Effect of dehydroleucodine in experimental colitis in rats and mice

Pharmacological Research

Volumn 40, Issue 4, 1999, Pages 339-344

  Wendel, G H ^a   Maria, A O M ^a   Mohamed, F ^a   Dominguez, S ^a   Scardapane, L ^a   Giordano, O S ^a   Guerreiro, E ^a   Guzman, J A ^a  

^a UNIVERSIDAD NACIONAL DE SAN LUIS   (Argentina)

Author keywords

Acetic acid; Dehydroleucodine; Experimental colitis

Indexed keywords

ACETIC ACID; CYCLOOXYGENASE 2; DEHYDROLEUCODINE; GLYCOPROTEIN; GUAIANOLIDE DERIVATIVE; SESQUITERPENE LACTONE; TRINITROBENZENESULFONIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTEMISIA; ARTICLE; CELL PROTECTION; COLITIS; COLON MUCOSA; COLON ULCER; CONTROLLED STUDY; DEGRANULATION; DIARRHEA; DUODENUM DISEASE; GLYCOPROTEIN SYNTHESIS; INTESTINE NECROSIS; MOUSE; MUCUS SECRETION; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; RAT; STOMACH LESION;

ARTEMISIA DOUGLASIANA;

EID: 0032864054     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1999.0521     Document Type: Article

References (29)

1. Giordano O S, Guerreiro E, Pestchanker M J, Guzman J A, Pastor D, Guardia T. The gastric cytoprotective effect of several sesquiterpene lactones. J Nat Prod. 53:1990;803-809.
2. Piezzi R, Guzmán J, Guardia T, Pestchanker M, Guerreiro O, Giordano O. Dehydroleucodine prevents ethanol-induced necrosis in the rat gastric mucosa. Micr Elect Biol Cell. 16:1992;45-56.
3. Guardia T, Guzmán J A, Pestchanker M, Guerreiro E, Giordano O. Mucus synthesis and sulfhydryle groups in cytoprotection mediates by dehydroleucodine, a sesquiterpene lactone. J Nat Prod. 57:1994;507-509.
4. Piezzi R, Guzmán J, Guardia T, Pestchanker M, Guerreiro E, Giordano O. Dehydroleucodine prevents ethanol-induced necrosis in the mice duodenal mucosa. Micr Elect Biol Cell. 19:1995;27-33.
5. Ariza-Espinar O. Contribución al conocimiento de las compositae adventicias de la Argentina. Kurtzian. 4:1967;73-82.
6. Hanauer S. Medical therapy of ulcerative colitis. Lancet. 342:1993;412-417.
7. Hoshino H, Goto H, Sugiyama S, Hayakawa T, Ozawa T. Effects of FK506 on an experimental model of colitis in rats. Aliment Pharmacol Ther. 9:1995;301-307.
8. Strober W. Animal models of inflammatory bowel disease - An overview. Dig Dis Sci. 1985;3-10.
9. Kim H, Berstad A. Experimental colitis in animal models. Scand J Gastroenterol. 27:1992;529-537.
10. Madara J, Podolsky D, King N, Sehal P, Moore R, Winter H. Characterization of spontaneous colitis in cotton-top tamarins (Sanguines oedipus) and its response to sulfasalazine. Gastroenterology. 88:1995;13-19.
11. Morris G P, Beck P L, Herridge M S, Depew W T, Szewczuk Z MR, Wallace J L. A hapten-induced model of chronic inflammation and ulceration in rat colon. Gastroenterology. 96:1989;795-803.
12. MacPherson B R, Pfeiffer C J. Experimental production of diffuse colitis in rats. Digestion. 17:1978;124-150.
13. Karmeli F, Eliakim R, Okon E, Samuni A, Rachmilewitz D. A stable nitroxide radical effectively decreases mucosal damage in experimental colitis. Gut. 37:1995;386-393.
14. Eliakim R, Karmeli F, Okon E, Rachmilewitz D. Ketotifen effectively prevents mucosal damage in experimental colitis. Gut. 1992;1498-1503.
15. Wallace J L, Braquet P, Ibbotson G C, MacNaughton W K, Cirino G. Assessment of the role of platelet activating factor in an animal model of inflammatory bowel disease. J Lipid Med. 1:1989;13-23.
16. LeDuc L, Su K, Guth E, Reedt T, Guth P. Effects of cyclooxygenase and l ipooxygenase inhibition on eicosanoids and healing of acetic acid colitis in rats. Dig Dis Sci. 38:1993;289-294.
17. Satoh H, Sato F, Takami K, Szabo S. New ulcerative colitis model induced by sulphydryl blockers in rats and effects of antiinflammatory drugs on the colitis. Jpn J Pharmacol. 73:1997;299-309.
18. Chin K, Barret K. Mast cell are not essential to inflammation in murine model of colitis. Dig Dis Sci. 39:1994;513-525.
19. Zahavi Y, Burg Z, Marcus H, Karmeli F, Nusinovitz M, Dinari G. Therapeutic effect of colloid bismuth subcitrate in experimental colitis in the rat. Digestion. 56:1995;211-213.
20. Mascolo N, Izzo A, Autore G, Maiello F, Di Carlo G, Capasso F. Acetic acid-induced colitis in normal and essential fatty acid deficient rats. J Pharmacol Exp Ther. 272:1995;469-475.
21. Mann N S, Mann S K, Cheung E C. Fiberoptic colonoscopic study of experimental chemical colitis. Gastrointest Endosc. 26:1980;38.
22. Zahavi Y, Avidor Y, Marcus H, Rosenbach Y, Waissman Y, Ligumsky M, Dinari G. Effect of sucralfate on experimental colitis in the rat. Dis Colon Rectum. 312:1989;95-98.
23. Rachmilewitz D, Simon P L, Schwartz L W, Don Griswold E, Fondacaro J D, Wassermann M A. Inflammatory mediators of experimental colitis in rats. Gastroenterology. 97:1989;326-337.
24. Giordano O, Pestchanker M, Guerreiro E, Saad J, Enriz R, Rodriguez A, Jauregui E, Guzmán J, María A, Wendel G. J Med Chem. 1992;. p. 2452-8.
25. Penissi A, Fogal T H, Guzmán J A, Piezzi R S. Gastroduodenal mucosal protection induced by dehydroleucodine. Dig Dis Sci. 43:1998;791-798.
26. Hall I H, Lee K H, Starnes C O, Sumida Y, Wu R Y, Waddell T G, Cochran J W, Gerhart K G. Anti-inflammatory activity of sesquiterpene lactones and related compounds. J Pharm Sci. 66:1979;537-542.
27. Bork P M, Lienhard Schmitz M, Kuhnt M, Escher C, Heinrich M. Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-κB. Letters. 402:1997;85-90.
28. Conner E M, Brand S, Grisham M B. Inhibition of chronic granulomatous colitis by a selective proteasome inhibitor: antagonist of nuclear transcription factor KB (NF-κB) activation. Br J Pharmacol. 124:1998;431-433.
29. Tambe Y, Tsujiuchi H, Honda G, Ikeshiro Y, Tanaka S. Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, β caryophillene. Planta Med. 62:1996;469-470.