Regulated protein degradation in mitochondria

Experientia

Volumn 52, Issue 12, 1996, Pages 1069-1076

  Langer, T ^a   Neupert, W ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

AAA protease; Chaperone; Mitochondria; PIM1 protease; Proteolysis

Indexed keywords

ADENOSINE TRIPHOSPHATE; HEAT SHOCK PROTEIN 70; METALLOPROTEINASE; MITOCHONDRIAL DNA; MITOCHONDRIAL ENZYME; POLYPEPTIDE; PROTEINASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

BIOGENESIS; ESCHERICHIA COLI; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN FOLDING; REGULATORY MECHANISM; REVIEW; SEQUENCE HOMOLOGY;

ADENOSINE TRIPHOSPHATE; ENDOPEPTIDASES; HSP70 HEAT-SHOCK PROTEINS; MEMBRANE PROTEINS; MITOCHONDRIA; MODELS, BIOLOGICAL; PROTEINS; SERINE ENDOPEPTIDASES;

EID: 0030475162     PISSN: 00144754     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01952104     Document Type: Review

References (63)

1. Goldberg A. L. and Rock K. L. (1992) Proteolysis. proteasomes and antigen presentation. Nature 357: 375-379
2. Gottesman S. and Maurizi M. R. (1992) Regulation by proteolysis: energy-dependent proteases and their targets. Microbiol. Rev. 56: 592-621
3. Takeshige K., Baba M., Tsuboi S., Noda T. and Ohsumi Y. (1992) Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for induction. J. Cell Biol. 119: 301-311
4. Walker J. H., Burgess R. L. and Mayer R. J. (1978) Relative rate of turnover of subunits of mitochondrial proteins. Biochem. J. 176: 927-932
5. Russel S. M., Burgess R. J. and Mayer R. J. (1980) Protein degradation in rat liver during post-natal development. Biochem. J. 192: 321-330
6. 14C] bicarbonate incorporation. J. Biol. Chem. 256: 8652-8657
7. Dice J. K. and Goldberg A. L. (1975) Relationship between in vivo degradative rates and isoelectric points of proteins. Proc. Natl. Acad. Sci. USA 72: 3893-3897
8. Desautels M. and Goldberg A. L. (1982) Demonstration of an ATP-dependent. vanadate-sensitive endoprotease in the matrix of rat liver mitochondria. J. Biol. Chem. 257: 11673-11679
9. Desautels M. and Goldberg A. L. (1982) Liver mitochondria contain an ATP-dependent, vanadate-sensitive pathway for the degradation of proteins. Proc. Natl. Acad. Sci. USA 79: 1869-1873
10. Watabe S. and Kimura T. (1985) Adrenal cortex mitochondrial enzyme with ATP-dependent protease and protein-dependent ATPase activities. J. Biol. Chem. 260: 14498-14504
11. Watabe S. and Kimura T. (1985) ATP-dependent protease in bovine adrenal cortex. J. Biol. Chem. 260: 5511-5517
12. Kutejová E., Durcová G., Surovková E., and Kuzela S. (1993) Yeast mitochondrial ATP-dependent protease: purification and comparison with the homologous rat enzyme and the bacterial ATP-dependent protease La. FEBS Lett. 329: 47-50
13. Wang N., Gottesman S., Willingham M. C. Gottesman M. M. and Maurizi M. R. (1993) A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease. Proc. Natl. Acad. Sci. USA 90: 11247-11251
14. Van Dyck L., Pearce D. A. and Sherman F. (1994) PIM1 encodes a mitochondrial ATP-dependent protease that is required for mitochondrial function in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 269: 238-242
15. Suzuki C. K., Suda K., Wang N. and Schatz. G. (1994) Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration. Science 264: 273-276
16. Teichmann U., van Dyck L., Guiard B., Fischer H., Glockshuber R., Neupert W. et al. (1996) Substitution of PIM1 protease in mitochondria by Escherichia coli ton protease, J. Biol. Chem. 271: 10137-10142
17. Wagner I., Arlt H., van Dyck L., Langer T. and Neupert W. (1994) Molecular chaperones cooperate with PIM1 protease in the degradation of misfolded proteins in mitochondria. EMBO J. 13: 5135-5145
18. Rowley N., Prip B. C., Westermann B., Brown C., Schwarz E., Barrell B. et al. (1994) Mdj1p. a novel chaperone of the DnaJ family, is involved in mitochondrial biogenesis and protein folding. Cell 77: 249-259
19. Bolliger L., Deloche O., Glick B. S., Georgopoulos C., Jeno P., Kronidou N. et al. (1994) A mitochondrial homolog of bacterial GrpE interacts with mitochondrial hsp70 and is essential for viability. EMBO J. 13: 1998-2006
20. Laloraya S., Dekker P. J. T., Voos W., Craig E. A. and Pfanner N. (1995) Mitochondrial GrpF. modulates the function of matrix Hsp70 in translocation and maturation of preproteins. Mol. Cell. Biol. 15: 7098-7105
21. Westermann B., Prip-Buus C., Neupert W. and Schwarz E. (1995) The role of the GrpE homologue. Mge1p. in mediating protein import and protein folding in mitochondria. EMBO J. 14: 3452-3460
22. Prip-Buus C., Westermann B., Schmitt M., Langer T., Neupert W. and Schwarz E. (1996) Role of the mitochondrial DnaJ homologue. Mdj1p, in the prevention of heat-induced protein aggregation. FEBS Lett. 380: 142-146
23. Ikeda E., Yoshida S., Mitsuzawa H., Uno I. and Toh-e. A. (1994) YGE1 is a yeast homolog of Escherichia coli grpE and is required for maintenance of mitochondrial functions. FEBS Lett. 339: 265-268
24. Stuart R. A., Cyr D. M., Craig E. A. and Neupert W. (1994) Mitochondrial molecular chaperones: their role in protein translocation. Trends Biochem. Sci. 19: 87-92
25. Langer T. and Neupert W. (1994) Chaperoning mitochondrial biogenesis. In: The Biology of Heat Shock Proteins and Molecular Chaperones. pp. 53-83, Morimoto R., Tissières A. and Georgopoulos C. (eds). Cold Spring Harbor Laboratory Press, Cold Spring Harbor
26. Sherman M. and Goldberg A. L. (1992) Involvement of the chaperonin dnaK in the rapid degradation of a mutant protein in Escherichia coli. EMBO J. 11: 71-77
27. Schmitt M., Neupert W. and Langer T. (1995) Hsp78. a Clp homologue within mitochondria, can substitute for chaperone functions of mt-hsp70. EMBO J. 14: 3434-3444
28. Horwich A. L. (1995) Resurrection or destruction? Curr. Biol. 5: 455-458
29. Kessel M., Maurizi M. R., Kim B., Kocsis E., Trus B. L., Singh S. K. et al. (1995) Homology in structural organization between E. coli ClpAP protease and the eukaryotic 26 S proteasome. J. Mol. Biol. 250: 587-594
30. Gottesman S., Clark W. P., de Crecy-Lagard V. and Maurizi M. R. (1993) ClpX, an alternative subunit for the ATP-dependent Clp protease of Escherichia coli: sequence and in vivo activities. J. Biol. Chem. 268: 22618-22626
31. Wojtkowiak D., Georgopoulos C. and Zylicz M. (1993) Isolation and characterization of ClpX. a new ATP-dependent specificity component of the Clp protease of Escherichia coli. J. Biol. Chem. 268: 22609-22617
32. Wickner S., Gottesman S., Skowyra D. Hoskins J., McKenney K and Maurizi M. R. (1994) A molecular chaperone. ClpA. functions like DnaK and DnaJ. Proc. Natl. Acad. Sci. USA 91: 12218-12222
33. Wawrzynow A., Wojtkowiak D., Marszalek J., Banecki B., Jonsen M., Graves B. et al. (1995) The ClpX heat-shock protein of Escherichia coli. the ATP-dependent substrate specificity component of the ClpP-ClpX protease. is a novel molecular chaperone. EMBO J. 14: 1867-1877
34. Bross P., Andresen B. S., Knudsen I., Kruse T. A. and Gregersen. N. (1995) Human ClpP protease: cDNA sequence, tissue-specific expression and chromosomal assignment of the gene. FEBS Lett. 377: 249-252
35. Leonhardt S. A., Fearon K., Danese P. N. and Mason T. L. (1993) Hsp78 encodes a yeast mitochondrial heat shock protein in the Clp family of ATP-dependent proteases. Mol. Cell. Biol. 13: 6304-6313.
36. 35a Schmitt M., Neupert W. and Langer T. (1996) The molecular chaperone Hsp78 confers compartment-specific thermotolerance to mitochondria. J. Cell Biol. 134: 1375-1386
37. Wheeldon L. W., Dianoux A. C. Bof M. and Vignais P. V. (1974) Stable and labile products of mitochondrial protein synthesis in vitro. Kur. J. Biochem. 46: 189-199
38. Kalnov S. L., Novikova L. A., Zubatov A. S. and Luzikov V. N. (1979) Proteolysis of the products of mitochondrial protein synthesis in yeast mitochondria and submitochondrial particles. Biochem. J. 182: 195-202
39. Tzagoloff A. and Myers A. M. (1986) Genetics of mitochondrial biogenesis. Annu. Rev. Biochem. 55: 249-285
40. m39 Grivell L. A. (1989) Nucleo-mitochondrial interactions in yeast mitochondrial biogenesis. Eur. J. Biochem. 182: 477-493
41. m40 Yasuhara T., Mera Y., Nakai T., and Onashi A. (1994) ATP-dependent proteolysis in yeast mitochondria. J. Biochem. 115: 1166-1171
42. Pajic A., Tauer R., Feldmann H., Neupert W., and Langer T. (1994) Yta10p is required for the ATP-dependent degradation of polypeptides in the inner membrane of mitochondria. FEBS Lett. 353: 201-206
43. Thorsness P. E., While K. H. and Fox T. D. (1993) Inactivation of YME1, a member of the ftsH-SEC18 PAS1 CDC48 family of putative ATPase-encoding genes, causes increased escape of DNA from mitochondria in Saccharomyces cerevisiae. Mol. Cell. Biol. 13: 5418-5426
44. m43 Guélin E., Rep M. and Grivell L. A. (1994) Sequence of the AFG3 gene encoding a new member of the FtsH Ymel Tma subfamily of the AAA-protein family. Yeast 10: 1389-1394
45. m44 Tauer R., Mannhaupt G., Schnall R., Pajic A., Langer T. and Feldmann H. (1994) Yta10p. a member of a novel ATPase family in yeast, is essential for mitochondrial function. FEBS Lett. 353: 197-200
46. m45 Tzagoloff A . Yue J., Jang J. and Paul M. F. (1994) A new member of a family of ATPases is essential for assembly of mitochondrial respiratory chain and ATP synthetase complexes in Saccharomyces cerevisiae. J. Biol. Chem. 269: 26144-26151
47. Kunau W. H., Beyer A., Franken T., Gotte K., Marzioch M., Saidowsky J. et al. (1993) Two complementary approaches to study peroxisome biogenesis in Saccharomyces cerevisiae: forward and reversed genetics. Biochimie 75: 209-224
48. m47 Confalonieri F. and Duguet M. (1995) A 200-amino acid ATPase module in search of a basic function. BioEssays 17: 639-650
49. m48 Rawlings N. D. and Barrett A. J. (1993) Evolutionary families of peptidases. Biochem. J. 290: 205-218
50. m49 Stocker W. and Bode W. (1995) Structural features of a superfamily of zinc-endopeptidases: the metzincins. Curr. Op. Struct Biol. 5: 383-390.
51. m50 Arlt H., Tauer R., Feldmann H., Neupert W. and Langer T. (1996) The YTA10 12-complex. an AAA protease with chaperone-like activity in the inner membrane of mitochondria. Cell 85: 875-885
52. Guélin E., Rep M. and Grivell L. A. (1996) Afg3p. a mitochondrial ATP-dependent metalloprotease, is involved in the degradation of mitochondrially-cncoded Cox1, Cox3, Cob, Su6, Su8 and Su9 subunits of the inner membrane complexes III, IV and V. FFBS Lett. 381: 42-46
53. Leonhard K., Herrmann J. M., Stuart R. A., Mannhaupt G., Neupert W. and Langer T. (1996) AAA proteases with catalytic sites on opposite membrane surfaces comprise a proteolytic system for the ATP-dependent degradation of inner membrane proteins in mitochondria. EMBO J. 15: 4218-4229
54. 1ATPase assembly in Saccharomyces cerevisiae. FEBS Lett. 373: 66-70
55. Schnall R., Mannhaupt G., Stucka R., Tauer R., Ehnle S., Schwarzlose C. et al. (1994) Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex. Yeast 10: 1141-1155
56. m55 Nakai T., Yasuhara T., Fujiki Y. and Ohashi A. (1995) Multiple genes, including a member of the AAA family, are essential for degradation of unassembled subunit 2 of cytochrome c oxidase in yeast mitochondria. Mol. Cell. Biol. 15: 4441-4452
57. m56 Nakai T., Mera Y., Yasuhara T. and Ohashi A. (1994) Divalent metal ion-dependent mitochondrial degradation of unassembled subunits 2 and 3 of cytochrome c oxidase. J. Biochem. 116: 752-758
58. m57 Pearce D. A. and Sherman F. (1995) Degradation of cytochrome oxidase subunits in mutants of yeast lacking cytochrome c and suppression of the degradation by mutation of yme1. J. Biol. Chem. 270: 1-4
59. Weber E. R., Hanekamp T. and Thorsness P. E. (1996) Biochemical and functional analysis of the YME1 gene product, an ATP and zinc-dependent mitochondrial protease from S. cerevisiae. Mol, Biol. Cell 7: 307-317.
60. m59 Campbell C. L , Tanaka N., White K. H. and Thorsness, P. E. (1994) Mitochondrial morphological and functional defects in yeast caused by yme 1 are suppressed by mutation of a 26S protease subunit homologue. Mol. Biol. Cell. 5: 899-905
61. Thorsness P. E. and Fox T. D. (1993) Nuclear mutations in Saccharomyces cerevisiae that affect the escape of DNA from mitochondria to the nucleus. Genetics 134: 21-28
62. Weber E. R., Rooks R. S., Shafer K. S., Chase J. W. and Thorsness P. E. (1995) Mutations in the mitochondrial ATP synthase gamma subunit suppress a slow-growth phenotype of yme 1 yeast lacking mitochondrial DNA. Genetics 140: 435-442
63. Hanekamp T. and Thorsness P. E. (1996) Inactivation of YME2/RNA12. which encodes an integral inner mitochondrial membrane protein, causes increased escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae. Mol. Cell. Biol. 16: 2764-2771