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Volumn 91, Issue 3, 1998, Pages 813-822

Protein kinase C mediates the mitogenic action of thrombopoietin in c- Mpl-expressing UT-7 cells

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; GLYCOPROTEIN IIB; PHORBOL DIBUTYRATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT THROMBOPOIETIN;

EID: 2642709176     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.3.813     Document Type: Article
Times cited : (38)

References (60)
  • 1
    • 0029035985 scopus 로고
    • Thrombopoietin: The primary regulator of platelet production
    • Kaushansky K: Thrombopoietin: The primary regulator of platelet production. Blood 86:419, 1995
    • (1995) Blood , vol.86 , pp. 419
    • Kaushansky, K.1
  • 2
    • 0031052063 scopus 로고    scopus 로고
    • Thrombopoietin: The primary regulator of megakaryocytopoiesis and thrombopoiesis
    • Eaton DL, de Sauvage FJ: Thrombopoietin: The primary regulator of megakaryocytopoiesis and thrombopoiesis. Exp Hematol 25:1, 1997
    • (1997) Exp Hematol , vol.25 , pp. 1
    • Eaton, D.L.1    De Sauvage, F.J.2
  • 5
    • 0029037953 scopus 로고
    • The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors
    • Debili N, Wendling F, Katz A, Guichard J, Breton Gorius J, Hunt P, Vainchenker W: The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 86:2516, 1995
    • (1995) Blood , vol.86 , pp. 2516
    • Debili, N.1    Wendling, F.2    Katz, A.3    Guichard, J.4    Breton Gorius, J.5    Hunt, P.6    Vainchenker, W.7
  • 9
    • 0029027918 scopus 로고
    • Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors
    • Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M: Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors. Blood 86:2494, 1995
    • (1995) Blood , vol.86 , pp. 2494
    • Kobayashi, M.1    Laver, J.H.2    Kato, T.3    Miyazaki, H.4    Ogawa, M.5
  • 11
    • 0029960265 scopus 로고    scopus 로고
    • Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl
    • Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D: Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood 87:2162, 1996
    • (1996) Blood , vol.87 , pp. 2162
    • Alexander, W.S.1    Roberts, A.W.2    Nicola, N.A.3    Li, R.4    Metcalf, D.5
  • 12
    • 0030039567 scopus 로고    scopus 로고
    • Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice
    • Ku H, Yonemura Y, Kaushansky K, Ogawa M: Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 87:4544, 1996
    • (1996) Blood , vol.87 , pp. 4544
    • Ku, H.1    Yonemura, Y.2    Kaushansky, K.3    Ogawa, M.4
  • 14
    • 0029858989 scopus 로고    scopus 로고
    • Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro
    • Borge OJ, Ramsfjell V, Veiby OP, Murphy MJ Jr, Lok S, Jacobsen SE: Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro. Blood 88:2859, 1996
    • (1996) Blood , vol.88 , pp. 2859
    • Borge, O.J.1    Ramsfjell, V.2    Veiby, O.P.3    Murphy Jr., M.J.4    Lok, S.5    Jacobsen, S.E.6
  • 15
    • 0029894091 scopus 로고    scopus 로고
    • Thrombopoietin suppresses apoptosis and behaves as a survival factor for the human growth factor-dependent cell line, M07e
    • Ritchie A, Vadhan Raj S, Broxmeyer HE: Thrombopoietin suppresses apoptosis and behaves as a survival factor for the human growth factor-dependent cell line, M07e. Stem Cells 14:330, 1996
    • (1996) Stem Cells , vol.14 , pp. 330
    • Ritchie, A.1    Vadhan Raj, S.2    Broxmeyer, H.E.3
  • 16
    • 0025674093 scopus 로고
    • A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors
    • Souyri M, Vigon I, Penciolelli JF, Heard JM, Tambourin P, Wendling F: A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63:1137, 1990
    • (1990) Cell , vol.63 , pp. 1137
    • Souyri, M.1    Vigon, I.2    Penciolelli, J.F.3    Heard, J.M.4    Tambourin, P.5    Wendling, F.6
  • 17
    • 0027245081 scopus 로고
    • Murine c-mpl: A member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal
    • Skoda RC, Seldin DC, Chiang MK, Peichel CL, Vogt TF, Leder P: Murine c-mpl: A member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J 12:2645, 1993
    • (1993) EMBO J , vol.12 , pp. 2645
    • Skoda, R.C.1    Seldin, D.C.2    Chiang, M.K.3    Peichel, C.L.4    Vogt, T.F.5    Leder, P.6
  • 19
    • 0028910991 scopus 로고
    • The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl
    • Drachman JG, Griffin JD, Kaushansky K: The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J Biol Chem 270:4979, 1995
    • (1995) J Biol Chem , vol.270 , pp. 4979
    • Drachman, J.G.1    Griffin, J.D.2    Kaushansky, K.3
  • 21
    • 0029584186 scopus 로고
    • Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in a human thrombopoietin-dependent cell line
    • Yamada M, Komatsu N, Okada K, Kato T, Miyazaki H, Miura Y: Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in a human thrombopoietin-dependent cell line. Biochem Biophys Res Commun 217:230, 1995
    • (1995) Biochem Biophys Res Commun , vol.217 , pp. 230
    • Yamada, M.1    Komatsu, N.2    Okada, K.3    Kato, T.4    Miyazaki, H.5    Miura, Y.6
  • 24
    • 0030597210 scopus 로고    scopus 로고
    • Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation
    • Morita H, Tahara T, Matsumoto A, Kato T, Miyazaki H, Ohashi H: Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation. FEBS Lett 395:228, 1996
    • (1996) FEBS Lett , vol.395 , pp. 228
    • Morita, H.1    Tahara, T.2    Matsumoto, A.3    Kato, T.4    Miyazaki, H.5    Ohashi, H.6
  • 25
    • 0030052617 scopus 로고    scopus 로고
    • Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets
    • Miyakawa Y, Oda A, Druker BJ, Miyazaki H, Handa M, Ohashi H, Ikeda Y: Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets. Blood 87:439, 1996
    • (1996) Blood , vol.87 , pp. 439
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3    Miyazaki, H.4    Handa, M.5    Ohashi, H.6    Ikeda, Y.7
  • 26
    • 0029800869 scopus 로고    scopus 로고
    • Tyrosine-599 of the c-Mpl receptor is required for Shc phosphorylation and the induction of cellular differentiation
    • Alexander WS, Maurer AB, Novak U, Harrison Smith M: Tyrosine-599 of the c-Mpl receptor is required for Shc phosphorylation and the induction of cellular differentiation. EMBO J 15:6531, 1996
    • (1996) EMBO J , vol.15 , pp. 6531
    • Alexander, W.S.1    Maurer, A.B.2    Novak, U.3    Harrison Smith, M.4
  • 27
    • 0029049709 scopus 로고
    • Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and She phosphorylation
    • Gurney AL, Wong SC, Henzel WJ, de Sauvage FJ: Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and She phosphorylation. Proc Natl Acad Sci USA 92:5292, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5292
    • Gurney, A.L.1    Wong, S.C.2    Henzel, W.J.3    De Sauvage, F.J.4
  • 29
    • 0025323686 scopus 로고
    • Rapid activation by erythropoietin of protein kinase C in nuclei of erythroid progenitor cells
    • Mason Garcia M, Weill CL, Beckman BS: Rapid activation by erythropoietin of protein kinase C in nuclei of erythroid progenitor cells. Biochem Biophys Res Commun 168:490, 1990
    • (1990) Biochem Biophys Res Commun , vol.168 , pp. 490
    • Mason Garcia, M.1    Weill, C.L.2    Beckman, B.S.3
  • 30
    • 84993848597 scopus 로고
    • Prolactin-stimulated mitogenesis of cultured astrocytes is mediated by a protein kinase C-dependent mechanism
    • DeVito WJ, Avakian C, Stone S, Okulicz WC: Prolactin-stimulated mitogenesis of cultured astrocytes is mediated by a protein kinase C-dependent mechanism. J Neurochem 60:832, 1993
    • (1993) J Neurochem , vol.60 , pp. 832
    • DeVito, W.J.1    Avakian, C.2    Stone, S.3    Okulicz, W.C.4
  • 31
    • 0026451081 scopus 로고
    • Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
    • Nishizuka Y: Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607, 1992
    • (1992) Science , vol.258 , pp. 607
    • Nishizuka, Y.1
  • 32
    • 0029060391 scopus 로고
    • Protein kinase C and lipid signaling for sustained cellular responses
    • Nishizuka Y: Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9:484, 1995
    • (1995) FASEB J , vol.9 , pp. 484
    • Nishizuka, Y.1
  • 33
    • 0027322679 scopus 로고
    • Protein kinase C isoenzymes: Divergence in signal transduction?
    • Hug H, Sarre TF: Protein kinase C isoenzymes: Divergence in signal transduction? Biochem J 291:329, 1993
    • (1993) Biochem J , vol.291 , pp. 329
    • Hug, H.1    Sarre, T.F.2
  • 34
    • 0028355443 scopus 로고
    • Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells
    • Whetton AD, Heyworth CM, Nicholls SE, Evans CA, Lord JM, Dexter TM, Owen Lynch PJ: Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells. J Cell Biol 125:651, 1994
    • (1994) J Cell Biol , vol.125 , pp. 651
    • Whetton, A.D.1    Heyworth, C.M.2    Nicholls, S.E.3    Evans, C.A.4    Lord, J.M.5    Dexter, T.M.6    Owen Lynch, P.J.7
  • 35
    • 13344276586 scopus 로고    scopus 로고
    • Inhibition of protein kinase C suppresses megakaryocytic differentiation and stimulates erythroid differentiation in HEL cells
    • Hong Y, Martin JF, Vainchenker W, Erusalimsky JD: Inhibition of protein kinase C suppresses megakaryocytic differentiation and stimulates erythroid differentiation in HEL cells. Blood 87:123, 1996
    • (1996) Blood , vol.87 , pp. 123
    • Hong, Y.1    Martin, J.F.2    Vainchenker, W.3    Erusalimsky, J.D.4
  • 36
    • 0031039145 scopus 로고    scopus 로고
    • The role of serine/threonine phosphorylation in hematopoietic cytokine receptor signal transduction
    • Mufson RA: The role of serine/threonine phosphorylation in hematopoietic cytokine receptor signal transduction. FASEB J 11:37, 1997
    • (1997) FASEB J , vol.11 , pp. 37
    • Mufson, R.A.1
  • 37
    • 0023052241 scopus 로고
    • Studies and perspectives of protein kinase C
    • Nishizuka Y: Studies and perspectives of protein kinase C. Science 233:305, 1986
    • (1986) Science , vol.233 , pp. 305
    • Nishizuka, Y.1
  • 38
    • 0021752587 scopus 로고
    • Role of phorbol diesters in in vitro murine megakaryocyte colony formation
    • Long MW, Smolen JE, Szczepanski P, Boxer LA: Role of phorbol diesters in in vitro murine megakaryocyte colony formation. J Clin Invest 74:1686, 1984
    • (1984) J Clin Invest , vol.74 , pp. 1686
    • Long, M.W.1    Smolen, J.E.2    Szczepanski, P.3    Boxer, L.A.4
  • 39
    • 0002865059 scopus 로고    scopus 로고
    • Cellular model systems to study megakaryocyte differentiation
    • Watson SP, Authi KS (eds): Oxford, UK, IRL
    • Erusalimsky JD, Martin JF: Cellular model systems to study megakaryocyte differentiation, in Watson SP, Authi KS (eds): Platelets, a Practical Approach. Oxford, UK, IRL, 1996, p 27
    • (1996) Platelets, a Practical Approach , pp. 27
    • Erusalimsky, J.D.1    Martin, J.F.2
  • 40
    • 0026034133 scopus 로고
    • Establishment and characterization of a human leukemic cell line with megakaryocytic features: Dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival
    • Komatsu N, Nakauchi H, Miwa A, Ishihara T, Eguchi M, Moroi M, Okada M, Sato Y, Wada H, Yawata Y, Suda T, Miura Y: Establishment and characterization of a human leukemic cell line with megakaryocytic features: Dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival. Cancer Res 51:341, 1991
    • (1991) Cancer Res , vol.51 , pp. 341
    • Komatsu, N.1    Nakauchi, H.2    Miwa, A.3    Ishihara, T.4    Eguchi, M.5    Moroi, M.6    Okada, M.7    Sato, Y.8    Wada, H.9    Yawata, Y.10    Suda, T.11    Miura, Y.12
  • 41
    • 0027074864 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor and erythropoietin act competitively to induce two different programs of differentiation in the human pluripotent cell line UT-7
    • Hermine O, Mayeux P, Titeux M, Mitjavila MT, Casadevall N, Guichard J, Komatsu N, Suda T, Miura Y, Vainchenker W, Breton-Gorius J: Granulocyte-macrophage colony-stimulating factor and erythropoietin act competitively to induce two different programs of differentiation in the human pluripotent cell line UT-7. Blood 80:3060, 1992
    • (1992) Blood , vol.80 , pp. 3060
    • Hermine, O.1    Mayeux, P.2    Titeux, M.3    Mitjavila, M.T.4    Casadevall, N.5    Guichard, J.6    Komatsu, N.7    Suda, T.8    Miura, Y.9    Vainchenker, W.10    Breton-Gorius, J.11
  • 42
    • 0030997437 scopus 로고    scopus 로고
    • Thrombopoietin does not induce lineage-restricted commitment of Mpl-R expressing pluripotent progenitors but permits their complete erythroid and megakaryocytic differentiation
    • Goncalves F, Lacout C, Villeval JL, Wendung F, Vainchenker W, Dumenil D: Thrombopoietin does not induce lineage-restricted commitment of Mpl-R expressing pluripotent progenitors but permits their complete erythroid and megakaryocytic differentiation. Blood 89:3544, 1997
    • (1997) Blood , vol.89 , pp. 3544
    • Goncalves, F.1    Lacout, C.2    Villeval, J.L.3    Wendung, F.4    Vainchenker, W.5    Dumenil, D.6
  • 43
    • 0024239024 scopus 로고
    • Construction and use of a safe and efficient amphotropic packaging cell line
    • Markowitz D, Goff S, Bank A: Construction and use of a safe and efficient amphotropic packaging cell line. Virology 167:400, 1988
    • (1988) Virology , vol.167 , pp. 400
    • Markowitz, D.1    Goff, S.2    Bank, A.3
  • 44
    • 0030589047 scopus 로고    scopus 로고
    • A glass fiber/ diethylaminoethyl double filter binding assay that measures apoptotic internucleosomal DNA fragmentation
    • Erusalimsky JD, John J, Hong Y, Moore M: A glass fiber/ diethylaminoethyl double filter binding assay that measures apoptotic internucleosomal DNA fragmentation. Anal Biochem 242:187, 1997
    • (1997) Anal Biochem , vol.242 , pp. 187
    • Erusalimsky, J.D.1    John, J.2    Hong, Y.3    Moore, M.4
  • 45
    • 0027370523 scopus 로고
    • Antimicrotubule agents induce polyploidization of human leukaemic cell lines with megakaryocytic features
    • van der Loo B, Hong Y, Hancock V, Martin JF, Erusalimsky JD: Antimicrotubule agents induce polyploidization of human leukaemic cell lines with megakaryocytic features. Eur J Clin Invest 23:621, 1993
    • (1993) Eur J Clin Invest , vol.23 , pp. 621
    • Van Der Loo, B.1    Hong, Y.2    Hancock, V.3    Martin, J.F.4    Erusalimsky, J.D.5
  • 47
    • 0023605430 scopus 로고
    • The HL-60 promyelocytic leukemia cell line: Proliferation, differentiation, and cellular oncogene expression
    • Collins SJ: The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood 70: 1233, 1987
    • (1987) Blood , vol.70 , pp. 1233
    • Collins, S.J.1
  • 48
    • 0029921175 scopus 로고    scopus 로고
    • Lineage commitment of transformed haematopoietic progenitors is determined by the level of PKC activity
    • Rossi F, McNagny M, Smith G, Frampton J, Graf T: Lineage commitment of transformed haematopoietic progenitors is determined by the level of PKC activity. EMBO J 15:1894, 1996
    • (1996) EMBO J , vol.15 , pp. 1894
    • Rossi, F.1    McNagny, M.2    Smith, G.3    Frampton, J.4    Graf, T.5
  • 49
    • 0021812451 scopus 로고
    • Altered cytosol/ membrane enzyme redistribution on interleukin-3 activation of protein kinase C
    • Farrar WL, Thomas TP, Anderson WB: Altered cytosol/ membrane enzyme redistribution on interleukin-3 activation of protein kinase C. Nature 315:235, 1985
    • (1985) Nature , vol.315 , pp. 235
    • Farrar, W.L.1    Thomas, T.P.2    Anderson, W.B.3
  • 53
    • 0023025201 scopus 로고
    • Early signals in the mitogenic response
    • Rozengurt E: Early signals in the mitogenic response. Science 234:161, 1986
    • (1986) Science , vol.234 , pp. 161
    • Rozengurt, E.1
  • 54
    • 0027412647 scopus 로고
    • Haemopoietic stem cell development to neutrophils is associated with subcellular redistribution and differential expression of protein kinase C subspecies
    • Shearman MS, Heyworth CM, Dexter TM, Haefner B, Owen PJ, Whetton AD: Haemopoietic stem cell development to neutrophils is associated with subcellular redistribution and differential expression of protein kinase C subspecies. J Cell Sci 104:173, 1993
    • (1993) J Cell Sci , vol.104 , pp. 173
    • Shearman, M.S.1    Heyworth, C.M.2    Dexter, T.M.3    Haefner, B.4    Owen, P.J.5    Whetton, A.D.6
  • 55
    • 0030014746 scopus 로고    scopus 로고
    • Protein kinase C delta specifically associates with phosphatidylinositol 3-kinase following cytokine stimulation
    • Ettinger SL, Lauener RW, Duronio V: Protein kinase C delta specifically associates with phosphatidylinositol 3-kinase following cytokine stimulation. J Biol Chem 271:14514, 1996
    • (1996) J Biol Chem , vol.271 , pp. 14514
    • Ettinger, S.L.1    Lauener, R.W.2    Duronio, V.3
  • 56
    • 0026614362 scopus 로고
    • PKC epsilon is involved in granulocyte-macrophage colony-stimulating factor signal transduction: Evidence from microphysiometry and anti-sense oligonucleotide experiments
    • Baxter GT, Miller DL, Kuo RC, Wada HG, Owicki JC: PKC epsilon is involved in granulocyte-macrophage colony-stimulating factor signal transduction: Evidence from microphysiometry and anti-sense oligonucleotide experiments. Biochemistry 31:10950, 1992
    • (1992) Biochemistry , vol.31 , pp. 10950
    • Baxter, G.T.1    Miller, D.L.2    Kuo, R.C.3    Wada, H.G.4    Owicki, J.C.5
  • 57
    • 0028175091 scopus 로고
    • Raf meets Ras: Completing the framework of a signal transduction pathway
    • Avruch J, Zhang XF, Kyriakis JM: Raf meets Ras: Completing the framework of a signal transduction pathway. Trends Biochem Sci 19:279, 1994
    • (1994) Trends Biochem Sci , vol.19 , pp. 279
    • Avruch, J.1    Zhang, X.F.2    Kyriakis, J.M.3
  • 58
    • 0027996763 scopus 로고
    • Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: Reconstitution of the signalling pathway in vitro
    • Marquardt B, Frith D, Stabel S: Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: Reconstitution of the signalling pathway in vitro. Oncogene 9:3213, 1994
    • (1994) Oncogene , vol.9 , pp. 3213
    • Marquardt, B.1    Frith, D.2    Stabel, S.3
  • 59
    • 0031000626 scopus 로고    scopus 로고
    • Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase
    • Whalen AM, Galasinski SC, Shapiro PS, Nahreini TS, Ahn NG: Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase. Mol Cell Biol 17:1947, 1997
    • (1997) Mol Cell Biol , vol.17 , pp. 1947
    • Whalen, A.M.1    Galasinski, S.C.2    Shapiro, P.S.3    Nahreini, T.S.4    Ahn, N.G.5
  • 60
    • 0030916345 scopus 로고    scopus 로고
    • Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: Involvement of cyclin-dependent kinase inhibitor p21 in polyploidization
    • Kikuchi J, Furukawa Y, Iwase S, Terui Y, Nakamura M, Kitagawa S, Kitagawa M, Komatsu N, Miura Y: Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: Involvement of cyclin-dependent kinase inhibitor p21 in polyploidization. Blood 89:3980, 1997
    • (1997) Blood , vol.89 , pp. 3980
    • Kikuchi, J.1    Furukawa, Y.2    Iwase, S.3    Terui, Y.4    Nakamura, M.5    Kitagawa, S.6    Kitagawa, M.7    Komatsu, N.8    Miura, Y.9


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