Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat

Gut

Volumn 48, Issue 4, 2001, Pages 478-488

  Cuzzocrea, S ^a   McDonald, M C ^b   Mazzon, E ^a   Mota Filipe, H ^b   Centorrino, T ^c   Terranova, M L ^c   Ciccolo, A ^c   Britti, D ^c   Caputi, A P ^a   Thiemermann, C ^b  

^a UNIVERSITY OF MESSINA   (Italy)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

Calpain; Calpain inhibitor I; Cyclooxygenase; Inflammatory bowel disease; Nitric oxide; Rat

Indexed keywords

3 NITROTYROSINE; CALPASTATIN; CALPASTATIN 1; DINITROBENZENESULFONIC ACID; INTERCELLULAR ADHESION MOLECULE 1; MALONALDEHYDE; MYELOPEROXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE SYNTHASE; NITROBENZENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; COLON INJURY; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ADENOSINE DIPHOSPHATE RIBOSE; ANALYSIS OF VARIANCE; ANIMALS; CYSTEINE PROTEINASE INHIBITORS; DINITROBENZENES; GLYCOPROTEINS; INFLAMMATORY BOWEL DISEASES; INTERCELLULAR ADHESION MOLECULE-1; MALE; MALONDIALDEHYDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; P-SELECTIN; PEROXIDASE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; SULFONIC ACIDS; TYROSINE; UP-REGULATION;

EID: 0035082019     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.48.4.478     Document Type: Article

References (90)

1. The calpains
2. Calpain: New perspectives in molecular diversity and physiologicalpathophysiological involvement
3. Calpain inhibition: An overview of its therapeutic potential
4. Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor
5. Mutual regulation of the transcription activator NF-kappa Band its inhibitor, I kappa B
6. Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB
7. Structure, regulation and function of NF-kappa B
8. Inhibitors of proteosome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B
9. Analysis of the signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages
10. Inhibition of IkappaB-alpha and Ikappa-B-beta proteolysis by calpain inhibitor I blocks nitric oxide synthase synthesis
11. Transcriptional roles of nuclear factor kappa B and nuclear factorinterleukin-6 in the tumor necrosis factor-alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells
12. Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes
13. Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease
14. Oxidants and free radicals in inflammatory bowel disease
15. Peroxynitrite-induced rat colitis - A new model of colon inflammation
16. Increased nitric oxide synthesis in ulcerative colitis
17. Nitric oxide synthase activity in ulcerative colitis and Crohn's disease
18. Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis
19. Nitric oxide in the gut
20. Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation
21. Nitric oxide: Physiology, pathophysiology and pharmacology
22. Nitric oxide as a secretory product of mammalian cells
23. Greatly increased luminal nitric oxide in ulcerative colitis
24. Distribution of inducible nitric oxide synthase in ulcerative colitis
25. Spontaneous intestinal inflammation and nitric oxide metabolism in HLA-B27 transgenic rats
26. Potential role of nitric oxide in a model of chronic colitis in rhesus maeaques
27. Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis
28. Toxic dilatation of colon in a rat model of colitis is linked to an inducible form of nitric oxide synthase
29. Sulhydryl blocker-induced rat colon inflammation is ameliorated by inhibition of nitric oxide synthase
30. Apparent hydroxyl radical production by peroxynitrite: Implication for endothelial injury from nitric oxide and superoxide
31. The role of peroxynitrite in the pathophysiology of shock, inflammation and ischemia-reperfusion injury
32. The role of peroxynitrite in nitric oxide-mediated toxicity
33. TNF-alpha induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C
34. Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide
35. DNA damage and oxidation of thiols peroxynitrite causes in rat thymocytes
36. Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide
37. Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer
38. Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease
39. Inhibition of poly (ADP-ribose) synthetase exerts antiinflammatory effects and inhibits neutrophil recruitment
40. Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-ribose) synthetase
41. Peroxynitrite-mediated DNA strand breakage activates poly (ADP-ribose) synthetase and causes cellular energy depletion in carrageenan-induced pleurisy
42. Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in carrageenan-induced models of local inflammation
43. Blockade of poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis
44. Inhibition of poly (ADP-ribose) synthetase protects against myocardial ischemia and reperfusion injury
45. Inhibition of the activity of poly(ADP-ribose) synthase reduces ischemia-reperfusion injury in the heart and skeletal muscle
46. Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion
47. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
48. Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase
49. Calpain as a novel target for treating acute neurodegenerative disorders
50. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective
51. Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats
52. Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis
53. Role of calcium-activated neutral protease (calpain) in cell death in cultured neonatal rat cardiomyocytes during metabolic inhibition
54. Reperfusion of rat heart after brief ischemia induces proteolysis of calspectin by calpain
55. Calpain activity alteres rat myocardial subfractions after ischemia and reperfusion
56. Calpain inhibitor I reduces infarct size and DNA fragmentation of myocardium in ischemic/reperfused hearts
57. Exacerbation of experimental colitis by non-steroidal antinflammatory drugs is not related to elevated leukotriene B4 synthesis
58. Hapten-induced model of chronic inflammation and ulceration in the rat
59. Effects of zileuton, a new 5-lipoxygenase inhibitor, in experimentally induced colitis in rats
60. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium
61. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
62. Nitric oxide-mediated hyporeactivity to norepinephrine precedes the induction of nitric oxide synthase in endotoxin shock
63. Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells
64. Active oxygen species generated by monocytes and polymorphonuclear cells in patients in Crohn's disease
65. Oxygen-derived free radical generating capacity of polymorphonuclear cells in patients with ulcerative colitis
66. Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colon damage in rats
67. Role of transcription factor NF-B/Rel in induction of nitric oxide
68. Serine and cysteine proteinase inhibitors prevent nitric oxide production by activated macrophages by interfering with transcription of inducible NO synthase gene
69. Effect of calpain inhibitor I, an inhibitor of the proteolysis of I kappa B, on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat
70. Proteolytic processing of nuclear factor kappa B by calpain in vitro
71. Oxidative damage and tyrosine nitration from peroxynitrite
72. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
73. Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors
74. Relationship between nitric oxide and prostaglandins in carrageenin pleurisy
75. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase
76. 2 formation in rat carrageenin-induced pleurisy
77. Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation
78. Reperfusion of rat heart after brief ischemia induces proteolysis of calspectin by calpain
79. Downregulation of calpastatin in rat heart after brief brain ischemia and reperfusion
80. Mechanisms of calpain proteolysis following traumatic brain injury: Implications for pathology and therapy: A review and update
81. Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo
82. Calpain as a novel target for treating acute neurodegenerative disorders
83. An alphamercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective
84. Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats
85. Calpain is a mediator of preservation-reperfusion injury in rat liver transplantation
86. Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis
87. Calcium-activated neutral protease inhibitor (E-64c) and reperfusion from experimental myocardial infarction
88. Role of calcium-activated neutral protease (calpain) in cell death in cultured neonatal rat cardiomyocytes during metabolic inhibition
89. Calpain activity alters rat myocardial subfractions after ischemia and reperfusion
90. Protective effect of the protease inhibitor leupeptin against myocardial stunning