CD20: A review

Applied Immunohistochemistry and Molecular Morphology

Volumn 4, Issue 1, 1996, Pages 1-15

  Chang, Karen L ^a   Arber, Daniel A ^a   Weiss, Lawrence M ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

B cell lymphoma; B cell ontogeny; CD20; Immunohistochemistry; Mature B cells

Indexed keywords

CD20 ANTIGEN;

B CELL LYMPHOMA; CANCER IMMUNOTHERAPY; FLOW CYTOMETRY; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; REVIEW;

EID: 0029965313     PISSN: 10623345     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (126)

1. Stashenko P, Nadler LM, Hardy R, Schlossman SF. Characterization of a human B lymphocyte-specific antigen. J Immunol 1980;125:1678-85.
2. Nadler LM. B Cell/Leukemia Panel Workshop: summary and comments. In: Reinherz EL, Haynes BF, Nadler LM, et al., eds. Leukocyte II. Human B lymphocytes. vol. 2 New York: Springer-Verlag, 1986;20:1.
3. Dörken B, Möller P, Pezzutto A, Schwartz-Albiez R, Moldenhauer G. B-cell antigens: section report. In: Knapp W, Dörken B, Gilks WR, et al. eds. Leucotype typing IV. White cell differentiation antigens. Oxford: Oxford University Press, 1989:22.
4. Ishii Y, Takami T, Yuasa H, Takei T, Kikuchi K. Two distinct antigen systems in human B lymphocytes: identification of cell surface and intracellular antigens using monoclonal antibodies. Clin Exp Immunol 1984;58:183-92.
5. Mason DY, Comans-Bitter WM, Cordell JL, Verhoeven M-AJ, van Dongen JJM. Antibody L26 recognizes an intracellular epitope on the B cell-associated CD20 antigen. Am J Pathol 1990;136:1215-22.
6. Pinto A, Gattei V, Soligo D, Parravicini C, Del Vecchio L. New molecules burst at the leukocyte surface. A comprehensive review based on the 5th International Workshop on Leukocyte Differentiation Antigens. Leukemia 1994;8:347-58.
7. Dörken B, Möller P, Pezzutto A, Schwartz-Albiez R, Moldenhauer G. B-cell antigens: unclustered mAb. In: Knapp W, Dörken B, Gilks WR, et al, eds. Leucocyte typing IV. White cell differentiation antigens. Oxford: Oxford University Press, 1989:129-31.
8. Tedder TF, Disteche CM, Louie E, et al. The gene that encodes the human CD20 (B1) differentiation antigen is located on chromosome 11 near the t(11;14)(q13;q32) translocation site. J Immunol 1989;142:2555-2559.
9. Einfeld DA, Brown JP, Valentine MA, Clark EA, Ledbetter JA. Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains. EMBO 1988;7:711-17.
10. Stamenkovic I, Seed B. Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III integral membrane protein. J Exp Med 1988;167:1975-80.
11. Tedder TF, Streuli M, Schlossman SF, Saito H. Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci USA 1988;85:208-12.
12. Tedder TF, Klejman F, Schlossman SF, Saito H. Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1). J Immunol 1989;142:2560-8.
13. Adra CN, Lelias J-M, Kobayashi H, et al. Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the β subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions. Proc Natl Acad Sci USA 1994;91:10178-82.
14. Rieckmann P, Wilson G-L, Thévenin C, Hong J-X, Kehrl JH. Analysis of cis-acting elements present in the CD20/B1 antigen promoter. J Immunol 1991;147:3994-9.
15. Thévenin C, Lucas BP, Kozlow EJ, Kehrl JH. Cell type-and stage-specific expression of the CD20/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter. J Biol Chem 1991;268:5949-56.
16. Tedder TF, Penta A. Structure of the CD20 antigen and gene of human and mouse B-cells: use of transfected cell lines to examine the Workshop panel of antibodies. In: Knapp W, Dörken B, Gilks WR, et al., eds. Leukocyte typing IV. White cell differentiation antigens. Oxford: Oxford University Press, 1989: pp. 48-50.
17. Valentine MA, Meier KE, Rossie S, Clark EA. Phosphorylation of the CD20 phosphoprotein in resting B lymphocytes. J Biol Chem 1989;264:11282-87.
18. Clark EA, Shu G, Ledbetter JA. Role of the Bp35 cell surface polypeptide in human B cell activation. Proc Natl Acad Sci USA 1985;82:1766-70.
19. Clark EA, Shu G. Activation of human B cell proliferation through surface Bp35 (CD20) polypeptides or immunoglobulin receptors. J Immunol 1987;138:720-5.
20. 1 phase of the cell cycle. J Immunol 1985;135:3795-801.
21. Smeland E, Godal T, Ruud E, et al. The specific induction of myc protooncogene expression in normal human B cells is not a sufficient event for acquisition of competence to proliferate. Proc Natl Acad Sci USA 1985;82:6255-9.
22. Rabinovitch PS, Clark EA, Pezzutto A, Ledbetter JA, Draves KE. Modulation of human B-cell activation with Workshop monoclonal antibodies to B-cell associated differentiation antigens In: McMichael AJ, ed. Leukocyte typing III. White cell differentiation antigens. Oxford: Oxford University Press, 1987:435-9.
23. White MW, Shu GL, Draves KE, Morris DR, Clark EA. Surface IgM and CD20 receptors utilize distinct signal transduction pathways. In: Knapp W, Dörken B, Gilks WR, et al, eds. Leucocyte typing IV. White cell differentiation antigens. Oxford: Oxford University Press, 1989:54.
24. Clark EA, Shu GL, Luscher B, et al. Activation of human B cells. Comparison of the signal transduced by IL-4 to four different competence signals. J Immunol 1989;143:3873.
25. Tedder TF, Forsgren A, Boyd AW, Nadler LM, Schlossman SF. Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes. Eur J Immunol 1986;16:881-7.
26. Valentine MA, Licciardi KA, Clark EA, Krebs EG, Meier KE. Insulin regulates serine/threonine phosphorylation in human B lymphocytes. J Immunol 1993;150:96-105.
27. Valentine MA, Cotner T, Gaur L, Torres R, Clark EA. Expression of the human B-cell surface protein CD20: alteration by phorbol 12-myristate 13-acetate. Proc Natl Acad Sci USA 1987;84:8085-9.
28. Tedder TF, Zhou LJ, Bell PD, Frizell RA, Bubien JK. The CD20 surface molecule of B lymphocytes function as a calcium channel. J Cell Biochem 1990;14D:195-205.
29. Bubien JK, Bell PD, Frizzell RA, Tedder TF. CD20 directly regulates transmembrane ion flux in B-lymphocytes. In: Knapp W, Dörken B, Gilks WR, et al, eds. Leucocyte typing IV. White cell differentiation antigens. Oxford: Oxford University Press, 1989:51-4.
30. +2 conductance found constitutively in B lymphocytes. J Cell Biol 1993;121:1121-32.
31. Bourget I, Di Berardino W, Breittmayer J-P, et al. CD20 monoclonal antibodies stimulate extracellular cleavage of the low affinity receptor for IgE (FcεRII/CD23) in Epstein-Barr-transformed B cells. J Biol Chem 1994;269:6927-30.
32. Stafford AN, Rider SH, Hopkin JM, Cookson WO, Monaco AP. A 2.8 Mb YAC contiq in 11q12-q13 localizes candidate genes for atopy: Fc epsilon RI beta and CD20. Hum Mol Gen 1994;3:779-85.
33. Deans JP, Kalt L, Ledbetter JA, Schieven GL, Bolen JB, Johnson P. Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20. J Biol Chem 1995;270:22632-8.
34. Danescu M, Wu C, Rubio M, Delespesse G, Sarfati M. IL-4 induces conformational change of CD20 antigen via a protein kinase C-independent pathway. Antagonistic effect of anti-CD40 monoclonal antibody. J Immunol 1992;148: 2411-8.
35. Bourget I, Breittmayer J-P, Grenier-Brossette, Cousin J-L. CD20 monoclonal antibodies down-regulate IgM at the surface of B cells. Eur J Immunol 1993;23:768-71.
36. Pandrau D, Saeland S, Duvert V, et al. Interleukin 4 inhibits in vitro proliferation of leukemic and normal human B cell precursors. J Clin Invest 1992;90:1697-706.
37. Ohyashiki K, Miyauchi J, Ohyashiki JH, et al. Interleukin-7 enhances colony growth and induces CD20 antigen of a Ph+ acute lymphoblastic leukemia cell line, OM9;22. Leukemia 1993;7:1034-40.
38. Moreau I, Duvert V, Banchereau J, Saeland S. Culture of human fetal blood B-cell precursors on bone marrow stroma maintains highly proliferative CD20 dim cells. Blood 1993;81:1170-8.
39. Nadler LM, Korsmeyer SF, Anderson KC, et al. B cell origin of non-T-cell acute lymphoblastic leukemia: A model for discrete stages of neoplastic and normal pre-B cell differentiation. J Clin Invest 1984;74:332-40.
40. Hokland P, Ritz J, Schlossman SF, Nadler LM. Orderly expression of B cell antigens during the in vitro differentiation of non-malignant human pre-B cells. J Immunol 1985; 135:1746-51.
41. + B-cell precursors by an anti-CD19 pan-B-cell immunotoxin containing pokeweed antiviral protein. Blood 1992;79:3369-79.
42. dim cells. Blood 1993;81: 1170-8.
43. Stashenko P, Nadler LM, Hardy R, Schlossman SF. Expression of cell surface markers after human B lymphocyte activation. Proc Natl Acad Sci USA 1981;78:3848-52.
44. Boyd A, Freedman AS, Anderson KC, et al. Phenotypic changes occurring during in vitro activation of human splenic B lymphocytes. In: Reinherz EL, Haynes BF, Nadler LM, Bernstein ID, eds. Leukocyte typing II. Berlin: Springer Verlag, 1986:429-42.
45. Hutlin LE, Hausner MA, Hutlin PM, Giorgi JV. CD20 (pan-B cell) antigen is expressed at a low level on a subpopulation of human T lymphocytes. Cytometry 1993;14: 196-204.
46. O'Donnell LR, Alder SL, Balis UJ, Perkins SL, Kjeldsberg CR. Immunohistochemical reference ranges for B lymphocytes in bone marrow biopsy paraffin sections. Am J Clin Pathol 1995;104:517-23.
47. Shin SS, Sheibani K, Kezirian J, et al. Immunoarchitecture of normal human bone marrow: a study of frozen and fixed tissue sections. Hum Pathol 1992;23:686-94.
48. + T-cell lymphoma. Neoplastic transformation of a normal T-cell subset. Am J Clin Pathol 1994;102: 483-9.
49. Fend F, Nachbaur D, Oberwasserlechner F, Kreczy A, Huber H, Müller-Hermelink HK. Phenotype and topography of human thymic B cells. An immunohistologic study. Virch Arch B Cell Pathol 1991;60:381-8.
50. Cerroni L, Smolle J, Soyer HP, Aparicio AM, Kerl H. Immunophenotyping of cutaneous lymphoid infiltrates in frozen and paraffin-embedded tissue sections: a comparative study. J Am Acad Dermatol 1990;22:405-13.
51. Xu H, Friedrichs U, Gieseler RKH, Ruppert J, Ocklind G, Peters JH. Human blood dendritic cells exhibit a distinct T-cell-stimulating mechanism and differentiation pattern. Scand J Immunol 1992;36:689-96.
52. Moldenhauer G, Dorken B, Schwartz R, Pezzutto A, Knops J, Hammerling G. In: Reinherz EL, Haynes BF, Nadler LM, Bernstein ID, eds. Leukocyte typing, vol. 2. New York: Springer Verlag, 1986:61-67.
53. Staal FJT, Roederer M, Bubp J, et al. CD20 expression is increased on B lymphocytes from HIV-infected individuals. J AIDS 1992;5:627-32.
54. Lane HC, Depper JM, Greene WC, Fauci AS. Qualitative analysis of immune function in patients with AIDS. Evidence for a selective defect in soluble antigen recognition. N Engl J Med 1985;313:79-83.
55. Nadler LM, Ritz J, Hardy R, Pesando JM, Schlossman SF. A unique cell surface antigen identifying lymphoid malignancies of B cell origin. J Clin Invest 1981;67:134-40.
56. Dobson CM, Myskow MW, Krajewski AS, Carpenter FH, Horne CHW. Immunohistochemical staining of non-Hodgkin's lymphoma in paraffin sections using the MB1 and MT1 monoclonal antibodies. J Pathol 1987;153:203-12.
57. Hall PA, D'Ardenne AJ, Richards MA, Stansfeld G. Lymphoplasmacytoid lymphoma: an immunohistological study. J Pathol 1987;153:213-23.
58. Hall PA, D'Ardenne AJ, Stansfeld G. Paraffin section immunohistochemistry. I. Non-Hodgkin's lymphoma. Histopathology 1988;13:149-60.
59. Hall PA, D'Ardenne AJ, Stansfeld AG. Paraffin section immunohistochemistry. II. Hodgkin's disease and large cell anaplastic (Ki1) lymphoma. Histology 1988;13:161-169.
60. Hansmann M-L, Fellbaum C, Bohm A. Large cell anaplastic lymphoma: evaluation of immunophenotype on paraffin and frozen sections in comparison with ultrastructural features. Virch Arch A Pathol Anat 1991;418:427-33.
61. +) lymphomas. Virch Arch A Pathol Anat 1992;420:527-32.
62. Macon WR, Williams ME, Greer JP, Stein RS, Collins RD, Cousar JB. T-cell-rich B-cell lymphomas. A clinicopathologic study of 19 cases. Am J Surg Pathol 1992;16:351-63.
63. Kurtin PJ, Roche PC. Immunoperoxidase staining on non-Hodgkin's lymphomas for T-cell lineage associated antigens in paraffin sections. Comparison of the performance characteristics of four commercially available antibody preparations. Am J Surg Pathol 1993;17:898-904.
64. Chadburn A, Knowles DM. Paraffin-resistant antigens detectable by antibodies L26 and polyclonal CD3 predict the B- or T-cell lineage of 95% of diffuse aggressive non-Hodgkin's lymphomas. Am J Clin Pathol 1994;102:284-91.
65. Picker LJ, Weiss LM, Medeiros LJ, Wood GS, Warnke RA. Immunophenotypic criteria for the diagnosis of non-Hodgkin's lymphoma. Am J Pathol 1987;128:181-201.
66. Norton AJ, Isaacson PG. Lymphoma phenotyping in formalin-fixed and paraffin wax-embedded tissues: II. Profiles of reactivity in the various tumour types. Histopathology 1989;14:557-79.
67. Contos MJ, Dornstein MJ, Innes DJ, Ben-Ezra J. The utility of CD20 and CD43 in subclassification of low-grade B-cell lymphoma on paraffin sections. Mod Pathol 1992;5:631-3.
68. Dorfman DM, Pinkus GS. Distinction between small lymphocytic and mantle cell lymphoma by immunoreactivity for CD23. Mod Pathol 1994;7:326-31.
69. Cossman J, Neckers LM, Hsu S-M, Longo D, Jaffe ES. Low-grade lymphomas. Expression of developmentally regulated B-cell antigens. Am J Pathol 1984;115:117-24.
70. Marti GE, Zenger V, Caproaso NE, et al. Antigenic expression of B-cell chronic lymphocytic leukemic lymphocytes. Anal Quant Cytol Histol 1989;11:315-23.
71. Geisler CH, Larsen JK, Hansen NE, et al. Prognostic importance of flow cytometric immunophenotyping of 540 consecutive patients with B-cell chronic lymphocytic leukemia. Blood 1991;78:1795-802.
72. Almasri NM, Duque RE, Iturraspe J, Everett E, Braylan RC. Reduced expression of CD20 antigen as a characteristic marker for chronic lymphocytic leukemia. Am J Hematol 1992;40:259-63.
73. Witzig TE, Li C-Y, Tefferi A, Katzmann JA. Measurement of the intensity of cell surface antigen expression in B-cell chronic lymphocytic leukemia. Am J Clin Pathol 1994;101: 312-7.
74. Bluth RF, Casey TT, McCurley TL. Differentiation of reactive from neoplastic small-cell lymphoid aggregates in paraffin-embedded marrow particle preparations using L-26 (CD20) and UCHL-1 (CD45RO) monoclonal antibodies. Am J Clin Pathol 1993;99:150-6.
75. Genot E, Valentine MA, Degos L, Sigaux F, Kolb JP. Hyperphosphorylation of CD20 in hairy cells. Alteration by low molecular weight B cell growth factor and IFN-a. J Immunol 1991;146:870-8.
76. Robbins BA, Ellison DJ, Spinosa JC, et al. Diagnostic application of two-color flow cytometry in 161 cases of hairy cell leukemia. Blood 1993;82:1277-87.
77. Juliusson G, Lenkel R, Liliemark J. Flow cytometry of blood and bone marrow cells from patients with hairy cell leukemia: phenotype of hairy cells and lymphocyte subsets after treatment with 2-chlorodeoxyadenosine. Blood 1994; 83:3672-81.
78. Arber DA, Weiss LM. CD43: a review. Appl Immunohistochem 1993;1:88-96.
79. Weiss LM, Arber DA, Chang KL. CD45: a review. Appl Immunohistochem 1993;1:166-81.
80. Mason DY, Cordell JL, Tse ABD, et al. The Ig M-associated protein mb-1 as a marker of normal and neoplastic B cells. J Immunol 1991;147:2474-82.
81. Mason DY, van Noesel CJM, Cordell JL, et al. The B29 and mb-1 polypeptides are differentially expressed during human B-cell differentiation. Eur J Immunol 1992;22: 2753-6.
82. Anderson KC, Bates MP, Slaughenhoupt BL, Pinkus GS, Schlossman SF, Nadler LM. Expression of human B cell-associated antigens on leukemias and lymphomas: a model of human B cell differentiation. Blood 1984;63:1424-33.
83. Foon KA, Todd RF. Immunologic classification of leukemia and lymphoma. Blood 1986;68:1-31.
84. Picozzi VJ, Coleman CN. Lymphoblastic lymphoma. Semin Oncol 1990;17:96-103.
85. Warzynski MJ, Graham DM, Axtell RA, Zakem MH, Rotman RK. Low level CD20 expression on T cell malignancies. Cytometry 1994;18:88-92.
86. Chu W-S, Abbondanzo SL, Frizzera G. Inconsistency of the immunophenotype of Reed-Sternberg cells in simultaneous and consecutive specimens from the same patients. A paraffin section evaluation in 56 patients. Am J Pathol 1992;141:11-7.
87. Agnarsson B, Kadin ME. The immunophenotype of Reed-Sternberg cells. A study of 50 cases of Hodgkin's disease using fixed frozen tissues. Cancer 1989;63:2083-7.
88. Enblad G, Sundström C, Glimelius B. Immunohistochemical characteristics of Hodgkin and Reed-Sternberg cells in relation to age and clinical outcome. Histopathology 1993; 22:535-41.
89. Strauchen JA, Dimitriu-Bona A. Immunopathology of Hodgkin's disease. Characterization of Reed-Sternberg cells with monoclonal antibodies. Am J Pathol 1986;123: 293-300.
90. Pinkus GS, Said JW. Hodgkin's disease, lymphocyte predominance type, nodular - a distinct entity? Unique staining profile for L&H variants of Reed-Sternberg cells defined by monoclonal antibodies to leukocyte common antigen, granulocyte-specific antigen, and B-cell-specific antigen. Am J Pathol 1985;118:1-6.
91. Pinkus GS, Said JW. Hodgkin's disease, lymphocyte predominance type, nodular - further evidence for a B cell derivation. L&H variants of Reed-Sternberg cells express L26, a pan B cell marker. Am J Pathol 1988;133:211-7.
92. Coles FB, Cartun RW, Pastuszak WT. Hodgkin's disease, lymphocyte-predominant type: immunoreactivity with B-cell antibodies. Mod Pathol 1988;1:274-8.
93. Schmid C, Pan L, Diss T, Isaacson PG. Expression of B-cell antigens by Hodgkin's and Reed-Sternberg cells. Am J Pathol 1991;139:701-7.
94. Zukerberg LR, Collins AB, Ferry JA, Harris NL. Coexpression of CD15 and CD20 by Reed-Sternberg cells in Hodgkin's disease. Am J Pathol 1991;139:475-83.
95. Bai MC, Jiwa NM, Horstman A, et al. Decreased expression of cellular markers in Epstein-Barr virus-positive Hodgkin's disease. J Pathol 1994;174:49-55.
96. Tefferi A, Zellers RA, Banks PM, Therneau TM, Colgan JP. Clinical correlates of distinct immunophenotypic and histologic subcategories of lymphocyte-predominance Hodgkin's disease. J Clin Oncol 1990;8:1959-65.
97. Chittal SM, Alard C, Rossi R-F, et al. Further phenotypic evidence that nodular, lymphocyte-predominant Hodgkin's disease is a large B-cell lymphoma in evolution. Am J Surg Pathol 1990;14:1024-35.
98. Stoler MH, Nichols GE, Symbula M, Weiss LM. Lymphocyte predominance Hodgkin's disease. Evidence for a κ light chain-restricted monotypic B-cell neoplasm. Am J Pathol 1995;146:812-8.
99. Timens W, Visser L, Poppema S. Nodular lymphocyte predominance type of Hodgkin's disease is a germinal center lymphoma. Lab Invest 1986;54:457-61.
100. Poppema S, Kaiserling E, Lennert K. Nodular paragranuloma and progressively transformed germinal centers. Ultrastructural and immunohistologic findings. Virch Arch Cell Pathol 1979;31:211-25.
101. Momose H, Chen Y-Y, Ben-Ezra J, Weiss LM. Nodular lymphocyte predominant Hodgkin's disease: study of immunoglobulin light chain protein and mRNA expression. Hum Pathol 1992;23:1115-9.
102. Nicholas DS, Harris S, Wright DH. Lymphocyte predominance Hodgkin's disease - an immunohistochemical study. Histopathology 1990;16:157-5.
103. San Miguel JF, Gonzalez M, Gascón A, et al. Immunophenotypic heterogeneity of multiple myeloma: influence on the biology and clinical course of the disease. Br J Haematol 1991;77:185-90.
104. + is the common phenotype of myeloma cells. Ann Hematol 1992;64:132-9.
105. Harada H, Kawano MM, Huang N, et al. Phenotypic difference of normal plasma cells from mature myeloma cells. Blood 1993;81:2658-63.
106. Ruiz-Argüelles GJ, San Miguel JF. Cell surface markers in multiple myeloma. Mayo Clin Proc 1994;69:684-90.
107. Tienhaara A, Pilliniemi T-T. Peripheral blood B lymphocytes in multiple myeloma. Acta Haematol 1994;91:57-61.
108. Drexler H, Thiel E, Ludwig W-D. Acute myeloid leukemias expressing lymphoid-associated antigens: diagnostic incidence and prognostic significance. Leukemia 1993;7:489-98.
109. Chang KL, Weiss LM. CD7: a review. Appl Immunohistochem 1994;2:146-56.
110. Kita K, Nakase K, Miwa H, et al. Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality: frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34. Blood 1992;80:470-7.
111. Hanson CA, Abaza M, Sheldon S, Ross CW, Schnitzer B, Stoolman LM. Acute biphenotypic leukaemia: immunophenotypic and cytogenetic analysis. Br J Haematol 1993;84: 49-60.
112. Traweek ST. Immunophenotypic analysis of acute leukemia. Am J Clin Pathol 1993;99:504-512.
113. Traweek ST, Arber DA, Rappaport H, Byrnes RK. Extramedullary myeloid cell tumors. An immunohistochemical and morphologic study of 28 cases. Am J Surg Pathol 1993; 17:1011-9.
114. Hudock J, Chatten J, Miettinen M. Immunohistochemical evaluation of myeloid leukemia infiltrates (granulocytic sarcomas) in formaldehyde-fixed, paraffin-embedded tissue. Am J Clin Pathol 1994;102:55-60.
115. Bakshi A, Minowada J, Arnold A, et al. Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors. N Engl J Med 1983; 309:826-31.
116. Muehleck SD, McKenna RD, Arthur DC, Parkin JL, Brunning RD. Transformation of chronic myelogenous leukemia: clinical, morphologic, and cytogenetic features. Am J Clin Pathol 1984;82:1-14.
117. Vardiman JW. Chronic myelogenous leukemia and the myeloproliferative disorders. In: Knowles DM, ed. Neoplastic hematopathology. Baltimore: Williams and Wilkins, 1992:1413.
118. Torlakovic E, Litz CE, McClure JS, Brunning RD. Direct detection of the Philadelphia chromosome in CD20-positive lymphocytes in chronic myeloid leukemia by tri-color immunophenotyping/FISH. Leukemia 1994;8:1940-3.
119. Chilosi M, Castelli P, Martignoni G, et al. Neoplastic epithelial cells in a subset of human thymomas express the B cell-associated CD20 antigen. Am J Surg Pathol 1992;16: 988-97.
120. Marino M, Müller-Hermelink HK. Thymoma and thymic carcinoma: relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus. Virch Arch A 1985;407:119-49.
121. Battifora H, Alsabeh R, Jenkins KA, Gown A. Epitope retrieval (unmasking) in immunohistochemistry. Adv Pathol Lab Med (in press).
122. Press OW, Appelbaum F, Ledbetter JA, et al. Monoclonal antibody 1F5 (anti-CD20) serotherapy of human B cell lymphomas. Blood 1987;69:584-91.
123. 131I]anti-B1 (anti-CD20) antibody. N Engl J Med 1993;329:459-65.
124. Press OW, Eary JF, Appelbaum FR, et al. Radiolabeled-antibody therapy of B-cell lymphoma with autologous bone marrow support. N Engl J Med 1993;329:1219-24.
125. Press OW, Eary JF, Appelbaum FR, et al. Phase II trial of 131I-B1 (anti-CD20) antibody therapy with autologous stem cell transplantation for relapsed B cell lymphomas. Lancet 1995;346:336-40.
126. Maloney DG, Liles TM, Czerwinski DK, et al. Phase I Clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma. Blood 1994;84: 2457-66.