Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11

Molecular Cell

Volumn 6, Issue 5, 2000, Pages 989-998

  Baudat, Frédéric ^a   Manova, Katia ^a   Yuen, Julie Pui ^a   Jasin, Maria ^a   Keeney, Scott ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME BREAKAGE; CHROMOSOME DISORDER; GENETIC RECOMBINATION; GONAD DYSFUNCTION; MEIOSIS; MOUSE; NONHUMAN; OOCYTE; OOCYTE DEVELOPMENT; SEX DIFFERENTIATION; SEX DIFFERENTIATION DISORDER; SPERMATOCYTE; SPERMATOGENESIS; SYNAPTOGENESIS;

EID: 0033638183     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)00098-8     Document Type: Article

References (63)

1. RecA-like proteins are components of early meiotic nodules in lily
2. Dynamic changes in Rad51 distribution on chromatin during meiosis in male and female vertebrates
3. Distribution of the Rad51 recombinase in human and mouse spermatocytes
4. Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles
5. Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I
6. An atypical topoisomerase II from Archaea with implications for meiotic recombination
7. RecA homologs Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis
8. DMC1: A meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression
9. Fertility in mice requires X-Y pairing and a Y-chromosomal 'spermiogenesis' gene mapping to the long arm
10. Multiple roles of spo11 in meiotic chromosome behavior
11. Meiotic DNA breaks associated with recombination in S. pombe
12. Stem cells in the testis
13. Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis
14. Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis
15. Synaptonemal complex proteins: Occurrence, epitope mapping and chromosome disjunction
16. Mammalian MutS homologue 5 is required for chromosome pairing in meiosis
17. Mouse models of ovarian failure
18. An mre11 mutant of Coprinus cinereus has defects in meiotic chromosome pairing, condensation and synapsis
19. Genetic control of chromosome synapsis in yeast meiosis
20. Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family
21. A mouse homolog of the Saccharomyces cerevisiae meiotic recombination DNA transesterase Spo11p
22. The role of the SPO11 gene in meiotic recombination in yeast
23. MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice
24. p53, the cellular gatekeeper for growth and division
25. Transient, meiosis-induced expression of the rec6 and rec12 genes of Schizosaccharomyces pombe
26. Meiotic chromosome synapsis in a haploid yeast
27. Homologous pairing is reduced but not abolished in asynaptic mutants of yeast
28. A meiotic recombination checkpoint controlled by mitotic checkpoint genes
29. Gonadal expression of c-kit encoded at the W locus of the mouse
30. Apoptosis in mouse embryos: Elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice
31. The association of nonhomologous parts of chromosomes in the mid-prophase of meiosis in Zea mays
32. mei-W68 in Drosophila melanogaster encodes a Spo11 homolog: Evidence that the mechanism for initiating meiotic recombination is conserved
33. Meiotic synapsis in the absence of recombination
34. Identification and characterization of an SPO11 homolog in the mouse
35. Sex-chromosome pairing and male fertility
36. Histones H1 and H4 of surface-spread meiotic chromosomes
37. Rad51 immunocytology in rat and mouse spermatocytes and oocytes
38. Expression and nuclear localization of BLM, a chromosome stability protein mutated in Bloom's syndrome, suggest a role in recombination during meiotic prophase
39. Composition and role of the synaptonemal complex
40. Structure and function of an archaeal topoisomerase VI subunit with homology to the meiotic recombination factor Spo11
41. The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis
42. Temporal comparison of recombination and synaptonemal complex formation during meiosis in S. cerevisiae
43. Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog
44. Presynaptic association of Rad51 protein with selected sites in meiotic chromatin
45. Meiotic chromosomes: It takes two to tango
46. DNA double-strand breaks induce histone H2AX phosphorylation on serine 139
47. Cloning, characterization, and localization of mouse and human SPO11
48. The mouse Spo11 gene is required for meiotic chromosome synapsis
49. Differential gene expression of mammalian SPO11/TOP6A homologs during meiosis
50. Recombination at work for meiosis
51. Meiosis in the foetal mouse ovary. I. An analysis at the light microscope level using surface-spreading
52. a mice: A quantitative analysis of spermatogenesis throughout puberty
53. ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis
54. RAD51 and DMC1 form mixed complexes associated with mouse meiotic chromosome cores and synaptonemal complexes
55. Localization of RecA-like recombination proteins on chromosomes of the lily at various meiotic stages
56. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
57. A cis-acting locus that promotes crossing over between X chromosomes in Caenorhabditis elegans
58. Mouse testes contain two size classes of actin mRNA that are differentially expressed during spermatogenesis
59. The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis
60. The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility
61. The genetics of meiosis in Caenorhabditis elegans
62. The leptotene-zygotene transition of meiosis
63. Meiotic chromosomes: Integrating structure and function