Hodgkin's lymphoma: The pathologist's viewpoint

Journal of Clinical Pathology

Volumn 55, Issue 3, 2002, Pages 162-176

  Pileri, S A ^a   Ascani, S ^a   Leoncini, L ^b   Sabattini, E ^a   Zinzani, P L ^a   Piccaluga, P P ^a   Pileri Jr , A ^a   Giunti, M ^a   Falini, B ^c   Bolis, G B ^c   Stein, H ^d  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF PERUGIA   (Italy)

^d FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

B LYMPHOCYTE; CARCINOGENESIS; CELLULAR DISTRIBUTION; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; DISEASE CLASSIFICATION; EPSTEIN BARR VIRUS; GENOTYPE; HISTOGENESIS; HISTOPATHOLOGY; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; LYMPHOCYTE DEPLETION; MORPHOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SCLEROSIS; WORLD HEALTH ORGANIZATION;

EID: 0036206437     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.55.3.162     Document Type: Review

References (193)

1. Immunoglobulin V genes in Reed-Sternberg cells
2. Origin of nodular lymphocyte predominant Hodgkin's disease from a clonal expansion of highly mutated germinal center B cells
3. Monoclonal IgH gene rearrangement in microdissected nodules from nodular sclerosis Hodgkin's disease
4. Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma
5. Cellular origin of human B-cell lymphomas
6. The World Health Organization classification of neoplastic diseases of the haematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997
7. Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangement but defective immunoglobulin transcription
8. Detection of clonal T-cell receptor gamma-chain gene-rearrangements in Reed-Sternberg cells of classic Hodgkin's disease
9. Introduction: Hodgkin's lymphoma - Pathology, pathogenesis, and treatment
10. Hodgkin's disease: Classification and differential diagnosis
11. CD30 (Ki-1) molecule: A new cytokine receptor of tumor necrosis factor superfamily as a tool for diagnosis and immunotherapy
12. Cytokines and cytokine receptors in Hodgkin's disease
13. Immune reactions in classical Hodgkin's lymphoma
14. Basic fibroblast growth factor and fibrosis in Hodgkin's disease
15. High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltrate in Hodgkin's lymphoma
16. Expression of c-met proto-oncogene and its ligand hepatocyte growth factor in Hodgkin's disease
17. A revised European-American classification of lymphoid neoplasms: A proposal from the international lymphoma study group
18. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997
19. European task force on lymphoma project on lymphocyte predominance Hodgkin disease: Histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes
20. Hodgkin's lymphomas: Classification, diagnosis, and grading
21. Hodgkin's disease with lymphocytic predominance, nodular type (nodular paragranuloma) and progressively transformed germinal centers: A cytohistologic study
22. Nodular lymphocyte predominance Hodgkin's disease: A distinct clinicopathologic entity
23. Evidence of an orderly progression in the spread of Hodgkin's disease
24. Nodular and diffuse types of lymphocyte predominance Hodgkin's disease
25. Composite lymphoma and related disorders
26. Lymphocyte-predominant Hodgkin's disease: An immunohistochemical analysis of 208 reviewed Hodgkin's disease cases from the German Hodgkin study group
27. Histiocyte-rich B-cell lymphoma. A distinct clinicopathologic entity possibly related to lymphocyte predominant Hodgkin's disease, paragranuloma subtype
28. Progressive transformation of germinal centers and nodular lymphocyte predominance Hodgkin's disease. A comparative immunohistochemical study
29. Downregulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin's disease but not in lymphocyte predominant Hodgkin's disease correlates with immunoglobulin transcription
30. The BOB.1/OBF.1 co-activator is essential for octamer-dependent transcription in B cells
31. In vivo expression of the B7 costimulatory molecule by subsets of antigen-presenting cells and the malignant cells of Hodgkin's disease
32. Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines
33. Nodular lymphocyte predominance type of Hodgkin's disease is a germinal center lymphoma
34. Diffuse lymphocyte-predominant Hodgkin's disease (diffuse paragranuloma). A variant of the B-cell-derived nodular type
35. Lymphocyte predominance Hodgkin's disease. The use of bcl-6 and CD57 in diagnosis and differential diagnosis
36. Differential diagnosis between classic Hodgkin's lymphoma, T-cell-rich B-cell lymphoma, and paragranuloma by paraffin immunohistochemistry
37. Correlation of the expression of Epstein-Barr virus latent membrane protein and in situ hybridization with biotinylated BamH1-W probes in Hodgkin's disease
38. Epstein-Barr virus infection and the pathogenesis of malignant lymphomas
39. Hodgkin's disease
40. The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells
41. Hodgkin's disease: Update of findings
42. The nature of Hodgkin and Reed-Sternberg cells, their association with EBV, and their relationship to anaplastic large-cell lymphoma
43. Ber-H2: A new anti-Ki-1 (CD-30) monoclonal antibody directed at a formol resistant epitope. Immunohistochemical and immunobiochemical characterization
44. Molecular cloning and expression of a new member of the nerve growth factor receptor family which is characteristic for Hodgkin's disease
45. Soluble molecules as biological markers in Hodgkin's disease
46. Response of refractory Hodgkin's disease to monodonal anti-CD30 immunotoxin
47. Ber-H2 (anti CD30)-saporin immunotoxin: A new tool for the treatment of Hodgkin's disease and CD30+ lymphoma. In vitro evaluation
48. Experimental treatment of human Hodgkin's disease with ricin A-chain immunotoxins
49. Anti-CD30 (Ber=H2) immunotoxins containing the type-1 ribosome-inactivating proteins momordin and PAP-S (pokeweed antiviral protein from seeds) display powerful activity against CD30+ tumour cells in vitro and in SCID mice
50. CD30 (Ber-H2) expression in nonhematopoietic tumors
51. Antigen retrieval techniques in immunohistochemistry: Comparison of different methods
52. Is Hodgkin's disease a unique entity?
53. Peripheral T-cell lymphomas. Clinico-pathologic study of 168 cases diagnosed according to the REAL classification
54. Variable expression of leukocyte common antigen (CD45) in CD30 (Ki-1)-positive anaplastic large cell (ALC) lymphoma. Implication for the differential diagnosis between lymphoid and non-lymphoid malignancies
55. The expression of the B-cell marker mb-1 (CD79a) in Hodgkin's disease
56. CD20: A review
57. CD30 (Ki-1)-positive malignant lymphomas: Clinical, immunophenotypic, histologic, and genetic characteristics and differences with Hodgkin's disease
58. Epithelial membrane antigen in hematolymphoid neoplasms. A review
59. Varied B-cell immunophenotypes of Hodgkin/Reed-Sternberg cells in classic Hodgkin's disease
60. Expression of T-cell antigens on Hodgkin's and Sternberg-Reed cells of Hodgkin's disease. A combined immunocytochemical and immunohistological study using monoclonal antibodies
61. Immunophenotype of Reed-Sternberg cells: A study of 19 cases of Hodgkin's disease in plastic-embedded sections
62. Rare occurrence of classical Hodgkin's disease as a T-cell lymphoma
63. A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells
64. Tumor cell growth fraction in Hodgkin's disease
65. Comparison between the monoclonal antibodies Ki-67 and PC10 in 125 malignant lymphomas
66. Apoptosis in Hodgkin's disease: An in situ endlabelling study correlated with proliferation indices and expression of cell death gene, p53 and BCL-2
67. Abortive mitosis and nuclear DNA fragmentation in CD30+ large cells of Hodgkin's disease
68. Growth vs DNA strand breaks in Hodgkin's disease: Impaired proliferative ability of Hodgkin and Reed-Sternberg cells
69. Mitotic activity and nuclear DNA damage of large cells in Hodgkin's disease: Comparison with the expression of p53 and bcl-2 proteins and the presence of Epstein-Barr virus
70. Classical Hodgkin's disease: Clinical impact of the immunophenotype
71. A study of p53 protein, proliferating cell nuclear antigen, and p21 in Hodgkin's disease at presentation and relapse
72. Prognostic factors in Hodgkin's disease: Multivariate analysis of 327 patients from a single institution
73. The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease
74. High level nuclear NF-κB and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells
75. Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells
76. Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for the IkappaBalpha
77. Clonal deleterious mutations in the IκBα gene in the malignant cells in Hodgkin's lymphoma
78. Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells
79. Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease
80. Nucleophosmin (NPM) gene rearrangements in Ki-1 positive lymphomas
81. Large-cell anaplastic lymphoma-specific translocation t(2;5)(p23;q35) in Hodgkin's disease: Indication of a common pathogenesis?
82. NPM/ALK: A distinct clinicopathologic entity
83. Absence of the t(2;5) in Hodgkin's disease
84. Molecular analysis of the NPM-ALK rearrangement in Hodgkin's disease
85. NPM/ALK expression
86. Frequent expression of the p80 NPM-ALK chimeric fusion protein in anaplastic large-cell lymphoma, lympho-histiocytic type
87. Use of an anti-ALK antibody in the characterization of anaplastic large-cell lymphoma of childhood
88. Detection of ALK and NPM-ALK protein in normal and neoplastic cells with the monoclonal antibody ALK1
89. Long-range amplification of genomic DNA detects the t(2;5)(p23;q35) in anaplastic large-cell lymphoma, but not in other non Hodgkin's lymphomas, Hodgkin's disease, or lymphomatoid papulosis
90. NPM/ALK fusion mRNA expression in Hodgkin and Reed-Sternberg cells is rare but does occur: Results from single-cell cDNA analysis
91. ALK-positive lymphoma: A single disease with a broad spectrum of morphology
92. ALK expression defines a distinct group of lymphomas ("ALK lymphomas") with a wide morphologic spectrum
93. Chromosomal abnormalities in patients with Hodgkin's disease: Evidence for frequent involvement of the 14q chromosomal region but infrequent bcl-2 gene rearrangement in Reed-Sternberg cells
94. Detection of Epstein-Barr virus in Hodgkin's disease
95. Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphama cells
96. Neoplastic cells of Hodgkin's disease show differences in EBV expression between Kenya and Italy
97. The consistent association between Epstein-Barr virus and Hodgkin's disease in children in Kenya
98. Persistence of the same viral strain in early and late relapses of Epstein-Barr virus-associated Hodgkin's disease
99. Histologische klassifizierung und vorkommen des M. Hodgkin
100. Maladie de Hodgkin. Une ou plusieurs maladies
101. Relationship of histologic features to survival and relapse in nodular sclerosing Hodgkin's disease. A study of 1659 patients
102. Hodgkin's disease
103. The distinction of Hodgkin's disease from T-cell lymphoma
104. Recent advances in Hodgkin's disease: An overview and review of the literature
105. Follicular dendritic cells have prognostic relevance in Hodgkin's disease
106. Prognostic value of follicular dendritic cells in nodular sclerosing Hodgkin's disease
107. The "syncytial variant" of nodular sclerosing Hodgkin's disease
108. Syncytial variant of nodular sclerosing Hodgkin's disease. A new clinicopathologic entity
109. The prognostic significance of cellular subtypes in nodular sclerosing Hodgkin's disease: An analysis of 271 non-laparotomised cases (BNLI report No 22)
110. Hodgkin's disease, nodular sclerosing type: Implications of histologic subclassification
111. Lack of prognostic value of histopathologic parameters in Hodgkin's disease, nodular sclerosis type: A study of 123 patients with limited stage disease who had undergone laparotomy and were treated with radiation therapy
112. Histopathologic grading of nodular sclerosis Hodgkin's disease. Lack of prognostic significance in 254 surgically staged patients
113. Lymphohistiocytic T-cell lymphoma (anaplastic large cell lymphoma CD30+/Ki-1 + with a high content of reactive histiocytes)
114. Anaplastic large cell lymphoma (CD30+/Ki-1 +): Results of the prospective clinico-pathologic study of 69 cases
115. Controversies on Hodgkin's disease and anaplastic large cell lymphoma. Hematopathology study group of the societa Italiana di anatomia patologica
116. Anaplastic large cell lymphoma: Update of findings
117. Anaplastic large cell lymphoma Hodgkin's like
118. The non-Hodgkin's lymphoma classification project: A clinical evaluation of the international lymphoma study group classification of non-Hodgkin's lymphoma
119. Mediastinal large B-cell lymphoma: Clinical and immunohistochemical findings of 18 patients treated with two different third generation regimens
120. Treatment outcome and prognostic factors for primary mediastinal (thymic) B-cell lymphoma: A multicentric study of 106 patients
121. Primary large cell lymphoma of the mediatinum
122. CD30 expression is common in mediastinal large B-cell lymphoma
123. Mediastinal large B-cell lymphoma vs classic Hodgkin lymphoma
124. The MAL gene is expressed in primary mediastinal large B-cell lymphoma
125. Metastatic carcinoma in lymph nodes simulating syncytial variant of nodular sclerosing Hodgkin's disease
126. Metastatic nasopharyngeal carcinoma initially presenting as cervical lymphadenopathy: A report of twa cases that resembled Hadgkin's disease
127. Interfollicular Hodgkin's disease
128. Hodgkin's disease presenting with the histological features of Castleman's disease
129. Interleukin-6, but not interleukin-4, is expressed by Reed-Sternberg cells in Hodgkin's disease with or without histologic feature of Castleman's disease
130. Criteria for involvement of lymph node, bone marrow, spleen and liver in Hodgkin's disease
131. Cytohistologic and immunohistochemical findings in Hodgkin's disease, mixed cellularity type with a high content of epithelioid cells
132. The histologic diagnosis of Hodgkin's disease
133. Aberrant phenotypes in peripheral T-cell lymphomas
134. Peripheral T-cell lymphoma: A developing concept
135. Differentiation of T-cell lymphoma from Hodgkin's disease: Mitotic rate and S-phase analysis
136. Diffuse B cell lymphomas with T cell predominance in patients with follicular lymphoma or "pseudo T cell lymphoma"
137. T-cell-rich B large-cell lymphoma simulating lymphocyte-rich Hodgkin's disease
138. T-cell-rich B-cell lymphoma
139. T-cell rich B-cell lymphoma: A morphological variety of non-Hodgkin's lymphomas or a clinicopathological entity?
140. Differential diagnosis of L26-positive, CD15-negative Hodgkin's disease and large B-cell lymphoma with a high content of reactive T-cells: A morphologic and immunohistochemical study
141. T-cell-rich B-cell non Hodgkin's lymphoma: A progressed form of follicle center cell lymphoma and lymphocyte predominance Hodgkin's disease
142. Bone marrow involvement in T-cell-rich B-cell lymphoma
143. Absence of dendritic reticulum cell staining is helpful for distinguishing T-cell-rich B-cell lymphoma from lymphocyte predominance Hodgkin's disease
144. Lymphocyte depletion Hodgkin's disease: Histopathologic diagnosis of marrow involvement
145. Ki-1 positive large cell lymphoma, a morphologic and immunologic study of 19 cases
146. Hodgkin's disease in association with human immunodeficiency virus infection
147. Clinical features of 31 patients with Ki-1 anaplastic large-cell lymphoma
148. The pathologic and clinical heterogeneity of lymphocyte-depleted Hodgkin's disease
149. Pleomorphic large cell lymphomas of the mediastinum
150. Critical commentary to "Inflammatory fibrosarcoma: Another imitator of Hodgkin's disease?" Letter to the case
151. Inflammatory fibrosarcoma: Another imitator of Hodgkin's disease?
152. Malignant fibrous histiocytoma: An analysis of 200 cases
153. Lymphocyte-rich well-differentiated liposarcoma: Report of nine cases
154. Paragranuloma is a variant of Hodgkin's disease with predominance of B-cells
155. Correlation of content of B cells and Leu7-positive cells with subtype and stage in lymphocyte predominance type Hodgkin's disease
156. Follicular Hodgkin's disease
157. Lymphocyte predominance Hodgkin's disease: A European task force on lymphoma project
158. Recurrent Hodgkin's disease in treated sites
159. Cancer incidence in a cohort of human immunodeficiency virus seroconverters
160. For the AIDS-cancer match study group: Spectrum of AIDS-associated malignant disorders
161. Hodgkin's disease in patients with antibodies to human immunodeficiency virus
162. Hodgkin's disease and human immunodeficiency virus infection: Clinicopathologic and virologic features of 114 patients from the Italian cooperative group on AIDS and tumors
163. Human immunodeficiency virus-associated Hodgkin's disease derives from post-germinal center B cells
164. Pathological, immunological, and molecular features of Hodgkin's disease associated with HIV infection. Comparison with ordinary Hodgkin's disease
165. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells
166. Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus
167. IARC Monographs on the evaluation of carcinogenic risks to humans
168. Nodular paragranuloma can transform into high-grade malignant lymphoma of B type
169. The interrelationship between Hodgkin's disease and non-Hodgkin's lymphomas
170. Composite lymphoma and related disorders
171. Clonal relationship between lymphocytic predominance Hodgkin's disease and concurrent or subsequent large B-cell lymphoma of B cell lineage
172. Nodular lymphocyte-predominant Hodgkin's disease associated with large cell lymphoma: Analysis of Ig gene rearrangements by V-J polymerase chain reaction
173. Nodular lymphocyte predominance Hodgkin's disease: A monoclonal or polyclonal B-cell disorder?
174. Clonal identification of Burkitt's lymphoma arising from lymphocyte-predominant Hodgkin's disease
175. Common activated helper-T-cell origin for lymphomatoid papulosis, mycosis fungoides, and some types of Hodgkin's disease
176. Monomorphic lymphomas arising in patients w th Hodgkin's disease. Correlation of morphologic immunophenotypic, and molecular genetic findings in 12 cases
177. Hodgkin's disease variant of Richter's syndrome. Report of eight cases
178. Composite lymphoma. A clinicopathologic analysis of nine patients with Hodgkin's disease and B-cell non-Hodgkin's lymphoma
179. Chronic lymphocytic leukemia with coexistent Hodgkin's disease. Implications for the origin of the Reed-Sternberg cell
180. Hodgkin's disease, lymphomatoid papulosis, and cutaneous T-cell lymphoma derived from a common T-cell clone
181. The interrelationship of Hodgkin's disease and non-Hodgkin's lymphoma - Lessons learned from composite and sequential malignancies
182. The relationship between Hodgkin's disease and non-Hodgkin's lymphoma
183. Hodgkin's disease following non-Hodgkin's lymphoma. A clinicopathologic and immunophenotypic study of nine cases
184. The bcl-2 oncogene in Hodgkin's disease arising in the setting of follicular non-Hodgkin lymphoma
185. Hodgkin's disease following mycosis fungoides: Phenotypic and molecular evidence for different tumour cell clones
186. The clonal relationship between nodular sclerosis Hodgkin's disease with clonal Reed-Sternberg cell population and a subsequent B-cell small noncleaved lymphoma
187. Origin of the Hodgkin/Reed-Sternberg cells in chronic lymphocytic leukemia with Hodgkin's transformation
188. Relationship between Hodgkin's disease and non-Hodgkin's lymphomas
189. Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma
190. Classical Hodgkin's disease and follicular lymphoma originating from the same germinal center B cell
191. Immunoglobulin gene rearrangement analysis in Hodgkin's disease associated with large B-cell lymphama in the same patient: Evidence for receptor revision of immunoglobulin heavy chain variable genes in Hodgkin-Reed-Sternberg cells?
192. The transcription factor PU.1, necessary for B-cell development is expressed in lymphocyte predominance, but not classical Hodgkin's disease