The role of Rho GTPases and associated kinases in regulating neurite outgrowth

International Journal of Biochemistry and Cell Biology

Volumn 34, Issue 7, 2002, Pages 731-745

  Nikolic, Margareta ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cytoskeleton; Kinases; Neurite outgrowth; Neurones; Rho GTPases

Indexed keywords

ACTIN; CYCLIN DEPENDENT KINASE; PROTEIN CDC42; PROTEIN P35; PROTEIN P39; RAC PROTEIN; RHO FACTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; CELL MIGRATION; CELL TYPE; CYTOSKELETON; DOWN REGULATION; ENZYME ACTIVATION; ENZYME REGULATION; GROWTH REGULATION; MOLECULAR MECHANICS; MUSCLE CONTRACTILITY; NERVE FIBER GROWTH; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; POLYMERIZATION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW;

ANIMALS; CDC42 GTP-BINDING PROTEIN; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASES; HUMANS; MODELS, NEUROLOGICAL; NEURITES; PROTEIN-SERINE-THREONINE KINASES; RAC1 GTP-BINDING PROTEIN; RHO GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN;

EID: 0036223437     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(01)00167-4     Document Type: Review

References (132)

1. The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
2. The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling
3. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
4. Rho GTPases: Molecular switches that control the organization and dynamics of the actin cytoskeleton
5. Rho GTPases in neuronal morphogenesis
6. Rho GTPases in growth cone guidance
7. Ras and Rho GTPases: A family reunion
8. The role of Notch and Rho GTPase signaling in the control of dendritic development
9. Rho GTPases: Signaling, migration, and invasion
10. Growth cone guidance: First steps towards a deeper understanding
11. Molecular basis of semaphorin-mediated axon guidance
12. Semaphorins and their receptors in vertebrates and invertebrates
13. Positive feedback interactions between microtubule and actin dynamics during cell motility
14. A role of microtubules during the formation of cell processes in neuronal and non-neuronal cells
15. Microtubules and neuronal polarity: Lessons from mitosis
16. Rho GTPases and signaling networks
17. Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme
18. Oligophrenin-1 encodes a RhoGAP protein involved in X-linked mental retardation
19. p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation
20. Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins
21. Alpha2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells
22. A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways
23. Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1
24. Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth
25. Expression of kalirin, a neuronal GDP/GTP exchange factor of the trio family, in the central nervous system of the adult rat
26. RhoGDIgamma: A GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas
27. Axon formation: A molecular model for the generation of neuronal polarity
28. The role of local actin instability in axon formation
29. The neuronal architecture of Xenopus retinal ganglion cells is sculpted by rho-family GTPases in vivo
30. Rac1-dependent actin filament organization in growth cones is necessary for beta1-integrin-mediated advance but not for growth on poly-D-lysine
31. Small GTPases in axon outgrowth
32. Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesis
33. Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42
34. Multiple roles of EPH receptors and ephrins in neural development
35. Eph receptors and ephrins
36. Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase
37. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin
38. Plexin signaling via off-track and Rho family GTPases
39. Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho
40. Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling
41. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner
42. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
43. Drosophila Rac1 controls motor axon guidance
44. Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo
45. Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines
46. Maintenance of CDC42 GDP-bound state by Rho-GDI inhibits MAP kinase activation by the exchange factor Ras-GRF. Evidence for Ras-GRF function being inhibited by Cdc42-GDP but unaffected by CDC42-GTP
47. Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex
48. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
49. A family of human cdc2-related protein kinases
50. The role of the p35/cdk5 kinase in cortical development
51. The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning
52. Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction
53. The role of the Cdk5-p35 kinase in neuronal development
54. Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system
55. Localization and developmental changes in the neuron-specific cyclin-dependent kinase 5 activator (p35nck5a) in the rat brain
56. Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse
57. Changes in the expression of novel Cdk5 activator messenger RNA (p39nck5ai mRNA) during rat brain development
58. The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity
59. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation
60. Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons
61. Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth
62. Integrin alpha(1) beta(1)-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human neurofilament protein H Lys-Ser-Pro tail domain phosphorylation
63. Role of cyclins in neuronal differentiation of immortalized hippocampal cells
64. Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality
65. A novel disruption of cortical development in p35(-/-) mice distinct from reeler
66. Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex
67. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death
68. Migration defects of cdk5(-/-) neurons in the developing cerebellum is cell autonomous
69. Neuronal cyclin-dependent kinase 5 activity is critical for survival
70. Callosal axon guidance defects in p35(-/-) mice
71. The cyclin-dependent kinase Cdk5 controls multiple aspects of axon patterning in vivo
72. Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism
73. The role of the Cdk5 - p35 kinase in neuronal development
74. Pak to the future
75. Roles of PAK family kinases
76. p21-activated protein kinase: A crucial component of morphological signaling?
77. The Ste20 group kinases as regulators of MAP kinase cascades
78. Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes
79. Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family
80. A conserved negative regulatory region in alphaPAK: Inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1
81. Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
82. Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck
83. Mechanism of activation of Pak1 kinase by membrane localization
84. Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells
85. PAK promotes morphological changes by acting upstream of Rac
86. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila
87. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity
88. Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase
89. Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila
90. Distribution of Rho-kinase in the bovine brain
91. Regulation and functions of Rho-associated kinase
92. RhoA-binding kinase alpha translocation is facilitated by the collapse of the vimentin intermediate filament network
93. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes
94. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho
95. Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells
96. A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons
97. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells
98. Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse
99. A family of proteins implicated in axon guidance and outgrowth
100. A family of rat CRMP genes is differentially expressed in the nervous system
101. A novel regulator of p21-activated kinases
102. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
103. Interaction between PAK and Nck: A template for Nck targets and role of PAK autophosphorylation
104. Molecular cloning of neuronally expressed mouse betaPix isoforms
105. Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization
106. The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells
107. A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
108. The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors
109. Stimulation of Ras guanine nucleotide
110. Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology
111. Drosophila abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled
112. The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance
113. From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility
114. Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth
115. Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK
116. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
117. Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
118. Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase
119. Two activities of cofilin, severing and accelerating directional depolymerization of actin filaments, are affected differentially by mutations around the actin-binding helix
120. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
121. Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse
122. Comparison of tissue distribution of two novel serine/threonine kinase genes containing the LIM motif (LIMK-1 and LIMK-2) in the developing rat
123. Identification of testis-specific (Limk2t) and brain-specific (Limk2c) isoforms of mouse LIM-kinase 2 gene transcripts
124. Williams syndrome: From genotype through to the cognitive phenotype
125. The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology
126. PAK3 mutation in nonsyndromic X-linked mental retardation
127. Missense mutation in PAK3, R67C, causes X-linked nonspecific mental retardation
128. Rac/Cdc42 Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16
129. The Ras-related GTPase Rac1 binds tubulin
130. Localized Rac activation dynamics visualized in living cells
131. Using GFP in FRET-based applications