Genetic polymorphisms and new prospects in the prevention and treatment of obesity;Polimorfismos genéticos y nuevas perspectivas en la prevención y tratamiento de la obesidad

Nutricion Hospitalaria

Volumn 17, Issue SUPPL. 1, 2002, Pages 23-33

  Palou, Andreu ^a   Proenza, A M ^a   Ramis, J M ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

Genetic polymorphisms; Metabolism; Obesity in humans; Pathologies

Indexed keywords

ARTICLE; DNA POLYMORPHISM; ENERGY METABOLISM; FEEDING BEHAVIOR; GENE MUTATION; GENOTYPE; HUMAN; LIFESTYLE; OBESITY; PATHOGENESIS; PHENOTYPE; PREVALENCE;

HUMANS; OBESITY; PHENOTYPE; POLYMORPHISM, GENETIC;

EID: 0036195338     PISSN: 02121611     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (135)

1. Genetics of obesity: Overview and research directions
2. The search for human obesity genes
3. A major quantitative trait locus detemining serum leptin levels and fat mass is located on human chromosome 2
4. Genomewide search for genes influencing percent body fat in Pima Indians: Suggestive linkage at chromosome 11q21s22
5. Obesidad y alimentación: Nuevos genes de neuropéptidos orexígenos y anorexígenos en el SNC
6. Los genes de la obesidad
7. Genes de la obesidad. Nuevas claves en biología molecular
8. Obesity: Molecular bases of a multifactorial problem
9. Adipogenesis and obesity: Rounding out the big picture
10. Transcriptional activation of adipogenesis
11. In vivo modulation of hmgic reduces obesity
12. The uncoupling protein, thermogenin
13. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta3-adrenergic-receptor gene
14. Genetic variation in the beta3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity
15. Association of a polymorphism in the beta3-adrenergic-receptor gene with features of the insulin resistance syndrome in finns
16. Polymorphism of the beta3-adrenergic receptor gene in morbid obesity
17. Association of beta3-adrenergic receptor gene polymorphism with insulin resistance in Japanese-American men
18. A mutation in the beta3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects
19. A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans
20. Gender effect of the Trp64Arg mutation in the β3 adrenergic receptor gene on weight gain in morbid obesity
21. Effects of Trp64Arg mutation in the β3-adrenergic receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients
22. Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated with increased plasma leptin levels in obese Chinese women
23. Trp64Arg mutation of beta3-adrenoceptor gene deteriorates lipolysis induced by beta3-adrenoceptor agonist in human omental adipocytes
24. Phenotypic characterization of the beta3-adrenergic receptor mutation and the uncoupling protein 1 polymorphism in Japanese men
25. The association between Trp64Arg polymorphism of the beta3-adrenergic receptor and autonomic nervous system activity
26. Trp64Arg polymorphism of the beta3-adrenergic receptor gene in pregnancy: Association with mild gestational diabetes mellitus
27. Polymorphism of the beta3-adrenergic receptor gene and weight gain in pregnant diabetic women
28. Phenotypic characterization of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene in normal weight and obese subjects
29. Molecular scanning for mutations in the beta3-adrenergic receptor gene in Nauruans svith obesity and noninsulin-dependent Diabetes Mellitus
30. The Trp64Arg mutation of the beta3-adrenergic receptor gene has not effect on obesity phenotypes in the Québec family study and swedish obese subjects cohorts
31. The β3-adrenergic receptor Trp64Arg polymorphism and obesity in Alaskan Eskimos
32. The Trp64Arg polymorphism of the beta3-adrenergic receptor gene
33. Expression of the β3-adrenoceptor gene polymorphism (Trp64Arg) in obese diabetic and non-diabetic subjects
34. Lack of associations between serum leptin, a polymorphism in the gene for the β3-adrenergic receptor and glucose tolerance in the Dutch population
35. Absence of association between genetic variation of the beta3-adrenergic receptor and metabolic phenotypes in Oji-Cree
36. The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is not associated with obesity or type 2 Diabetes Mellitus in a large population-based caucasian cohort
37. The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients
38. Relation of beta3-adrenergic receptor gene mutation to total body fat but not percent body fat and insulin levels in Thais
39. Association of sets of alleles of genes encoding beta3-adrenoreceptor, uncoupling protein I and lipoprotein lipase with increased risk of metabolic complications in obesity
40. Human beta-2 adrenoreceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoreceptor function
41. The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females
42. The Gln27Glu beta2-adrenergic receptor variant is associated with obesity due to subcutaneous fat accumulation in Japanese men
43. Association of polymorphisms in the beta2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus
44. Lack of association between a human beta-2 adrenoceptor gene polymorphism (Gln27Glu) and morbid obesity
45. Polymorphism in the 5′-leader cistron of the beta2-adrenergic receptor gene associated xvith obesity and type 2 diabetes
46. Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects
47. DNA polymorphism in the uncoupling protein (UCP) gene and human body fat
48. Additive effect of A-G(-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta3-adrenergic receptor gene on weight gain in morbid obesity
49. Polymorphisms of uncoupling protein (UCP) and beta3 adrenoreceptor genes in obese people submitted to a low calorie diet
50. Studies of genetic variability of the uncoupling protein I gene in caucasian subjects with juvenile-onset obesity
51. DNA polymorphism in the uncoupling protein 1 (UCP1) gene has no effect on obesity related phenotypes in the Swedish obese subjects cohorts
52. Frequency and significance of the A → G (- 3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohort
53. Mutation screening of the human UCP2 gene in normoglycemic and NIDDM morbidly obese patients. Lack of association between new UCP2 polymorphisms and obesity in French Caucasians
54. Molecular screening of uncoupling protein 2 gene in patients with noninsulin-dependent diabetes mellitus or obesity
55. Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians
56. Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
57. Genomic organization and mutational analysis of the human UCP2 gene, a prime candidate gene for human obesity
58. Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene
59. Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24-h energy expenditure and substrate oxidation
60. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes
61. Human uncoupling proteins and obesity
62. Candidate gene approach of familial morbid obesity: Linkage analysis of the glucocorticoid receptor gene
63. Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Québec family study
64. Phenotypes in three pedigrees with autosomal dominant obesity caused by haploin-sufficiency mutations in the melanocortin-4 receptor gene
65. Functional characterization of mutations in melanocortin-4 receptor associated with human obesity
66. Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans
67. Identification and functional analysis of novel human melanocortin-4 receptor variants
68. Mutational analysis of the proopiomelanocortin gene in Caucasians with early onset obesity
69. Structure and sequence variation at the human leptin receptor gene in lean and obese Pima indians
70. The Gln223Arg and Lys656Asn polymorphisms in the human leptin receptor do not associate with traits related to obesity
71. A common pentanucleotide polymorphism of the 3′-untranslated part of the leptin receptor gene generates a putative stem-loop motif in the mRNA and is associated with serum insulin levels in obese individuals
72. Leptin receptor gene in a large cohort of massively obese subjects: No indication of hte fa/fa rat mutation. Detection of an intronic variant with no association wtih obesity
73. Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Quebec Family Study
74. Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7
75. Meta-analysis of linkage data under worst-case conditions: A demonstration using the human OB region
76. Neuropeptide Y: A novel link between the neuroendocrine system and cholesterol metabolism
77. Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels
78. Gene structure of human cholecystokinin (CCK) type-A receptor: Body fat content is related to CCK type-A receptor gene promoter polymorphism
79. Single base polymorphism in the human tumour necrosis factor alpha (TNF-α) gene detectable by NcoI restriction of PCR product
80. Polymorphisms of the tumour necrosis factor-α gene, coronary heart disease and obesity
81. Excessive fat accumulation is associated with the TNF alpha-308 G/A promoter polymorphism in women but not in men
82. Tumor necrosis factor-alpha-238 and - 308 polymorphisms do not associated with traits related to obesity and insulin resistance
83. A common functional polymorphism (C → A substitution at position - 863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha
84. The dopamine D2 receptor (DRD2) as a major gene in obesity and height
85. Increased prevalence of the Taq I A1 allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: A preliminary report
86. D2 dopamine receptor gene and obesity
87. Polymorphisms of the D2 dopamine receptor gene and alcoholism and other substance use disorders
88. DRD2 gene and alcoholism
89. A genetic polymorphism of the peroxisome proliferator-activated receptor γ gene influences plasma leptin levels in obese humans
90. Peroxisome proliferator-activated receptor gamma C161 → T polymorphism and coronary artery disease
91. The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects
92. Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-gamma2 (PPAR-gamma2): Divergent modulating effects on body mass index in obese and lean Caucasian men
93. Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women
94. DNA polymorphisms at the lipoprotein lipase gene and their association with quantitative variation in plasma high-density lipoproteins and triacylglycerides
95. Lipoprotein lipase gene polymorphisms: Associations with hypertriglyceridemia and body mass index in obese people
96. The lipoprotein lipase HindIII polymorphism modulates plasma triglyceride levels in visceral obesity
97. Two DNA polymorphisms in the lipoprotein lipase gene and their associations with factors related to cardiovascular disease
98. Polymorphisms in the lipoprotein lipase gene and their associations with plasma lipid concentrations in 40-year-old danish men
99. Common DNA polymorphisms at the lipoprotein lipase gene. Association with severity of coronary artery disease and diabetes
100. Association of DNA-halotypes in the human LDL-receptor gene with normal serum cholesterol levels
101. Variation in the low density lipoprotein receptor gene is associated with differences in plasma low density lipoprotein cholesterol levels in young and old normal individuals from Italy
102. Normal DNA polymorphism at the low density lipoprotein receptor (LDLR) locus associated with serum cholesterol level
103. Detection of the low density lipoprotein receptor gene PvuII intron 15 polymorphism using the polymerase chain reaction: Association with plasma lipid traits in healthy men and women
104. Effect of the Stul polymorphism in the LDL receptor gene (Ala370 to Thr) on lipid levels in healthy individuals
105. Ionizing radiation and genetic risks. VI. Chronic multifactorial diseases a review of epidemiological and genetical aspects of coronary heart disease, essential hypertension and diabetes mellitus
106. Association of DNA polymorphism at the apolipoprotein B gene locus with coronary heart disease and serum very low density lipoprotein levels
107. Relationship of two apolipoprotein B polymorphisms with serum lipoprotein and lipid levels in african blacks
108. Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men: An autopsy study
109. Plasma leptin levels. Interaction of obesity with a common variant of insulin receptor substrate-1
110. Linkage of chromosomal markers on 4q with a putative gene determining maximal insulin action in Pima Indians
111. Common genomic variants associated with variation in plasma lipoproteins in young aboriginal Canadians
112. Variation of the fatty acid binding protein 2 gene is not associated with obesity and insulin resistance in Japanese subjects
113. Associations of IGF2 Apal RFLP and INS VNTR class I allele size with obesity
114. Contribution of the cholesteryl ester transfer protein gene TaqIB polymorphism to the reduced plasma HDL-cholesterol levels found in abdominal obese men with the features of the insulin resistance syndrome
115. A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women
116. A paired-sibling analysis of the Xbal polymorphism in the muscle glycogen synthase gene
117. A novel promoter variant of the natriuretic peptide clearance receptor gene is associated with lower atrial natriuretic peptide and higher blood pressure in obese hypertensives
118. Retinoic acid modulates retinoid X receptor alpha and retinoic acid receptor alpha levels of cultured brown adipocytes
119. In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid
120. Obesity and mortality: A review of the epidemiologic data
121. Energy restriction with high-fat diet enriched with coconut oil gives higher UCP1 and lower white fat in rats
122. A review of long-term studies evaluating the efficacy of weight loss in ameliorating disorders associated with obesity
123. Stimulation of uncoupling protein 1 expression in brown adipocytes by naturally occurring carotenoids
124. Deoxyribonucleic acid binding and transcriptional silencing by a truncated c-erbA beta 1 thyroid hormone receptor identified in a severely retarded patient with resistance to thyroid hormone
125. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
126. Congenital leptin deficiency is associated with severe early-onset obesity in humans
127. A leptin missense mutation associated with hypogonadism and morbid obesity
128. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
129. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
130. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
131. A frameshift mutation in MC4R associated with dominantly inherited human obesity
132. A frameshift mutation in human MC4R is associated with a dominant form of obesity
133. The human obesity gene map: The 1998 update