Effect of truncated forms of the steroidogenic acute regulatory protein on intramitochondrial cholesterol transfer

Endocrinology

Volumn 139, Issue 9, 1998, Pages 3903-3912

  Wang, Xingjia ^a   Liu, Zhiming ^a   Eimerl, Sarah ^b   Timberg, Rina ^b   Weiss, Aryeh M ^b   Orly, Joseph ^b,c   Stocco, Douglas M ^a  

^a TEXAS TECH UNIVERSITY   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c ISRAEL ACADEMY OF SCIENCES AND HUMANITIES   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

FERREDOXIN; PREGNENOLONE; REGULATOR PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LYSATE; CELL STRAIN COS1; CHOLESTEROL TRANSPORT; CYTOSOL; IMMUNOBLOTTING; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STEROIDOGENESIS;

EID: 0031730449     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.9.6204     Document Type: Article

References (47)

1. Simpson ER, Boyd GS 1966 The cholesterol side-chain cleavage system of the adrenal cortex: a mixed function oxidase. Biochem Biophys Res Commun 24:10-17
2. Simpson ER, Boyd GS 1967 The cholesterol side-chain cleavage system of the adrenal cortex. Eur J Biochem 2:275-285
3. Ferguson JJ 1962 Puromycin and adrenal responsiveness to adrenocorticotropic hormone. Biochim Biophys Acta 57:616-617
4. Ferguson JJ 1963 Protein synthesis and adrenocorticotropin responsiveness. J Biol Chem 238:2754-2759
5. Garren LD, Ney RL, Davis WW 1965 Studies on the role of protein synthesis in the regulation of corticosterone production by ACTH in vivo. Proc Natl Acad Sci USA 53:1443-1450
6. Stocco DM, Clark BJ 1996 The role of the steroidogenic acute regulatory (StAR) protein in steroidogenesis. Biochem Pharmacol 51:197-205
7. Stocco DM, Clark BJ 1996 Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev 17:221-244
8. Stocco DM 1996 Acute regulation of steroidogenesis in the Leydig cell. In: Payne A, Hardy M, Russell L (eds) The Leydig Cell. Cache River Press, Clearwater, pp 241-257
9. Stocco DM, Clark BJ 1997 The role of the steroidogenic acute regulatory protein in steroidogenesis. Steroids 62:29-36
10. Clark BJ, Wells J, King SR, Stocco DM 1994 The purification, cloning, and expression of a novel LH-induced mitochondrial protein in MA-10 mouse Leydig tumor cells: characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem 269:28314-28322
11. + in H295R adrenocortical cells. Mol Cell Endocrinol 15:215-219
12. Juengel JL, Meberg BM, Turzillo AM, Nett TM, Niswender GD 1995 Hormonal regulation of messenger ribonucleic acid encoding steroidogenic acute regulatory protein in ovine corpora lutea. Endocrinology 136:5423-5429
13. Hartung S, Rust W, Balvers M, Ivell R 1995 Molecular cloning and in vivo expression of the bovine steroidogenic acute regulatory protein. Biochem Biophys Res Commun 215:646-653
14. Cherradi N, Rossier MF, Vallotton MB, Capponi AM 1946 Calcium stimulates intramitochondrial cholesterol transfer in bovine adrenal glomerulosa cells. J Biol Chem 271:25971-25975
15. Cherradi N, Rossier MF, Vallotton MB, Timberg R, Friedberg I, Orly J, Wang XJ, Stocco DM, Capponi AM 1997 Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein, P450 side-chain cleavage and 3β-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells. J Biol Chem 272:7899-7907
16. Lin D, Sugawara T, Strauss III JF, Clark BJ, Stocco DM, Saenger P, Rogol A, Miller WL 1995 Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 267:1828-1831
17. Arakane F, Sugawara T, Nishino H, Liu Z, Holt JA, Pain D, Stocco DM, Miller WL, Strauss JF 1996 Steroidogenic acute regulatory protein (StAR) retains activity in the absence of its mitochondrial import sequence: implications for the mechanism of StAR action. Proc Natl Acad Sci USA 93:13731-13736
18. Ascoli M 1981 Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses. Endocrinology 108:88-95
19. King SR, Ronen-Fuhrmann T, Timberg R, Clark BJ, Orly J, Stocco DM 1945 Steroid production after in vitro transcription, translation, and mitochondrial processing of protein products of complementary deoxyribonucleic acid for steroidogenic acute regulatory protein. Endocrinology 136:5165-5176
20. Harikrishna JA, Black SM, Szklarz GD, Miller WL 1993 Construction and function of fusion enzymes of the human cytochrome P450scc System. DNA Cell Biol 12:371-379
21. Stocco DM, Kilgore MW 1988 Induction of mitochondrial proteins in MA-10 Leydig tumour cells with human choriogonadotropin. Biochem J 249:95-103
22. Cherradi N, Defaye G, Chambaz EM 1994 Characterization of the 3β-hydroxysteroid dehydrogenase activity associated with bovine adrenocortical mitochondria. Endocrinology 134:1358-1364
23. Bandlow W 1972 Membrane separation and biogenesis of the outer membrane of yeast mitochondria. Biochim Biophys Acta 282:105-122
24. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72:248-254
25. Orly J, Clemens JW, Singer O, Richards JS 1996 Effects of hormones and protein kinase inhibitor on expression of steroidogenic enzyme promotes in electroporated primary rat granulosa cells. Biol Reprod 54:208-218
26. Ronen-Fuhrmann T, Timberg R, King SR, Hales KH., Hales DB, Stocco DM, Orly J 1998 Spatio-temporal expression patterns of steroidogenic acute regulatory protein (StAR) during follicular development in the rat ovary. Endocrinology 139:303-315
27. Farkash Y, Timberg R, Orly J 1986 Preparation of antiserum to rat cytochrome P-450 side chain cleavage and its use for ultrastructural localization of the immuno-reactive enzyme by protein A-gold technique. Endocrinology 118:1353-1365
28. Schulze-Osthoff K, Bakker AC, Vanhaesebroeck B, Beyaert R, Jacob WA, Fiers W 1992 Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions: evidence for the involvement of mitochondrial radical generation. J Biol Chem 267:5317-5323
29. Phillips MC, Johnson WJ, Rothblat GH 1987 Mechanisms and consequences of cellular cholesterol exchange and transfer. Biochim Biophys Acta 906:223-276
30. Reinhart MP 1990 Intracellular sterol trafficking. Experientia 46:599-611
31. Simpson ER, Jefcoate CR, Brownie AC, Boyd GS 1972 The effect of ether anaesthesia stress on cholesterol-side-chain cleavage and cytochrome P450 in rat-adrenal mitochondria. Eur J Biochem 28:442-450
32. Brownie AC, Simpson ER, Jefcoate CR, Boyd GS, Orme-Johnson WH, Beinert H 1972 Effect of ACTH on cholesterol side-chain cleavage in rat adrenal mitochondria. Biochem Biophys Res Commun 46:483-490
33. Farese RV, Prudente WJ 1977 On the requirement for protein synthesis during corticotropin-induced stimulation of cholesterol side chain cleavage in rat adrenal mitochondrial and solubilized desmolase preparations. Biochim Biophys Acta 496:567-570
34. Tee M, Lin D, Sugaware T, Holt JA, Guiguen Y, Buckingham B, Strauss III JF, Miller WL 1995 T-A transversion 11 bp from a splice acceptor site in the human gene for steroidogenic acute regulatory protein causes congenital lipoid adrenal hyperplasia. Hum Mol Genet 4:2299-2305
35. Bose HS, Sugawara T, Strauss JF, Miller WL 1996 The pathophysiology and genetics of congenital lipoid adrenal hyperplasia. N Engl J Med 335:1870-1878
36. Wang XJ, King SR, Liu ZM, Stocco DM 1996 Specific binding of the steroidogenic acute regulatory protein to a mitochondrial membrane protein complex. Biol Reprod [Suppl] 54:113
37. Schwaiger M, Herzog V, Neupert W 1987 Characterization of translocation contact sites involved in the import of mitochondrial proteins. J Cell Biol 105:235-246
38. Pon L, Moll T, Vestweber D, Marshallsay B, Schatz G 1989 Protein import into mitochondria: ATP-dependent protein translocation activity in a submitochondrial fraction enriched in membrane contact sites and specific proteins. J Cell Biol 109:2603-2616
39. Pfanner N, Rassow J, Wienhues U, Hergersberg C, Sollner, Becker K, Neupert W 1990 Contact sites between inner and outer membranes: structure and role in protein translocation into the mitochondria. Biochim Biophys Acta 1018:239-242
40. Jefcoate CR, McNamara BC, Artemenko I, Yamazaki T 1992 Regulation of cholesterol movement to mitochondrial cytochrome P450scc in steroid hormone synthesis. J Steroid Biochem Mol Biol 43:751-767
41. Cherradi N, Chambaz EM, Defaye G 1995 Organization of 3β-hydroxysteroid dehydrogenase/isomerase and cytochrome P-450scc into a catalytically active molecular complex in bovine adrenocortical mitochondria. J Steroid Biochem Mol Biol 55:507-514
42. Papadopoulos V, Mukhin AG, Costa E, Krueger KE 1990 The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. J Biol Chem 265:3772-3779
43. Papadopoulos V 1993 Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocr Rev 14:222-240
44. Boujrad N, Hudson JR, Papadopoulos V 1993 Inhibition of hormone-stimulated steroidogenesis in cultured Leydig tumor cells by a cholesterol-linked phosphorothioate oligodeoxynucleotide antisense to diazepam-binding inhibitor. Proc Natl Acad Sci USA 90:5728-5731
45. Garnier M, Boujrad N, Ogwuegbu SO, Hudson JR, Papadopoulos V 1994 The polypeptide diazepam-binding inhibitor and a higher affinity mitochondrial peripheral-type benzodiazepine receptor sustain constitutive steroidogenesis in the R2C tumor cell line. J Biol Chem 269:22105-22112
46. Lieberman S, Prassad VVK 1990 Heterodox notions on pathways of steroidogenesis. Endocr Rev 11:469-493
47. Prassad VVK, Mathur C, Welch M, Lieberman S 1992 Steroidogenic potential of lyophilized mitochondria from bovine adrenocortical tissue. Proc Natl Acad Sci USA 89:4173-4177