Plasma leptin levels: Interaction of obesity with a common variant of insulin receptor substrate-1

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 11, 1998, Pages 1686-1690

  Krempler, Franz ^a   Hell, Emanuel ^a   Winkler, Carmen ^b   Breban, David ^b   Patsch, Wolfgang ^b  

^a Krankenhaus Hallein   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Insulin receptor substrate 1; Insulin resistance; Leptin; Obesity

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 1; LEPTIN;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CODON; DISEASE ASSOCIATION; FEMALE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION;

EID: 0031743490     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.11.1686     Document Type: Article

References (15)

1. Pyörälä K. Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes Care. 1979;2:131-141.
2. Welborn TA, Wearne K. Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentrations. Diabetes Care. 1979;2:154-160.
3. Després JP, Lamarche B, Mauriège P, Cantin B, Dagenais GR, Moorjani S, Lupien PJ. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med. 1996;334:952-957.
4. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-432.
5. Chen H, Charlat O, Tartaglia LA, Woolf EA, Wenig X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 1996;84:491-495.
6. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chatt BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995;269:543-546.
7. Considine RV, Considine EL, Williams CJ, Hyde TM, Caro JF. The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes. 1996;45:992-994.
8. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winter D, Boone T, Collins F. Effect of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540-543.
9. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269:546-549.
10. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D, Woods SC, Seeley RJ, Weigle DS. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes. 1996;45:531-535.
11. Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature. 1997;389:374-377.
12. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J. Transient increase in obese gene expression after food intake and insulin administration. Nature. 1995;377:527-529.
13. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens ThW, Nyce M, Ohannesian JP, Cheryl C, Marco RD, Linda J, McKee MHS, Bauer ThL, Caro JF. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292-295.
14. Malmstrom R, Taskinen MR, Karonen SL, Ykijarvinen H. Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia. 1996;39:993-996.
15. Vidal H, Auboeuf D, De Vos P, Staels B, Riou JP, Auwerx J, Laville M. The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue. J Clin Invest. 1996;98:251-255.