Energy restriction with high-fat diet enriched with coconut oil gives higher UCP1 and lower white fat in rats

International Journal of Obesity

Volumn 22, Issue 10, 1998, Pages 974-979

  Portillo, M P ^a   Serra, F ^b   Simon, E ^a   Del Barrio, A S ^a   Palou, A ^b  

^a Nutrition and Food Science   (Spain)

^b UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

Brown adipose tissue; Dietary fat; Energy restriction; Obesity; UCP1

Indexed keywords

COCONUT OIL; UNCOUPLING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY WEIGHT; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CONTROLLED STUDY; DIET RESTRICTION; DOWN REGULATION; FEMALE; FOOD INTAKE; IMMUNOBLOTTING; LIPID COMPOSITION; LIPID DIET; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

EID: 0031705725     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800706     Document Type: Article

References (28)

1. Rothwell NH, Stock MJ. Brown adipose tissue and diet-induced thermogenesis. In: Trayhurn P, Nicholls DG (eds). Brown adipose tissue. Edward Arnold: London, 1986; pp 269-298.
2. Trayhurn P. Brown adipose tissue and energy balance. In: Trayhurn P, Nicholls DG (eds). Brown adipose tissue. Edward Arnold: London, 1986; pp 299-338.
3. Himms-Hagen J. Brown adipose tissue in cold acclimation. In: Trayhurn P, Nicholls DG (eds). Brown adipose tissue. Edward Arnold: London, 1986; pp 214-268.
4. Nicholls DG, Locke R. Thermogenic mechanisms in brown fat. Physiol Rev 1984; 64: 1-64.
5. Palou A, Picó C, Bonet ML, Oliver P. Molecules in the focus: the uncoupling protein (UCP) thermogenin. Int J Biochem Cell Biol 1998; 30: 7-11.
6. Bukowiecki LJ. Regulation of diet-induced thermogenesis in brown adipose tissue. In: Bray GA (ed). Diet and Obesity. Karger: Basel, 1988; pp 71-85.
7. Himms-Hagen J. Brown adipose tissue thermogenesis and obesity. Prog Lipid Res 1989; 28: 67-115.
8. Rothwell NJ, Stock MJ, Warwick BP. Energy balance and brown fat activity in rats fed cafeteria diets or high-fat semisynthetic diets at several levels of intake. Metabolism 1983; 34: 474-480.
9. Glick Z, Wickler SJ, Stern JS, Horwitz BA. Blood flow into brown fat is greater after a high carbohydrate than after a high fat test meal. J Nutr 1984; 114: 1934-1939.
10. Mercer SW, Trayhurn P. Effects of high fat diets on energy balance and thermogenesis in brown adipose tissue of lean and genetically obese ob/ob mice. J Nutr 1987; 117: 227-231.
11. Puigserver P, Lladó I, Palou A, Gianotti M. Evidence for masking of brown adipose tissue mitochondrial GDP-binding sites in response to fasting in rats made obese by dietary manipulation. Biochem J 1991; 279: 575-579.
12. Matamala JC, Gianotti M, Pericàs J, Quevedo S, Roca P, Palou A, García-Palmer FJ. Changes induced by fasting and dietetic obesity in thermogenic parameters of rat brown adipose tissue mitochondrial subpopulations. Biochem J 1996; 319: 529-534.
13. Sadurskis A, Dicker A, Cannon B, Nedergaard J. Polyunsaturated fatty acids recruit brown adipose tissue: increased UCP content and NST capacity. Am J Physiol 1995; 269: E351-E360.
14. Mercer SW, Trayhurn P. Effect of high fat diets on thermogenic activity of brown adipose tissue in cold-acclimated mice. J Nutr 1984; 114: 1151-1158.
15. Bradford MM. A rapid and sensitive method for the quantitation of microgram of protein utilizing the principle of protein dye binding. Anal Biochem 1976; 72: 248-257.
16. Herron D, Rehnmark S, Méchand M, Loncar D, Cannon B, Nedergaard J. Norepinephrine-induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture. FEBS Lett 1990; 268: 296-300.
17. Puigserver P, Herron D, Gianotti M, Palou P, Cannon B, Nedergaard J. Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in-vitro and in-vivo: evidence for a rapidly degradable pool. Biochem J 1992; 284: 393-398.
18. Puigserver P, Vázquez F, Bonet ML, Picó C, Palou A. In vitro and in vivo induction of brown adipocyte uncoupling protein (thermogenin) by retinoic acid. Biochem J 1996; 317: 827-833.
19. Laemmli VK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685.
20. Sclafani A. Diet-induced obesity in rodents. In: Oomura Y, Tarvi S, Inove S, Shimazu T (eds). Progress in Obesity Research. John Libbey: London, 1991; pp 441-444.
21. Sclafani A. Dietary obesity models. In: Bjömtorp, P, Brodoff BN (eds). Obesity. Lippincott JB: London, 1991; pp 241-248.
22. Picó C, Pons A, Gianotti M, Palou A. Sustained changes in blood alpha amino nitrogen compartmentation during recovery from cafeteria feeding in rats. Arch Intern Physiol Biochim Biophys 1991; 99: 345-348.
23. Rothwell NJ, Stock MJ. Stimulation of thermogenesis and brown fat activity in rats fed medium chain triglyceride. Metabolism 1987; 36: 128-130.
24. Rothwell NJ, Stock MJ, Tyzbir RS. Energy balance and mitochondrial function in liver and brown fat of rats fed cafeteria diets of varying protein content. J Nutr 1982; 112: 1663-1672.
25. Gianotti M, Clapés J, Lladó I, Palou A. Effect of 12, 24 and 72 hours fasting in thermogenic parameters of rat BAT mitochondrial subpopulations. Life Science 1998; 62: 1889-1899.
26. Champigny O, Ricquier D. Effects of fasting and refeeding on the level of uncoupling protein mRNA in rat brown adipose tissue: evidence for diet-induced and cold-induced responses. J Nutr 1990; 120: 1730-1736.
27. Young JB, Walgren MC. Differential effects of dietary fats on sympathetic nervous system activity in the rat. Metabolism 1994; 43: 51-60
28. Dulloo AG, Mensi N, Seydoux J, Girardier L. Differential effects of high-fat diets varying in fatty acid composition on the efficiency of lean and fat tissue deposition during weight recovery after low food intake. Metabolism 1995; 44: 273-279.