Mice deficient for the type II topoisomerase-like DNA transesterase Spo11 show normal immunoglobulin somatic hypermutation and class switching

European Journal of Immunology

Volumn 32, Issue 2, 2002, Pages 316-321

  Klein, Ulf ^a   Esposito, Gloria ^b   Baudat, Frédéric ^c   Keeney, Scott ^c,d   Jasin, Maria ^c,d  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF COLOGNE   (Germany)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

DNA double strand breaks; Ig class switching; Somatic hypermutation; Spo11 transesterase

Indexed keywords

ANTIBODY; ARCHAEAL PROTEIN; DINITROPHENYLHAPTEN; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN M; SPO11 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY AFFINITY; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DNA RECOMBINATION; DNA STRAND BREAKAGE; ENZYME DEFICIENCY; GENE REARRANGEMENT; IMMUNITY; IMMUNOGLOBULIN GENE; MEIOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SOMATIC MUTATION; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA, COMPLEMENTARY; ESTERASES; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN ISOTYPES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RNA, MESSENGER; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 0036178823     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200202)32:2<316::AID-IMMU316>3.0.CO;2-P     Document Type: Article

References (32)

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7. Antibody class switching
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11. Meiotic recombination hotspots
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13. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
14. The targeting of somatic hypermutation closely resembles that of meiotic mutation
15. Meiosis specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family
16. Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11
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