A common pentanucleotide polymorphism of the 3'-untranslated part of the leptin receptor gene generates a putative stem-loop motif in the mRNA and is associated with serum insulin levels in obese individuals

International Journal of Obesity

Volumn 22, Issue 7, 1998, Pages 634-640

  Oksanen, L ^a   Kaprio, J ^a   Mustajoki, P ^b   Kontula, K ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b PEIJAS HOSPITAL   (Finland)

Author keywords

Insulin; Leptin receptor; mRNA; Obesity

Indexed keywords

GLUCOSE; INSULIN; LEPTIN RECEPTOR; LIPID; MESSENGER RNA; RESTRICTION ENDONUCLEASE;

ADULT; ARTICLE; BLOOD LEVEL; BODY MASS; DNA DETERMINATION; DNA POLYMORPHISM; FEMALE; GENE SEQUENCE; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0031809291     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800639     Document Type: Article

References (39)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432.
2. Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet 1996; 12: 318-320.
3. Tartaglia LA, Dembski M, Weng Z, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wolf EA, Monroe CA, Tepper RI. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83: 1263-1271.
4. Cioffi JA, Shafer AW, Zupancic TJ, Smith-Gbur J, Mikhail A, Platika D, Snodgrass HR. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nature Med 1996; 2: 585-589.
5. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RJ, Morgenstern JP. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84: 491-495.
6. Chua Jr SC, Chung WK, Sharon WP, Yiying Z, Liu SM, Tartaglia L, Leibel RL. Phenotypes of mouse diabetes and rat fatty due to mutations in the ob (leptin) receptor. Science 1996; 271: 994-996.
7. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-635.
8. Takaya K, Ogawa Y, Hiraoka J, Hosoda K, Yamori Y, Nakao K, Koletsky RJ. Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat. Nature Genet 1996; 14: 130-131.
9. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903-908.
10. Kishimoto T, Taga T, Akira S. Cytokine signal transduction. Cell 1994; 76: 253-262.
11. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-295.
12. Hamilton BS, Paglia D, Kwan AYM, Deitel M. Increased obese mRNA expression in omental fat cells from massively obese humans. Nature Med 1995; 1: 953-956.
13. Lönnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Med 1995; 1: 950-953.
14. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med 1995; 1: 1155-1161.
15. Considine RV, Considine EL, Williams CJ, Hyde TM, Caro JF. The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 1996; 45: 992-994.
16. Thompson DB, Ravussin E, Bennett PH, Bogardus C. Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians. Hum Mol Gen 1997; 6: 675-679.
17. Echwald SM, Sorensen TD, Sorensen TI, Tybjærg-Hansen A, Andersen T, Chung WK, Leibel RL, Pedersen O. Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity. Biochem Biophys Res Commun 1997; 233: 248-252.
18. Gotoda T, Manning BS, Goldstone AP, Imrie H, Evans AL, Strosberg AD, McKeigue PM, Scott J, Aitman TJ. Leptin receptor gene variation and obesity: lack of association in a white British male population. Hum Mol Gen 1997; 6: 869-876.
19. Chung WK, Power-Kehoe L, Chua M, Chu F, Aronne L, Huma Z, Sothern M, L'dall JN, Kahle B, Leibel RL. Exonic and intronic sequence variation in the human leptin receptor gene (LEPR). Diabetes 1997; 46: 1509-1511.
20. Francke S, Clément K, Dina C, Inoue H, Behn P, Vatin V, Basdevant A, Guy-Grand B, Permutt MA, Froguel P, Hager J. Genetic studies of the leptin receptor gene in morbidly obese French Caucasian families. Hum Genet 1997; 100: 491-496.
21. 3-adrenergic receptor gene in morbid obesity. Int J Obes 1996; 20: 1055-1061.
22. Chung WK, Power-Kehoe L, Chua M, Lee R, Leibel RL. Genomic structure of the human OB receptor and identification of two novel intronic microsatellites. Genome Res 1996; 6: 1192-1199.
23. Orita M, Suzuki T, Sekiya T. Hayashi K. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 1989; 5: 874-879.
24. Sanger F, Nicklen S, Coulson AR, DNA sequencing with chain inhibiting inhibitors. Proc Natl Acad Sci USA 1974; 74: 5463-5467.
25. Oksanen L, Öhman M, Heiman M, Kainulainen K, Kaprio J, Mustajoki P, Koivisto V, Koskenvuo M, Jänne OA, Peltonen L, Kontula K. Ob gene markers and serum leptin levels in human morbid obesity. Hum Genet 1997; 99: 559-564.
26. Banauch D, Brümmer W, Ebeling W, Metz H, Rindfrey H, Lang H. Eine glucose-dehydrogenase für die glucose-bestimmung in körperflüssigkeiten. Z Klin Chem Klin Biochem 1975; 13: 101-107.
27. Desbuquois B, Aurbach GD. Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J Clin Endocr 1971; 33: 732-738.
28. Bergmeyer HU. Metoden der enzymatischen analyse, 3. Auflage, Bd. II, Verlag Chemie: Weinheim 1974, p. 1878.
29. Siedel J, Hägele EO, Ziegenhorn J, Wahlefeld AW. Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin Chem 1983; 29: 1075-1080.
30. 2/dextran sulphate in its enzyme measurement. Clin Chem 1978; 24: 931-933.
31. Cochran WG. Some methods for strengthening the common chi-square tests. Biometrics 1954; 10: 417-451.
32. Havel PJ, Kasim-Karakas S, Dubuc GR, Mueller W, Phinney SD. Gender differences in plasma leptin concentrations. Nature Med 1996; 2: 949-950.
33. Caro JF. Clinical Review 26: Insulin resistance in obese and nonobese man. J Clin Endocrinol Metab 1991; 73: 691-695.
34. Kieffer TJ, Heller RS, Haberner JF, Leptin receptors expressed on pancreatic β-cells. Biochem Biophys Res Commun 1996; 224: 522-527.
35. Kieffer TJ, Heller SR, Leech CA, Holz GG, Habener JF. Leptin suppression of insulin secretion by activation of ATP-sensitive K channels in pancreatic beta-cells. Diabetes 1997; 46: 1087-1093.
36. Emilsson V, Liu YL, Cawthorne MA, Morton NM, Davenport M. Expression of the leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 1997; 46: 313-316.
37. Thompson DB, Janssen RC, Ossowski VM, Prochazka M, Knowler WC, Bogardus C. Evidence for linkage between a region on chromosome lp and the acute insulin response in Pima Indians. Diabetes 1995; 44: 478-481.
38. Ross J. mRNA stability in mammalian cells. Micmbiol Rev 1995; 59: 423-450.
39. Brown CY, Lagnado CA, Goodall GJ. A cytokine mRNA-destabilizing element that is structurally and functionally distinct from A + U-rich elements. Proc Natl Acad Sci USA 1996; 93: 13721-13725.