Novel targets for therapeutic intervention against ischemic brain injury

Clinical Neuropharmacology

Volumn 22, Issue 3, 1999, Pages 164-171

  Sun, Anyang ^a   Cheng, Jieshi ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Calpain; Caspases; Cerebral ischemia; DNA damage; Glycine; Inflammation mediators; Poly(ADP ribose) polymerase; Reperfusion injury

Indexed keywords

6,7 DIBROMO 5 NITRO 2,3 QUINOXALINEDIONE; 6,7 DICHLORO 5 NITRO 2,3 QUINOXALINEDIONE; [1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER; CALPAIN; CASPASE; DIZOCILPINE; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; NEUROPROTECTIVE AGENT; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; TRAXOPRODIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; DNA DAMAGE; DRUG RESEARCH; LEUKOCYTE ADHERENCE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; REPERFUSION INJURY;

ANIMALS; BRAIN ISCHEMIA; CALPAIN; CASPASES; DNA DAMAGE; INFLAMMATION MEDIATORS; KYNURENIC ACID; NEUROPROTECTIVE AGENTS; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0033429415     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Barinaga M. Finding new drugs to treat stroke. Science 1996;272:664-6.
2. Choi DW. Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 1996;6:667-72.
3. Loscher W, Wlaz P, Szabo L. Focal ischemia enhances the adverse effect potential of N-methyl-D-aspartate receptor antagonists in rats. Neurosci Lett 1998;240:33-6.
4. Chen J, Graham SH, Moroni F, Simon RP. A study of the dose dependency of a glycine receptor antagonist in focal ischemia. J Pharmacol Exp Ther 1993;267:937-41.
5. Warner DS, Martin H, Ludwig P, McAllister A, Keana JF, Weber E. In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor glycine site antagonists. J Cereb Blood Flow Metab 1995;15:188-96.
6. Ilyin VI, Whittemore ER, Tran M, et al. Pharmacology of ACEA-1416: a potent systemically active NMDA receptor glycine site antagonist. Eur J Pharmacol 1996;310:107-14.
7. Takaoka S, Bart RD, Pearlstein R, Brinkhous A, Warner D. Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled. J Cereb Blood Flow Metab 1997;17:161-7.
8. Takano K, Tatlisumak T, Formato JE, et al. Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies. Stroke 1997;28:1255-62.
9. Tatlisumak T, Takano K, Meiler MR. Fisher M. A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Stroke 1998;29:190-5.
10. Dogan A, Rao AM, Baskaya MK, et al. Effects of ifenprodil, a polyamine site NMDA antagonist, on reperfusion injury after transient focal cerebral ischemia. J Neurosurg 1997;87:921-6.
11. DiX, Bullock R, Watson J, et al. Effect of CP101 606, a novel NR2B subunit antagonist of the N-methyl-D-aspartate receptor, on the volume of ischemic brain damage and cytotoxic brain edema after middle cerebral artery occlusion in the feline brain. Stroke 1997;28: 2244-51.
12. Kaufmann WE, Worley PF, Pegg J, Bremer M, Isakson P. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc Natl Acad Sci USA 1996;93:2317-21.
13. Nogawa S, Zhang F, Ross RE, Iadecola C. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 1997;17:2746-55.
14. Collaco-Moraes Y, Aspey B, Harrison M, de Blleroche J. Cyclooxygenase-2 messenger RNA induction in focal cerebral ischemia. J Cereb Blood Flow Metab 1996;16:1366-72.
15. 2. Proc Natl Acad Sci USA 1997;94:6500-5.
16. Nogawa S, Forster C, Zhang F, Nagayama M, Ross ME, Iadecola C. Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia. Proc Natl Acad Sci USA 1998;95: 10966-71.
17. Ohtsuki T, Kitagawa K, Yamagata K, et al. Induction of cyclooxygenase-2 mRNA in gerbil hippocampal neurons after transient forebrain ischemia. Brain Res 1996;736:353-6.
18. Relton JK, Beckey VE, Hanson WL, Whalley ET. CP-0597, a selective bradykinin B2 receptor antagonist, inhibits brain injury in a rat model of reversible middle cerebral artery occlusion. Stroke 1997;28:1430-6.
19. Bruce AJ, Boling W, Kindy MS, et al. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 1996;2:788-94.
20. Zhang RL, Chopp M, Zaloga C, et al. The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat. Brain Res 1995;682:182-8.
21. Lindsberg PJ, Carpen O, Paetau A, Karjalainen-Lindsberg ML, Kaste M. Endothelial ICAM-1 expression associated with inflammatory cell response in human ischemic stroke. Circulation 1996; 94:939-45.
22. Connolly ES Jr, Winfree CJ, Springer TA, et al. Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of leukocyte adhesion in the pathogenesis of stroke. J Clin Invest 1996;97:209-16.
23. Soriano SG, Wang YF, Lipton SA, Dikkes P, Gutierrez-Ramos JC, Hickey PR. ICAM-1 dependent pathway is not involved in the development of neuronal apoptosis after transient focal cerebral ischemia. Brain Res 1998;780:337-41.
24. Clemens JA, Stephenson DT, Smalstig EB, Dixon EP, Little SP. Global ischemia activates nuclear factor-κB in forebarin neurons of rats. Stroke 1997;28:1073-80.
25. Bartus RT, Dean RL, Mennerick S, Eveleth D, Lynch G. Temporal ordering of pathogenic events following transient global ischemia. Brain Res 1998;790:1-13.
26. Hong SC, Lanzino G, Goto Y, et al. Calcium-activated proteolysis in rat neocortex induced by transient focal ischemia. Brain Res 1994;661:43-50.
27. 2+, PIP2 and calpain responses prior to delayed neuronal death in monkeys. Eur J Neurosci 1996;8:1932-44.
28. Hong SC, Goto Y, Lanzino G, Soleau S, Kassell NF, Lee KS. Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia. Stroke 1994;25:663-9.
29. Wang KK, Nath R, Posner A, et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci USA 1996;93:6687-92.
30. Markgarf CG, Velayo NL, Johnson MP, et al. Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats. Stroke 1998;29:152-8.
31. Yuan J, Shaham S, Ledoux S, Ellis HM, Horovitz HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 1993;75:641-52.
32. Kuida K, Zheng TS, Na S, et al. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 1996;384:368-72.
33. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998;94:481-90.
34. Kuida K, Haydar TF, Kuan CY, et al. Reduced apoptosis and cytochrome c mediated caspase activation in mice lacking caspase 9. Cell 1998;94:325-37.
35. Wang S, Miura M, Jung YK, Zhu H, Li E, Yuan J. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 1998;92:501-9.
36. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 1997;90:504-13.
37. Yoshida H, Kong YY, Yoshida R, et al. Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 1998; 94:739-50.
38. Ni B, Wu X, Su Y, et al. Transient global forebrain ischemia induces a prolonged expression of the caspase-3 mRNA in rat hippocampal CA1 pyramidal neurons. J Cereb Blood Flow Metab 1998;18:248-56.
39. Bhat RV, DiRocco R, Marcy VR, et al. Increased expression of IL-1β converting enzyme in hippocampus after ischemia: selective localization in microglia. J Neurosci 1996;16:4416-54.
40. Namura S, Zhu J, Fink K, et al. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J Neurosci 1998;18:3659-68.
41. Asahi M, Hoshimaru M, Uemura Y, et al. Expression of interleukin-1β converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery. J Cereb Blood Flow Metab 1997;17:11-8.
42. Gottron FJ, Ying HS, Choi DW. Caspase inhibition selectively reduces the apoptotic component of oxygen-glucose deprivation-induced cortical neuronal cell death. Mol Cell Neurosci 1997;9: 159-69.
43. Hara H, Friedlander RM, Gagliardini V, et al. Inhibition of interleukin-1β converting enzyme gene family proteases reduces ischemic and excitotoxic neuronal damage. Proc Natl Acad Sci USA 1997;94: 2007-12.
44. Endres M, Namura S, Shimizu-Sasamata M, et al. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J Cereb Blood Flow Metab 1998;18:238-47.
45. Ma J, Endres M, Moskowitz MA. Synergistic effects of caspase inhibitor and MK-801 in brain injury after transient focal cerebral ischemia in mice. Br J Pharmacol 1998;124:756-62.
46. Chen J, Nagayama T, Jin K, et al. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 1998;18:4914-28.
47. Himi T, Ishizaki Y, Murota S. A caspase inhibitor blocks ischemia-induced delayed neuronal death in the gerbil. Eur J Neurosci 1998; 10:777-81.
48. Hara H, Fink K, Endres M, et al. Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein. J Cereb Blood Flow Metab 1997;17:370-5.
49. McCarthy NJ, Whyte MK, Gilbert CS, Even GI. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J Cell Biol 1997;136:215-27.
50. Liu PK, Hsu CY, Dizdaroglu M, et al. Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemiareperfusion. J Neurosci 1996;16:6795-806.
51. Chen J, Jin K, Chen M, et al. Early detection of DNA strand breaks in the brain after transient focal ischemia: implications for the role of DNA damage in apoptosis and neuronal cell death. J Neurochem 1997;69:232-45.
52. Tagaya M, Liu KF, Copeland B, et al. DNA scission after focal brain ischemia. Temporal differences in two species. Stroke 1997;28: 1245-54.
53. Altuvia S, Weinstein-Fischer D, Zhang A, Postow L, Storz G. A small, stable RNA induced by oxidative stress: role as a pleiotropic regulator and antimutator. Cell 1997;90:43-53.
54. 54: Crawford DR, Schools GP, Davies KJ. Oxidant-inducible adapt is RNA is associated with growth arrest - and DNA damage-inducible gadd153 and gadd154. Arch Biochem Biophys 1996;329:137-44.
55. Liu X, Zou H, Slaughter C, Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 1997;89:175-84.
56. Liu X, Li P, Widlak P, et al. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci USA 1998;95:8461-6.
57. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 1998;391:43-50.
58. Darmon AJ, Ley TJ, Nicholson DW, Bleackley RC. Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell fragmentation. J Biol Chem 1996;271: 21709-12.
59. Zhang J, Dawson VL, Dawson TD, Snyder SH. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 1994; 263:687-9.
60. Endres M, Wang ZQ, Namura S, Waeher C, Moskowitz MA. Ischemic brain injury is mediated by the activation of poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab 1997;17:1143-51.
61. Sun AY, Cheng JS. Neuroprotective effects of poly(ADP-ribose) polymerase inhibitors in transient focal cerebral ischmia of rats. Acta Pharmacol Sin 1998;19:104-8.
62. Takahashi K, Greenberg JH, Jackson P, Maclin K, Zhang J. Neuro-protective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats. J Cereb Blood Flow Metab 1997;17: 1137-42.
63. Love S, Barber R, Wilcock GK. Apoptosis and expression of DNA repair proteins in ischemic brain injury in man. Neuroreport 1998; 9:955-9.
64. Lindahl T, Satoh MS, Poirier GG, Klungland A. Post-translational modification of poly (ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem Sci 1995;20:405-11.
65. Eliasson MJ, Sampei K, Mandir AS, et al. Poly(ADP-ribose) polymerase gene disruption renders mice resistance to cerebral ischemia. Nat Med 1997;3:1089-95.
66. Menissier de Murcia J, Niedergang C, Trucco C, et al. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci USA 1997;94:7303-7.