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Volumn 27, Issue 12, 1997, Pages 3398-3403

Critical test of hot spot motifs for immunoglobulin hypermutation

Author keywords

Palindrome; Revertant; Stop codon

Indexed keywords

IMMUNOGLOBULIN; PALINDROMIC DNA;

EID: 0031460776     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.1830271239     Document Type: Article
Times cited : (19)

References (35)
  • 1
    • 0031041155 scopus 로고    scopus 로고
    • The promotion of V region hypermutation
    • Scharff, M. D., Poltoratsky, V. and Green, N. S., The promotion of V region hypermutation. J. Exp. Med. 1997. 187: 185-188.
    • (1997) J. Exp. Med. , vol.187 , pp. 185-188
    • Scharff, M.D.1    Poltoratsky, V.2    Green, N.S.3
  • 4
  • 5
    • 0029927054 scopus 로고    scopus 로고
    • The mechanism of somatic hypermutation studied with transgenic and transfected target genes
    • Storb, U., Peters, A., Klotz, E., Rogerson, B. and Hackett, J. Jr, The mechanism of somatic hypermutation studied with transgenic and transfected target genes. Semin. Immunol. 1996. 8: 131-140.
    • (1996) Semin. Immunol. , vol.8 , pp. 131-140
    • Storb, U.1    Peters, A.2    Klotz, E.3    Rogerson, B.4    Hackett Jr., J.5
  • 6
    • 0029996999 scopus 로고    scopus 로고
    • Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches
    • Tumas-Brundage, K., Vora, K. A., Giusti, A. M. and Manser, T., Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches. Semin. Immunol. 1996. 8: 141-150.
    • (1996) Semin. Immunol. , vol.8 , pp. 141-150
    • Tumas-Brundage, K.1    Vora, K.A.2    Giusti, A.M.3    Manser, T.4
  • 7
    • 0029883777 scopus 로고    scopus 로고
    • Affinity maturation and class switching
    • Wabl, M. and Steinberg, C., Affinity maturation and class switching. Curr. Opin. Immunol. 1996. 8: 89-92.
    • (1996) Curr. Opin. Immunol. , vol.8 , pp. 89-92
    • Wabl, M.1    Steinberg, C.2
  • 9
    • 0022386943 scopus 로고
    • Molecular events during maturation of the immune response to oxazolone
    • Berek, C., Griffiths, G. M. and Milstein, C., Molecular events during maturation of the immune response to oxazolone. Nature 1985. 316: 412-418.
    • (1985) Nature , vol.316 , pp. 412-418
    • Berek, C.1    Griffiths, G.M.2    Milstein, C.3
  • 10
    • 0023722177 scopus 로고
    • Mutational hot spots in Ig V region genes of human follicular lymphomas
    • Levy, S., Mendel, E., Kon, S., Avnur, Z. and Levy, R., Mutational hot spots in Ig V region genes of human follicular lymphomas. J. Exp. Med. 1988. 168: 475-489.
    • (1988) J. Exp. Med. , vol.168 , pp. 475-489
    • Levy, S.1    Mendel, E.2    Kon, S.3    Avnur, Z.4    Levy, R.5
  • 11
    • 0027499308 scopus 로고
    • Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots
    • Betz, A. G., Rada, C., Pannell, R., Milstein, C. and Neuberger, M. S., Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc. Natl. Acad. Sci. USA 1993. 90: 2385-2388.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2385-2388
    • Betz, A.G.1    Rada, C.2    Pannell, R.3    Milstein, C.4    Neuberger, M.S.5
  • 13
    • 0028577994 scopus 로고
    • Somatic mutation of immunoglobulin lambda chains: A segment of the major intron hypermutates as much as the complementarity-determining regions
    • Gonzalez-Fernandez, A., Gupta, S. K., Pannell, R., Neuberger, M. S. and Milstein, C., Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions. Proc. Natl. Acad. Sci. USA 1994. 91: 12614-12618.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12614-12618
    • Gonzalez-Fernandez, A.1    Gupta, S.K.2    Pannell, R.3    Neuberger, M.S.4    Milstein, C.5
  • 14
    • 0031569118 scopus 로고    scopus 로고
    • Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes
    • Dorner, T., Brezinschek, H. P., Brezinschek, R. I., Foster, S. J., Domiati-Saad, R. and Lipsky, P. E., Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes. J. Immunol. 1997. 158: 2779-2789.
    • (1997) J. Immunol. , vol.158 , pp. 2779-2789
    • Dorner, T.1    Brezinschek, H.P.2    Brezinschek, R.I.3    Foster, S.J.4    Domiati-Saad, R.5    Lipsky, P.E.6
  • 15
    • 0029947265 scopus 로고    scopus 로고
    • Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells
    • Smith, D. S., Creadon, G., Jena, P. K., Portanova, J. P., Kotzin, B. L. and Wysocki, L. J., Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells. J. Immunol. 1996. 156: 2642-2652.
    • (1996) J. Immunol. , vol.156 , pp. 2642-2652
    • Smith, D.S.1    Creadon, G.2    Jena, P.K.3    Portanova, J.P.4    Kotzin, B.L.5    Wysocki, L.J.6
  • 16
    • 0027227311 scopus 로고
    • Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes
    • Betz, A. G., Neuberger, M. S. and Milstein, C., Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol. Today 1993. 14: 405-411.
    • (1993) Immunol. Today , vol.14 , pp. 405-411
    • Betz, A.G.1    Neuberger, M.S.2    Milstein, C.3
  • 18
    • 0026443954 scopus 로고
    • Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
    • Rogozin, I. B. and Kolchanov, N. A., Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim. Biophys. Acta 1992. 1171: 11-18.
    • (1992) Biochim. Biophys. Acta , vol.1171 , pp. 11-18
    • Rogozin, I.B.1    Kolchanov, N.A.2
  • 19
    • 0030450401 scopus 로고    scopus 로고
    • Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation
    • Goyenechea, B. and Milstein, C., Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation. Proc. Natl. Acad. Sci. USA 1996. 93: 13979-13984.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13979-13984
    • Goyenechea, B.1    Milstein, C.2
  • 20
    • 0028968928 scopus 로고
    • A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene
    • Zhu, M., Rabinowitz, J. L., Green, N. S., Kobrin, B. J. and Scharff, M. D., A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene. Proc. Natl. Acad. Sci. USA 1995. 92: 2810-2814.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 2810-2814
    • Zhu, M.1    Rabinowitz, J.L.2    Green, N.S.3    Kobrin, B.J.4    Scharff, M.D.5
  • 21
    • 0029047213 scopus 로고
    • Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line
    • Green, N. S., Rabinowitz, J. L., Zhu, M., Kobrin, B. J. and Scharff, M. D., Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line. Proc. Natl. Acad. Sci. USA 1995. 92: 6304-6308.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 6304-6308
    • Green, N.S.1    Rabinowitz, J.L.2    Zhu, M.3    Kobrin, B.J.4    Scharff, M.D.5
  • 22
    • 0030071749 scopus 로고    scopus 로고
    • An immunoglobulin mutator that targets G.C base pairs
    • Bachl, J. and Wabl, M., An immunoglobulin mutator that targets G.C base pairs. Proc. Natl. Acad. Sci. USA 1996. 93: 851-855.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 851-855
    • Bachl, J.1    Wabl, M.2
  • 23
    • 0029965649 scopus 로고    scopus 로고
    • Enhancers of hypermutation
    • Bachl, J. and Wabl, M., Enhancers of hypermutation. Immunogenetics 1996. 45: 59-64.
    • (1996) Immunogenetics , vol.45 , pp. 59-64
    • Bachl, J.1    Wabl, M.2
  • 24
    • 0345975560 scopus 로고
    • Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line
    • Wabl, M., Burrows, P. D., von Gabain, A. and Steinberg, C., Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line. Proc. Natl. Acad. Sci. USA 1985. 82: 479-482.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 479-482
    • Wabl, M.1    Burrows, P.D.2    Von Gabain, A.3    Steinberg, C.4
  • 25
    • 0022498511 scopus 로고
    • High rate of somatic point mutation in vitro in and near the variable-region segment of an immunoglobulin heavy chain gene
    • Meyer, J., Jäck, H.-M., Ellis, N. and Wabl, M., High rate of somatic point mutation in vitro in and near the variable-region segment of an immunoglobulin heavy chain gene. Proc. Natl. Acad. Sci. USA 1986. 83: 6950-6953.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 6950-6953
    • Meyer, J.1    Jäck, H.-M.2    Ellis, N.3    Wabl, M.4
  • 26
    • 0029557884 scopus 로고
    • A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro
    • Wu, H., Pelkonen, E., Knuutila, S. and Kaartinen, M., A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro. Eur. J. Immunol. 1995. 25: 3263-3269.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 3263-3269
    • Wu, H.1    Pelkonen, E.2    Knuutila, S.3    Kaartinen, M.4
  • 27
    • 0023972405 scopus 로고
    • Looping out and deletion mechanism for the immunoglobulin heavy-chain class switch
    • Jäck, H.-M., McDowell, M., Steinberg, C. M. and Wabl, M., Looping out and deletion mechanism for the immunoglobulin heavy-chain class switch. Proc. Natl. Acad. Sci. USA 1988. 85: 1581-1585.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 1581-1585
    • Jäck, H.-M.1    McDowell, M.2    Steinberg, C.M.3    Wabl, M.4
  • 28
    • 0020471790 scopus 로고
    • Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines
    • Alt, F. W., Rosenberg, N., Enea, V., Siden, E. and Baltimore, D., Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Mol. Cell Biol. 1982. 2: 386-400.
    • (1982) Mol. Cell Biol. , vol.2 , pp. 386-400
    • Alt, F.W.1    Rosenberg, N.2    Enea, V.3    Siden, E.4    Baltimore, D.5
  • 29
    • 0023378035 scopus 로고
    • High rates of deletions in the constant region segment of the immunoglobulin mu gene
    • Jäck, H.-M. and Wabl, M., High rates of deletions in the constant region segment of the immunoglobulin mu gene. Proc. Natl. Acad. Sci. USA 1987. 84: 4934-4938.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 4934-4938
    • Jäck, H.-M.1    Wabl, M.2
  • 31
    • 0019422455 scopus 로고
    • Expression of mu and gamma immunoglobulin heavy chains in different cells of a cloned mouse lymphoid line
    • Burrows, P. D., Beck, G. B. and Wabl, M. R., Expression of mu and gamma immunoglobulin heavy chains in different cells of a cloned mouse lymphoid line. Proc. Natl. Acad. Sci. USA 1981. 78: 564-568.
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 564-568
    • Burrows, P.D.1    Beck, G.B.2    Wabl, M.R.3
  • 32
    • 0021055938 scopus 로고
    • Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement
    • Burrows, P. D., Beck-Engeser, G. B. and Wabl, M. R., Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement. Nature 1983. 306: 243-246.
    • (1983) Nature , vol.306 , pp. 243-246
    • Burrows, P.D.1    Beck-Engeser, G.B.2    Wabl, M.R.3
  • 33
    • 0021930187 scopus 로고
    • Critical test of a sister chromatid exchange model for the immunoglobulin heavy-chain class switch
    • Wabl, M., Meyer, J., Beck-Engeser, G., Tenkhoff, M. and Burrows, P. D., Critical test of a sister chromatid exchange model for the immunoglobulin heavy-chain class switch. Nature 1985. 313: 687-689.
    • (1985) Nature , vol.313 , pp. 687-689
    • Wabl, M.1    Meyer, J.2    Beck-Engeser, G.3    Tenkhoff, M.4    Burrows, P.D.5
  • 34
    • 0026470596 scopus 로고
    • What limits affinity maturation of antibodies in Xenopus - The rate of somatic mutation or the ability to select mutants?
    • Wilson, M., Hsu, E., Marcuz, A., Courtet, M., Du Pasquier, L. and Steinberg, C., What limits affinity maturation of antibodies in Xenopus - the rate of somatic mutation or the ability to select mutants? EMBO J. 1992. 11: 4337-4347.
    • (1992) EMBO J. , vol.11 , pp. 4337-4347
    • Wilson, M.1    Hsu, E.2    Marcuz, A.3    Courtet, M.4    Du Pasquier, L.5    Steinberg, C.6
  • 35
    • 0028811073 scopus 로고
    • Somatic mutations during an immune response in Xenopus tadpoles
    • Wilson, M., Marcuz, A. and Du Pasquier, L., Somatic mutations during an immune response in Xenopus tadpoles. Dev. Immunol. 1995. 4: 227-234.
    • (1995) Dev. Immunol. , vol.4 , pp. 227-234
    • Wilson, M.1    Marcuz, A.2    Du Pasquier, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.