Neuropeptide Y counteracts the anorectic and weight reducing effects of ciliary neurotropic factor

Journal of Neuroendocrinology

Volumn 12, Issue 9, 2000, Pages 827-832

  Pu, S ^a,c   Dhillon, H ^a   Moldawer, L L ^a   Kalra, P S ^a   Kalra, S P ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Anorexia; Body weight; Ciliary neurotrophic factor; Neuropeptide Y

Indexed keywords

ANOREXIGENIC AGENT; APPETITE STIMULANT; CILIARY NEUROTROPHIC FACTOR; CYTOKINE; INTERLEUKIN 6; LEPTIN; NEUROPEPTIDE Y; OREXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FOOD INTAKE; GENE EXPRESSION; HYPOPHAGIA; HYPOTHALAMUS; HYPOTHESIS; INFECTION; INFLAMMATION; INFUSION; INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; WEIGHT GAIN; WEIGHT REDUCTION;

ANIMALS; ANOREXIA; BRAIN; CILIARY NEUROTROPHIC FACTOR; EATING; GENE EXPRESSION; HYPOTHALAMUS; LEPTIN; MALE; NEUROPEPTIDE Y; NEUROPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; WEIGHT LOSS;

EID: 0033840684     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2000.00526.x     Document Type: Article

References (48)

1. Cytokines and anorexia: A brief overview
2. Ciliary neurotrophic factor and its receptor complex
3. Ciliary neurotrophic factor: A review
4. Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response
5. Systemic administration of ciliary neurotrophic factor induces cachexia in rodents
6. Cachectin: Its impact on metabolism and nutritional status
7. Cachectic effect of ciliary neurotrophic factor on innervated skeletal muscle
8. Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y. comparison with leptin
9. Increased appetite augments hypothalamic NPY Y1 receptor gene expression: Effects of anorexigenic ciliary neurotropic factor
10. Positional cloning of the mouse obese gene and its human homologue
11. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
12. The anorexia and cachexia of inflammation can be explained by CNS production of ciliary neurotrophic factor
13. The role for IL-6, LIF and CNTF in the anorexia, acute phase protein and muscle proteolysis responses to inflammation
14. Immunohistochemical localization of ciliary neurotrophic factor receptor alpha expression in the rat nervous system
15. Intcracting appetite-regulating pathways in the hypothalamic regulation of body weight
16. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats
17. Is neuropeptide Y a naturally occuring appetite transducer?
18. Evidence that neuropeptide Y is a physiological signal for normal food intake
19. Potent neuropeptide Y YI receptor antagonist, 1229U91: Blockade of neuropeptide Y-induced and physiological food intake
20. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus
21. Increased hypothalamic neuropeptide Y expression following food deprivation
22. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food
23. Increased receptor sensitivity to neuropeptide Y in the hypothalamus may underlie transient hyperphagia and body weight gain
24. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
25. Evidence that dark-phase hyperphagia induced by neurotoxin 6-hydroxydopamine may be due to decreased leptin and increased neuropeptide Y signaling
26. Disruption in neuropeptide Y and leptin signaling in obese ventromedial hypothalamic-lesioned rats
27. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
28. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
29. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: A novel circuit implicated in metabolic and endocrine regulations
30. The lateral hypothalamic area revisited: Ingestive behavior
31. Neurons containing hypocretin (orexin) project to multiple neuronal systems
32. Widespread distribution of orexin in rat brain and its regulation upon fasting
33. Food-intake elicited by central administration of orexin/hypocretins: Identification of hypothalamic site of action
34. Hypocretin/orexin-and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptides Y and agouti gene-related protein systems
35. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats
36. Role of neuropeptide-Y in episode luteinizing hormone release in ovariectomized rats: An excitatory component and opioid involvement
37. Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats
38. Daily changes in hypothalamic gene expression of neuropeptide Y, galanin, proopiomelanocortin, and adipocyte leptin gene expression and secretion: Effects of food restriction
39. Multiple cytokines and acute inflammation raise mouse leptin levels: Potential role in inflammatory anorexia
40. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters
41. Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance
42. Long-term correction of obesity using centrally delivered rAAV encoding anorexigenic cytokines
43. The role of neuropeptide Y in the antiobesity action of the obese gene product
44. Neurotransmitters, neuropeptides and binding sites in the rat mediobasal hypothalamus: Effects of monosodium glutamate (MSG) lesions
45. Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in proopiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus
46. Regulation of neurotransmission in the arcuate nucleus of the rat by different neuropeptide Y receptors
47. Expression of ciliary neurotrophic factor receptor mRNA and protein in the early postnatal and adult rat nervous system
48. Inhibition of Neuropeptide Y (NPY) induced feeding and c-FOS response in magnocellular paraventricular nucleus by a NPY receptor antogonist: Asile of NPY action