Frequent expression of the NPM-ALK chimeric fusion protein in anaplastic large-cell lymphoma, lympho-histiocytic type

American Journal of Pathology

Volumn 150, Issue 4, 1997, Pages 1207-1211

  Pileri, Stefane A ^a,f   Pulford, Karen ^b   Mori, Shigeo ^c   Mason, David Y ^b   Sabattini, Elena ^a   Roncador, Giovanna ^a   Piccioli, Milena ^a   Ceccarelli, Claudio ^a   Piccaluga, Pier Paolo ^a   Santini, Donatella ^a   Leone, Ornella ^a   Stein, Harald ^d   Falini, Brunangelo ^e  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF TOKYO   (Japan)

^d FREIE UNIVERSITÄT BERLIN   (Germany)

^e UNIVERSITY OF PERUGIA   (Italy)

^f UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; HYBRID PROTEIN;

ARTICLE; CANCER CLASSIFICATION; CANCER CYTODIAGNOSIS; CELL STRUCTURE; HUMAN; HUMAN CELL; LARGE CELL LYMPHOMA; PRIORITY JOURNAL; PROTEIN DETERMINATION; T CELL LYMPHOMA;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; HUMANS; LYMPHOMA, LARGE-CELL; LYMPHOMA, MIXED-CELL; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEIN-TYROSINE KINASES; TRANSLOCATION, GENETIC;

EID: 0030970804     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Stein H, Mason DY, Gerdes J, O'Connor N, Wainscoat J, Pallesen G, Gatter K, Falini B, Delsol G, Lemke H, Schwarting R, Lennert K: The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cell. Blood 1985, 66: 848-858
2. Agnarsson BA, Kadin ME: Ki-1 positive large cell lymphoma. Am J Surg Pathol 1988, 12:264-274
3. Chan JKC, Hui PK, Leungs TW, Lau WH, McGuire LJ: Anaplastic large cell Ki-1 lymphoma: delineation of 2 morphological types, Histopathology 1989, 11-34
4. Chott A, Kaserer K, Augustin I, Vasely M, Heinz R, Oehlinger W, Hanak H, Radaszkiewicz T: Ki-1 positive large cell lymphoma: a clinicopathologic study of 41 cases. Am J Surg Pathol 1990, 14:439-448
5. Stein H, Herbst H, Anagnostopoulos I, Niedobitek G, Dallenbach F, Kratzsch H-C: The nature of Hodgkin and Reed-Sternberg cells, their association with EBV, and their relationship to anaplastic large cell lymphoma. Ann Oncol 1991, 2:33-38
6. +): results of a prospective clinico-pathological study of 69 cases, Br J Haematol 1994, 86:513-523
7. Falini B, Pileri S, Pizzolo G, Flenghi L, Durkop H, Stirpe F, Martelli MF, Stein H: CD30 (KM) molecule: a new cytokine receptor of the TNF receptor superfamily as a target for diagnosis and immunotherapy. Blood 1995, 85:1-14
8. Pileri SA, Piccaluga A, Poggi S, Sabattini E, de Vivo A, Piccaluga PP, Falini B, Stein H: Anaplastic large cell iymphoma: update of findings. Leuk Lymphoma 1995, 18:17-25
9. +): clinical and prognostic evaluation of 90 adult patients, J Clin Oncol 1996, 14:955-962
10. Stansfeld AG, Diebold J, Kapanci Y, Kelenyi G, Lennert K, Mioduszewska O, Noel H, Rilke F, Sundstrom C, van Unnik JAM, Wright DH: Updated Kiel classification for lymphomas. Lancet 1988, i:292-293
11. Harris N, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KG, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Müller-Hermelink H-K, Pileri S, Piris MA, Ralfkiaer E, Warnke RA: A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994, 84: 1361-1392
12. + with a high content of reactive histiocytes). Histopathology 1990, 16:383-391
13. Kaneko Y, Frizzera G, Edamura S, Maseki N, Sakurai M, KomadaY, Sakurai M,Tanaka H, Sasaki M, SuchiT, Kikuta A, Wakasa H, Hojo H, Mizutani S: A novel translocation, t(2;5)(p23;q35), in large phagocytic large T-cell lymphoma mimicking malignant histiocytosis. Blood 1989, 73:806-813
14. +NHL). Blood 1988, 72:247A
15. RimokhR, Magaud JP, Berger F: A translocation involving a specific breakpoint (q35) on chromosome 5 is characteristic of anaplastic large cell lymphoma (KM lymphoma). Br J Haematol 1989, 71:31-36
16. Mason DY, Bastard C, Rimokh R, Dastugne N, Huret J-L, Kristoffersson V, Magaud J-P, Nezelof C, Tilly H, Vannier J-P, Hemet J, Warnke RA: CD30-positive large cell lymphomas ("Ki-1 lymphoma") are associated with a chromosomal translocation involving 5q35, Br J Haematol, 1990, 74:161-168
17. Morris SW, Kirstein MK, Valentine MB, Dittinen KG, Shapiro DK, Saltman DL, Look AT: Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 1994, 253: 1281-1284
18. Shiota M, Fujimoto J, Takenaga M, Satoh H, Ichinohasama R, Abe M, Nakano M, Yamamoto T, Mori S: Diagnosis of t(2;5)(p23;q35)-associated KM lymphoma with immunohistochemistry, Blood 1994, 84: 3648-3652
19. NPM/ALK: a distinct clinicopathologic entity. Blood 1995, 86:1954-1960
20. Pulford K, Lamant L, Morris S, Butler LH, Wood KM, Stroud D, Delsol G, Mason DY: Detection of ALK and NPM-ALK protein in normal and neoplastic cells with the monoclonal antibody ALK1. Blood 1997 (in press)
21. Bullrich F, Morris SW, Hummel M, Pileri S, Stein H, Croce CM: Nucleophosmin (NPM) gene rearrangement in Ki-1-positive lymphomas. Cancer Res 1994, 54:11:2873-2877
22. + lymphomas from American and Asian patients: a reverse transcriptase-polymerase chain reaction study. Am J Pathol 1995, 146:323-328
23. Herbst H, Anagnostopoulos J, Heinze B, Dürkop H, Hummel M, Stein H: ALK gene products in anaplastic large cell lymphomas and Hodgkin's disease. Blood 1995, 86:1694-1700
24. Cordell JL, Falini B, Erber WN, Ghosh AK, Abdulaziz Z, Macdonald S, Pulford KAF, Stein H, Mason DY: Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes), J Histochem Cytochem 1984, 32:219-229
25. Morgan JM. Navabi H, Schmid KW, Jasani B: Possible role of tissue-bound calcium ions in citrate-mediated high-temperature antigen retrieval. J Pathol 1994, 174: 301-307
26. Lennert K, Feller AC: Histopathology of non-Hodgkin's lymphomas (based on the updated Kiel classification), Berlin, Springer-Verlag, 1992, pp 256-258
27. Pileri S, Sabattini E, Poggi S, Amini M, Falini B, Stein H: Lympho-histiocytic T-cell lymphoma, Histopathology 1994, 25:191-193
28. + large B-cell lymphoma lacking t(2;5): a distinct immunomorphologic and genotypic subtype. VI Meeting of the International Lymphoma Study Group, Stanford, September 16-19, 1996