTIDE HYDROLASE; THROMBOMODULIN; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; ENDOTHELIUM CELL; ESCHERICHIA COLI; GRAM NEGATIVE INFECTION; HOST RESISTANCE; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SEPSIS; ANIMAL; BLOOD; BLOOD CLOTTING DISORDER; COMPARATIVE STUDY; ENTEROBACTER INFECTION; IMMUNOLOGY; LUNG; MICROBIOLOGY; MULTIPLE ORGAN FAILURE; PAPIO; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; VISCERA;

ALPHA 1-ANTITRYPSIN; ANIMALS; ANTIBODIES, MONOCLONAL; ANTITHROMBIN III; BLOOD COAGULATION DISORDERS; BLOOD COAGULATION FACTORS; ESCHERICHIA COLI INFECTIONS; INTERLEUKINS; LEUKOCYTE ELASTASE; LUNG; MULTIPLE ORGAN FAILURE; PAPIO; PEPTIDE HYDROLASES; RECEPTORS, CELL SURFACE; SEPSIS; THROMBOMODULIN; TISSUE PLASMINOGEN ACTIVATOR; TUMOR NECROSIS FACTOR-ALPHA; VISCERA;

EID: 0034145311     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.5.1680.005k33_1680_1686     Document Type: Article

References (52)

1. Esmon CT. The roles of protein C and thrombomodulin in the regulation of blood coagulation. J Biol Chem. 1989;264:4743.
2. Bajzar L, Morser J, Nesheim M. TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex. J Biol Chem. 1996;271:16,603.
3. Lane DA, Mannucci PM, Bauer KA, et al. Inherited thrombophilia: part 2. Thromb Haemost. 1996;76:824.
4. Lane DA, Mannucci PM, Bauer KA, et al. Inherited thrombophilia: part 1. Thromb Haemost. 1996;76:651.
5. Dreyfus M, Magny JF, Bridey F, et al. Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate. N Engl J Med. 1991;325:1565.
6. Griffin JH, Mosher DF, Zimmerman TS, Kleiss AJ. Protein C, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation. Blood. 1982;60:261.
7. Powars DR, Rogers ZR, Patch MJ, McGehee WG, Francis RB. Purpura fulminans in meningococcemia: association with acquired deficiencies of proteins C and S [Letter]. N Engl J Med. 1987;317:571.
8. Nawroth PP, Handley DA, Esmon CT, Stern DM. Interleukin-1 induces endothelial cell procoagulant while suppressing cell surface anticoagulant activity. Proc Natl Acad Sci USA. 1986;83:3460.
9. Nawroth PP, Stern DM. Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J Exp Med. 1986;163:740.
10. Moore KL, Andreoli SP, Esmon NL, Esmon CT, Bang NU. Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. J Clin Invest. 1987;79:124.
11. Conway EM, Rosenberg RD. Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol Cell Biol. 1988;8: 5588.
12. Lentz SR, Tsiang M, Sadler JE. Regulation of thrombomodulin by tumor necrosis factor-α: comparison of transcriptional and posttranscriptional mechanisms. Blood. 1991;77:543.
13. Takano S, Kimura S, Ohdama S, Aoki N. Plasma thrombomodulin in health and diseases. Blood. 1990;76:2024.
14. Taylor FB Jr, Chang A, Esmon CT, D'Angelo A, Vigano-D'Angelo S, Blick KE. Protein C prevents the coagulopathic and lethal effects of E. coli infusion in the baboon. J Clin Invest. 1987;79:918.
15. Taylor F, Chang A, Ferrell G, et al. C4b-binding protein exacerbates the host response to Escherichia coli. Blood. 1991;78:357.
16. Gonda Y, Hirata S, Saitoh K-I, et al. Antithrombotic effect of recombinant human soluble thrombomodulin on endotoxin-induced disseminated intravascular coagulation in rats. Thromb Res. 1993;71:325.
17. Hasegawa N, Kandra TG, Husari AW, et al. The effects of recombinant human thrombomodulin on endotoxin-induced multiple-system organ failure in rats. Am J Respir Crit Care Med. 1996;153:1831.
18. Uchiba M, Okajima K, Murakami K, Nawa K, Okabe H, Takatsuki K. Recombinant human soluble thrombomodulin reduces endotoxin-induced pulmonary vascular injury via protein C activation in rats. Thromb Haemost. 1995;74:1265.
19. Uchiba M, Okajima K, Murakami K, Johno M, Okabe H, Takatsuki K. Recombinant thrombomodulin prevents endotoxin-induced lung injury in rats by inhibiting leukocyte activation. Am J Physiol. 1996;271:L470
20. Uchiba M, Okajima K, Murakami K, et al. rhs-TM prevents ET-induced increase in pulmonary vascular permeability through protein C activation. Am J Physiol. 1997;273:L889.
21. Hancock WW, Tsuchida A, Hau H, Thomson NM, Salem HH. The anticoagulants protein C and protein S display potent anti-inflammatory and immunosuppressive effects relevant to transplant biology and therapy. Transplant Proc. 1992;24:2302.
22. Taoka Y, Okajima K, Uchiba M, et al. Activated protein C reduces the severity of compression-induced spinal cord injury in rats by inhibiting activation of leukocytes. J Neurosci. 1998;18:1393.
23. Rintala E, Seppala O-P, Kotilainen P, Rasi V. Protein C in the treatment of coagulopathy in meningococcal disease. Lancet. 1996;347:1767.
24. Smith OP, White B, Vaughan D, et al. Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans. Lancet. 1997;350:1590.
25. Gereon WT, Dickerman JD, Bovill EG, Golden E. Severe acquired protein C deficiency in purpura fulminans associated with disseminated intravascular coagulation: treatment with protein C concentrate. Pediatrics. 1993;91:418.
26. Fukudome K, Esmon CT. Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem. 1994;269:26,486.
27. Laszik Z, Mitro A, Taylor FB Jr, Ferrell G, Esmon CT. Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway. Circulation. 1997;96:3633.
28. Fukudome K, Kurosawa S, Stearns-Kurosawa DJ, He X, Rezaie AR, Esmon CT. The endothelial cell protein C receptor: cell surface expression and direct ligand binding by the soluble receptor. J Biol Chem. 1996;271:17,491.
29. Xu J, Esmon NL, Esmon CT. Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation. J Biol Chem. 1999;274:6704.
30. Steams-Kurosawa DJ, Kurosawa S, Mollica JS, Ferrell GL, Esmon CT. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci USA. 1996;93:10,212.
31. Regan LM, Stearns-Kurosawa DJ, Kurosawa S, Mollica J, Fukudome K, Esmon CT. The endothelial cell protein C receptor: inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors. J Biol Chem. 1996;271:17,499.
32. Kurosawa S, Stearns-Kurosawa DJ, Hidari N, Esmon CT. Identification of functional endothelial protein C receptor in human plasma. J Clin Invest. 1997;100:411.
33. Kurosawa S, Stearns-Kurosawa DJ, Carson CW, D'Angelo A, Delia Valle P, Esmon CT. Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes. Blood. 1998;91:725.
34. Hinshaw LB, Brackett DJ, Archer LT, Beller L, Wilson MF. Detection of 'hyperdynamic state' of sepsis in the baboon during lethal E. coli infusion. J Trauma. 1983;23:361.
35. Taylor FB Jr. Baboon models of three variants of the hemostatic response to the inflammatory stimuli. In: Brigham K, ed. Endotoxin and the Lungs. New York, NY: Dekker;1993:171.
36. 100 Escherichia coli. Blood. 1998;91:1609.
37. Taylor FB Jr, He SE, Chang ACK, et al. Infusion of phospholipid vesicles amplifies the local thrombotic response to TNF and anti-protein C into a consumptive response Thromb Haemost. 1996;75:578.
38. Nuijens JH, Abbink JJ, Wachtfogel YT, et al. Plasma elastase alpha 1-antitrypsin and lactoferrin in sepsis: evidence for neutrophils as mediators in latal sepsis. J Lab Clin Med. 1992;119:159.
39. de Boer JP, Creasey AA, Chang ACK, et al. Activation patterns of coagulation and fibrinolysis in baboons following infusion with a lethal or sublethal dose of E. coli. Circ Shock. 1993;39:59.
40. Sumida Y, Wada H, Fujii M, et al. Increased soluble fibrin monomer and soluble thrombomodulin levels in non-insulin dependent diabetes mellitus. Blood Coagul Fibrinol. 1997;8:303.
41. Laszik Z, Carson CW, Nadasdy T, et al. Lack of suppressed renal thrombomodulin expression in a septic rat model with glomerular thrombotic microangiopathy. Lab Invest. 1994;70:862.
42. Gruber A, Griffin JH. Direct detection of activated protein C in blood from human subjects. Blood. 1992;79:2340.
43. Wellcome Research Laboratories. Fibrinogen Degradation Products. Thombo-Wellcotest (Rapid Latex Kit). Purley, Surrey, UK: Southern Press; 1984.
44. Hougie C. Methods of estimating fibrinogen concentration-thrombin time test. In: Williams WJ, Beutler E, Erslev AJ, Lichtman MA, eds. Hematology. New York, NY: McGraw-Hill; 1983:1667.
45. Eastman Kodak Co. Technical Information in Test Methodologies. Rochester, NY; 1985.
46. Spayd RW, Bruschi B, Burdick BA, et al. Multilayer film elements for clinical analysis: applications to representative chemical determinations. Clin Chem. 1978;24:1343.
47. Wroblewski F, LaDue JS. Serum glutamic pyruvate transaminase in cardiac and hepatic disease. Proc Soc Exp Biol Med. 1956;91:569.
48. Taylor FB Jr, Esmon CT, Hinshaw LB. Summary of staging mechanism and intervention studies in the baboon model of E. coli sepsis. J Trauma. 1990;30:S197.
49. Lentz SR, Fernandez JA, Griffin JH, et al. Impaired anticoagulant response to infusion of thrombin in atherosclerotic monkeys associated with acquired defects in the protein C system. Arterioscler Thromb Vase Biol. 1999;19:1744.
50. Stearns-Kurosawa DJ, Esmon CT, Kurosawa S. The endothelial protein C receptor, neutrophil, proteinase-3 and Wegener's granulomatosis [abstract]. Thromb Haemost. 1999:215. Abstract 677.
51. Johnson K, Choi Y, DeGroot E, Samuels I, Creasey A, Aarden L. Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation. J Immunol. 1998;160:5130.
52. Faust SN, Heyderman RS, Harrison O, et al. Molecular mechanisms of thrombosis in meningococcal septicaemia: the role of the protein C pathway in vivo [abstract]. 2nd Annual Meeting of the British Infection Society, London 1999.