Proteolytic response to oxidative stress in mammalian cells

Biological Chemistry

Volumn 383, Issue 3-4, 2002, Pages 559-567

  Mehlhase, Jana ^a   Grune, Tilman ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Calpains; Lysosomes; Proteasome; Protein oxidation; Proteolysis

Indexed keywords

CALPAIN; CASPASE; NITRIC OXIDE; PROTEASOME; PROTEINASE; REACTIVE OXYGEN METABOLITE;

AEROBIC METABOLISM; ANIMAL CELL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; HUMAN; HUMAN CELL; LYSOSOME; MAMMAL CELL; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN FUNCTION; PROTEIN MODIFICATION; SHORT SURVEY;

ANIMALS; CELL PHYSIOLOGY; ENDOPEPTIDASES; HUMANS; MAMMALS; OXIDATIVE STRESS;

ANIMALIA; MAMMALIA;

EID: 0036254702     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.057     Document Type: Short Survey

References (123)

1. Effect of oxidant system on the ubiquitylation of proteins in the central nervous system
2. 2+-dependent proteolysis in rabit lens epithelium after oxidative stress
3. The hydrophobic effect contributes to polyubiquitin chain recognition
4. Protein oxidation in aging, disease, and oxidative stress
5. The Lon protease appears to be primarily responsible for degradation of oxidatively-denaturated aconitase in mitochondria
6. Subcellular localization of proteasome and their regulatory complexes in mammalian cells
7. Responses to peroxynitrite in yeast: Glycerinaldehyd-3-phosphat dehydrogenase (GAPDH) as a sensitive intracellular target for nitration and enhancement of chaperone expression and ubiquitination
8. From cytoprotection to tumor suppression: The multifactorial role of peroxiredoxins
9. Modulation of the hydrophobicity of glutamine synthetase by mixed function oxidation
10. Caspase and calpain substrates: Roles in synaptic plasticity and cell death
11. Conjugation of ubiquitin to denatured hemoglobin is proportional of the rate of hemoglobin degradation in HeLa cells
12. Oxidative stress and Alzheimer disease
13. The ubiquitin-proteasome proteolytic pathway
14. Structure and functions of the 20S and 26S proteasomes
15. Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation
16. Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat
17. Antioxidants J811 and 17-β-estradiol protect cerebellar granule cells from methylmercury-induced apoptotic cell death
18. Protein damage and degradation by oxygen radicals: I. General aspects
19. Degradation of oxidized proteins by the 20S proteasome
20. Protein damage and degradation by oxygen radicals: III. Modification of secondary and tertiary structure
21. Oxygen radicals stimulate proteolysis and lipid peroxidation by independent mechanisms in erythrocytes
22. Proteins damaged by oxygen radicals are rapidly degraded in extracts of red blood cells
23. Protein damage and degradation by oxygen radicals: II. Modification of amino acids
24. Protein damage and degradation by oxygen radicals: IV. Degradation of denatured protein
25. Concerning a possible mechanism for selective capture of cytoplasmic proteins by lysosomes
26. Direct evidence of importance of lysosomes in degradation of intracellular proteins
27. Biochemistry and pathology of radical-mediated protein oxidation
28. Liver mitochondria contain an ATP-dependent, vanadate-sensitive pathway or the degradation of proteins
29. Hydrogen peroxide reversible inhibits epidermal groth factor (EGF) receptor internalization and coincident ubiquitination of EGF receptor and Eps15
30. Cholesterol delivered to macrophages by oxidized low density lipoprotein is sequestered in lysosomes and fails to efflux normally
31. Relationship between in vivo degradative rates and isoelectric points of proteins
32. The proteasome (multi-catalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins
33. Mechanism of alcoholic liver injury
34. Protein oxidation and proteolysis in RAW264.7 macrophages: Effects of PMA activation
35. Dityrosine and tyrosine oxidation products are endogenous markers for the selective proteolysis of proteasome
36. Dityrosine: A marker for oxidatively modified proteins and selective proteolysis
37. Exposure of hydrophobic moieties promotes the selective degradation of hydrogen peroxide-modified hemoglobin by multicatalytic proteinase complex, proteasome
38. New insights into the mechanisms and importance of the proteasome in intracellular protein degradation
39. Accelerated endocytosis and incomplete catabolism of radical-damaged protein
40. Protein degradation in cultured liver epithelial cells during oxidative stress: Role of the multicatalytic proteinase complex, proteasome
41. Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome
42. Degradation of oxidized proteins in mammalian cells
43. Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome
44. Protein oxidation and proteolysis by the nonradical oxidants singlet oxygen or peroxynitrite
45. Oxidative stress inhibits calpain activity in situ
46. The protein substrate binding site of the ubiquitin-protein ligase system
47. Getting down with ubiquitin: Turning off cell-surface receptors, transporters and channels
48. A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation system
49. Purification of two high molecular weight proteases from rabbit reticulocyte lysate
50. Degradation of differentially oxidized α-crysatllins in bovine lens epithelial cells
51. Activation of calpain precedes morphological alterations during hydrogen peroxide-induced apoptosis in neuronally differenciated mouse embryonal carcinoma P19 cell line
52. ATP-dependent protease in human placenta
53. Regulation of ubiquitin-conjugating enzymes by glutathione following oxidative stress
54. The intracellular storage and turnover of apolipoprotein B of oxidized LDL in macrophages
55. Protein degradation in mitochondria
56. The inhibitory effect of prostaglandin E1 on oxidative stress-induced hepatocyte injury evaluated by calpain-μ activation
57. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly
58. Expression of caspases and their substrates in the rat model of focal cerebral ischemia
59. Regulated protein degradation in mitochondria
60. Hydrogen peroxide-induced structural alterations of RNaseA
61. Synergistic cytotoxic interactions between sodium butyrat, MG132 and camptothecin in human retinoblastoma Y79 cells
62. Gene expression profile of ageing and its retardation by caloric restriction
63. Discrimination between ubiquitin-dependent and ubiquitin-independent proteolytic pathways by the 26S proteasome subunit 5a
64. Mitochondria contain a proteolytic system which recognize and degrade oxidatively-denatured proteins
65. White matter damage following systemic injection of the mitochondrial inhibitor 3-nitropropionic acid in rat
66. LPS-induced protein oxidation and proteolysis in BV-2 microglial cells
67. Expression of mitochondrial marker proteins during spermiogenesis
68. Proteolysis of oxidized proteins and cellular senescence
69. Calpain activation in plasma membrane bleb formation during ter-butyl-hydroperoxide-induced rat hepatocyte injury
70. Calpain: A cytosolic proteinase active at the membranes
71. Redox regulation of ubiquitin-conjugating enzymes: Mechanistic insights using the thiol-specific oxidant diamide
72. 4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress
73. Protein degradation as an index of oxidative stress
74. Protein, lipid and DNA repair systems in oxidative stress: The free radical theory of aging revisited
75. Macroxyproteinase (M.O.P.): A 670 kDa proteinase complex that degrades oxidatively denatured proteins in red blood cells
76. Hydrophobicity as the signal for selective degradation of hydroxyl radical modified hemoglobin by the multicatalytic proteinase complex, proteasome
77. Proteasomes: Protein degradation machines of the cell
78. Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular protein degradation by autophagy
79. 4-induced oxidative stress
80. Oxidative stress increases ubiquitin-protein conjugates in synaptosomes
81. Characteristics of an ATP-dependent proteolytic system of rat liver mitochondria
82. Diverse stimuli induce calpain overexpression and apoptosis in C6 glioma cells
83. 2+ influx upregulate and induce apoptosis in PC12 cells
84. Comparative resistance of 20S and 26S proteasome to oxidative stress
85. Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress
86. Preferential degradation of the oxidatively modified form of glutamine synthetase by intracellular mammalian proteases
87. Purification of a liver alkine protease which degrades oxidatively modified glutamine synthetase: Characterization as a high molecular weight cysteine proteinase
88. Proteasomes: Multicatalytic proteinase complexes
89. A pre-embedding technique for immunohistochemical visualisation of cathepsin D in cultured cells subjected to oxidative stress
90. Oxidative stress cause relocation of lysosomal enzymes cathepsin D with ensuing apoptosis in neuronal rat cardiomyocytes
91. Inhibitors of proteasome block the degradation of most cell proteins and the generation of peptides on MHC class I molecules
92. Protein degradation in rat liver during postnatal development
93. Protein degradation in rat liver. Evidence for populations of protein degradation rates in cellular organelles
94. Subcellular localization, stoichiometry, and protein levels of 26S proteasome subunits in yeast
95. Superoxide dismutase undergoes proteolysis and fragmentation following oxidative modification and inactivation
96. Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of IκBα in NFκB activation by oxidative stress
97. Rapid degradation of Prxl and PrxII induced by silica in Rat2 cells
98. Oxidative stress and recovery from oxidative stress are associated with altered ubiquitin conjugating and proteolytic activities in bovine lens epithelial cells
99. Degradation of native and oxidized β- and γ-crystallins using bovine lens epithelial cell and rabbit reticulocyte
100. Removal of oxidatively damaged proteins from lens cells by the ubiquitin-proteasome pathway
101. Monoubiquitin carries a novel internalization signal that is appended to activated receptors
102. 4-Hydroxynonenal-modified amyloid-β peptide inhibits the proteasome: Possible importance for Alzheimer's disease
103. Proteasome-dependent degradation of oxidized proteins in MRC-5 fibroblasts
104. Proteasome inhibition by lipofuscin/ceroid during postmitotic ageing of fibroblasts
105. Early caspase activation in leukemic cells subject to etoposide-induced G2-M arrest: Evidence of commitment to apoptosis rather than mitotic cell death
106. Oxidation of proteins by mixed-function oxidation systems: Implication in protein turnover, aging and neutrophil function
107. Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions
108. Metal-catalyzed oxidation of proteins: Physiological consequences
109. Novel targets for therapeutic intervention against ischemic brain injury
110. Proteasomes: Structure and biology
111. ATP serves two distinct roles in protein degradation in reticulocytes, one requiring and one independent of ubiquitin
112. Ceroid/lipofuscin formation in cultured human fibroblasts: The role of oxidative stress and lysosomal proteolysis
113. Recognition of the polyubiquitin proteolytic signal
114. Metal-catalyzed oxidation of bovine neurofilaments in vitro
115. Influence of DNA binding on the degradation of oxidized histones by the 20S proteasome
116. Poly-ADP-ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones
117. Turnover of oxidatively damaged nuclear proteins in BV-2 microglial cells is linked to their activation state by poly-ADP-ribose polymerase
118. The 26S proteasome: A machine designed for controlled proteolysis
119. Relative rate of turnover of subunits of mitochondrial proteins
120. A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease
121. ATP-dependent protease in bovine adrenal cortex. Tissue specificity, subcellular localization and partial characterization
122. In vivo assembly of the proteasomal complexes, implications for antigen processing
123. +-ATPase to intracellular proteinases