Signaling by the Mpl receptor involves IKK and NF-κB

Journal of Cellular Biochemistry

Volumn 85, Issue 3, 2002, Pages 523-535

  Zhang, Ying ^a   Sun, Shishinn ^a   Wang, Zhengyu ^a   Thompson, Alexander ^a   Kaluzhny, Yulia ^a   Zimmet, Jeffrey ^a   Ravid, Katya ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

IKK; Megakaryocyte; Mpl receptor; NF B

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; THROMBOPOIETIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MITOSIS RATE; NONHUMAN; POLYPLOIDY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STEM CELL; THROMBOCYTE;

ANIMALS; APOPTOSIS; BONE MARROW CELLS; CELL DIVISION; CELLS, CULTURED; DIMERIZATION; DNA; DOWN-REGULATION; I-KAPPA B KINASE; MEGAKARYOCYTES; MICE; NEOPLASM PROTEINS; NF-KAPPA B; POLYPLOIDY; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RATS; RECEPTORS, CYTOKINE; RECEPTORS, THROMBOPOIETIN; SIGNAL TRANSDUCTION; THROMBOPOIETIN; TRANS-ACTIVATION (GENETICS);

EID: 0036242153     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10141     Document Type: Article

References (73)

1. In vivo regulation of interleukin-2 receptor alpha gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cells
2. IκB: A specific inhibitor of the NF-κB transcription factor
3. Function and activation of NF-κB in the immune system
4. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: A mechanism for NF-kappa B activation
5. Expression of a constitutive NF-kappa B-like activity is essential for proliferation of cultured bovine vascular smooth muscle cells
6. Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopietic progenitor cells in vitro
7. The natural product hymenialdisine inhibits interlleukin-8 production in U937 cells by inhibition of nuclear factor-kappa B
8. lck is required for triggering NF-kappa B activation upon interaction of human immunodeficiency virus type 1 envelope glycoprotein gp120 with cell surface CD4
9. Control of IκBα proteolysis by site-specific, signal induced phosphorylation
10. TRAF6 is a signal transducer for interleukin-1
11. Signal-induced site-specific phosphorylation targets IκlB to the ubiquitin-proteosome pathway
12. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity
13. IKAP is a scaffold protein of the IkappaB kinase complex
14. Positive and negative regulation of Iκb Kinase activity through IKKB subunit phosphorylation
15. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
16. Gene expression during phorbal ester-induced differentiation of cultured human megakaryoblastic cells
17. Interaction of an NF-kappa-B-like factor with a site upstream of the c-myc promoter
18. Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors
19. Nuclear factor-kappaB-dependent regulation of p53 gene expression induced by daunomycin genotoxic drug
20. Rapid proteolysis of IκBα is necessary in the activation of transcription factor NF-κB
21. Protein kinase C mediates the mitogenic action of thrombopoietin in c-Mpl-expressing UT-7 cells
22. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
23. Abnormal morphogenesis but intact IKK activity in mice lacking the IKKa subunit of IkB kinase
24. Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha
25. Biological and biochemical characteristics of murine megakaryoblastic cell line L8057
26. In vivo effects of pegylated recombinant human megakaryocyte growth and development factor on hematopoiesis in normal mice
27. Thrombopoietin: The primary regulator of platelet production
28. Differential regulation of the c-myc oncogene promoter by the NF-kappa B rel family of transcription factors
29. Vascular Smooth Muscle Cells Express a Constitutive NF-κB-like Activity
30. MEKK1 activates both Ikappa B kinase alpha and IkappaB kinase beta
31. Inhibitors of both nuclear factor kappa B and activator protein-1 activation block the neoplastic transformation response
32. Severe liver degeneration in mice lacking the Ikappa B kinase 2 gene
33. Human T-cell lymphotropic virus type 1 Tax1 activation of NF-kappa B: Involvement of the protein kinase C pathway
34. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of ser-176
35. Dissection of TNF receptor 1 effector function: JNK activation is not linked to apoptosis while NF-kappa B activation prevents cell death
36. MAP3K-related kinase involved in NF-kappa B induction by TNF, CD95 and IL-1
37. Catalysis by a multiprotein IkappaB kinase complex
38. Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites
39. Involvement of prolonged ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell line
40. IKK-1 and IKK-2: Cytokine-activated IκB kinase essential for NF-κB activation
41. Differential regulation of Ikappa B kinase alpha and beta by two upstream kinases, NF-kappaB -inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
42. Coordinate regulation of IkappaB kinases by mitogen- activated protein kinase kinase kinase 1 and NF-kappa B-inducing kinase
43. Preclinical biology of megakaryocyte growth and development factor: A summary
44. Jak2 is essential for signaling through a variety of cytokine receptors
45. PTEN-coupling tumor suppression to stem cells?
46. An essential role for NF-kB in human CD34+ bone marrow cell survival
47. Mpl ligand (MGDF) alone and in combination with stem cell factor (SCF) promotes proliferation and survival of human megakaryocyte, erythroid and granulocyte/macrophage progenitors
48. Transcriptional regulation of the rat platelet factor 4 gene: Interaction between an enhancer/silencer domain and the GATA site
49. Identification and characterization of an IκB kinase
50. In vivo control of NF-κB activation by IκBa
51. Transforming-growth-factor-beta activation elements in the distal promoter regions of the rat alpha 1 type I collagen gene
52. The role of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes
53. TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
54. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
55. Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway
56. TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducting kinase-independent mechanism
57. Multiple nuclear factors interact with the immunoglobilin enhancer sequences
58. Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways
59. Limb and skin abnormalities in mice lacking IKKa
60. Deregulated expression of c-myc in megakaryocytes of transgenic mice increases megakaryopoiesis and decreases polyploidization
61. Phosphorylation of human IkB on serine 32 and 36 controls IkB proteolysis and NF-κB activation in response to diverse stimuli
62. Cyclin D3 is essential for megakaryocytopoiesis
63. NF-kappa B antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
64. Mpl ligand enhances the transcription of the cylin D3 gene: A potential role for Sp1 transcription factor
65. The NF-kappaB binding site is essential for transcriptional activation of the IL-15 gene
66. IkB kinase-β activation and complex formation with IkB kinase-α and NIK
67. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappa B activation
68. Thrombopoietin alone stimulates the early proliferation and survival of human erythroid, myeloid and multipotential progenitors in serum-free culture
69. Induction ofinterleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappa B
70. The Iκ B kinase complex (IKK) contains twi kinase subunits, IKKα and IKKβ necessary for IκB phosphorylation and NF-κB activation
71. In vitro senescence and apoptotic cell death of human megakaryocytes
72. Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers
73. Ubiquitin-dependent degradation of cyclin B is accelerated in polyploid megakaryocytes