Early caspase activation in leukemic cells subject to etoposide-induced G2-M arrest: Evidence of commitment to apoptosis rather than mitotic cell death

Clinical Cancer Research

Volumn 6, Issue 9, 2000, Pages 3756-3765

  Sleiman, R J ^a   Stewart, B W ^a  

^a South Eastern Sydney and Illawarra Area Health Service   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; ETOPOSIDE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL CYCLE G2 PHASE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CASPASES; CELL DEATH; ENZYME ACTIVATION; ETOPOSIDE; G2 PHASE; HUMANS; LEUKEMIA, T-CELL, ACUTE; MITOSIS; TUMOR CELLS, CULTURED;

EID: 0033817520     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (78)

1. Regulation of the p53 protein by the MDM2 oncoprotein - Thirty-eighth G. H. A. Clowes Memorial Award Lecture
2. A fundamental role for cell cycle regulation in the chemosensitivity of cancer cell?
3. p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents
4. DNA topoisomerases: Essential enzymes and lethal targets
5. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
6. Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways
7. Caspases: The executioners of apoptosis
8. Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase
9. The apoptotic cysteine protease CPP32
10. Life, death and genomic change in perturbed cell cycles
11. pRb and the Cdks in apoptosis and the cell cycle
12. 2 phase and cell death induced by cisplatin
13. The role of apoptosis in cell killing by cisplatin: A flow cytometric study
14. The role of cell cycle progression in cisplatin-induced apoptosis in Chinese hamster ovary cells
15. Delayed reproductive death in X-irradiated Chinese hamster ovary cells
16. 2 to M transition: Implications for gene therapy
17. Apoptosis of L929 cells by etoposide: A quantitative and kinetic approach
18. Possible role for p34(cdc2) kinase in etoposide-induced cell death of Chinese hamster ovary cells
19. The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification. DNA digestion and apoptosis
20. 2 arrest induced by nitrogen mustard
21. 2 phase cell cycle checkpoint blocks cdc25-dependent progression into mitosis
22. Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis
23. 1 arrest and apoptosis
24. Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival
25. 2/M transition after DNA damage: A mechanism of resistance to multiple anticancer agents
26. Induction of apoptosis by 5-aracytidine: Drug concentration-dependent differences in cell cycle specificity
27. Involvement of the Fanconi's anemia protein FAC in a pathway that signals to the cyclin B/cdc2 kinase
28. Concentration-dependent differences in the mechanisms by which caffeine potentiates etoposide cytotoxicity in HeLa cells
29. 2-check-point inhibitor
30. 2 delay potentiates cell death by apoptosis and/or induction of giant cells in colorectal tumor cells with disrupted p53 function
31. p53-Induced apoptosis in the human T-ALL cell line CCRF-CEM
32. Alternative splicing of the p53 tumor suppressor gene in the Molt-4 T-lymphoblastic leukaemia cell line
33. Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines
34. 2/M arrest: Higher order DNA fragmentation as an indicator of mechanism
35. Apoptosis without caspases: An inefficient molecular guillotine?
36. Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells
37. The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate Lamin A
38. Anonymous Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly(ADP-ribose) polymerase and restores the NF-kB signaling pathway
39. Lamin proteolysis facilitates nuclear events during apoptosis
40. Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells
41. Immunohistochemical analysis of in vivo patterns of expression of CPP32 (caspase-3), a cell death protease
42. 1 expression in human melanoma cells
43. 2 delay in HeLa cells
44. 2 arrest following DNA damage
45. 2 checkpoint
46. Overexpression of Bcl-2 or Bcl-x(L) inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells
47. Activation of multiple interleukin-1b converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis
48. Caspases. Intracellular signaling by proteolysis
49. Role of proteolysis in apoptosis: Involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes
50. Etoposide-induced cytotoxicity in two human T-cell leukemic lines: Delayed loss of membrane permeability rather than DNA fragmentat on as an indicator of programmed cell death
51. Apoptosis and the cell cycle: The p53 connection
52. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death
53. 2 arrest in mammalian cells
54. Chemically induced premature mitosis: Differential response in rodent and human cells and the relationship to cyclin B synthesis and p34(cdc2)/cyclin B complex formation
55. Apoptosis and cancer chemotherapy
56. Intracellular acidification induces apoptosis by stimulating ICE-like protease activity
57. Intact cell evidence for the early synthesis, and subsequent late apopain-mediated suppression, of poly(ADP-ribose) during apoptosis
58. 2 phase checkpoints
59. Selective radiosensitisation of p53 deficient cells by caffeine-mediated activation of p34(cdc2) kinase
60. The caspase-RB connection in cell death
61. Dysregulation of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1/MDA6) increases the susceptibility of human leukemia cells (U937) to 1-β-D-arabinofuranosylcytosine-mediated mitochondrial dysfunction and apoptosis
62. Requirement of p34(cdc2) kinase for apoptosis in mediated by the Fas/APO-1 receptor and interleukin 1β-converting enzyme-related proteases
63. Mechanism of potentiation by caffeine of genotoxic damage induced by physical and chemical agents
64. 2 block induced by DNA damage: A caffeine-resistant component independent of Cdc25C, MPM-2 phosphorylation, and H1 kinase activity
65. 2 delay
66. 1 checkpoint-competent cells
67. p53-Null cells are more sensitive to ultraviolet light only in the presence of caffeine
68. 2/M cell cycle arrest and apoptosis in p53-deficient lymphoblastic leukemia cells without affecting Bcl-2 and Bax expression
69. Enhancement of CDDP cytotoxicity by caffeine is characterised by apoptotic cell death
70. 2 delay causes HeLa cells to undergo apoptosis instead of mitotic death
71. Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells
72. Caffeine modulates heat shock induced apoptosis in the human promyelocytic leukaemia cell line HL-60
73. Expression of apoptosis-related oncoproteins and modulation of apoptosis by caffeine in human leukemic cells
74. Apoptosis, p53 and tumor cell sensitivity to anticancer agents
75. Apoptosis and chemotherapy resistance
76. Camptothecin, teniposide, or 4'-(9-acridinylamino)-3-methanesulfon-m-anisidine, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells
77. Treatment of childhood leukaemia