Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region

Genome Research

Volumn 11, Issue 12, 2001, Pages 2085-2094

  Paulsen, Martina ^a,d   Takada, Shuji ^a   Youngson, Neil A ^a   Benchaib, Mehdi ^b   Charlier, Carole ^c   Segers, Karin ^c   Georges, Michel ^c   Ferguson Smith, Anne C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Hôpital Edouard Herriot Pavillon K   (France)

^c UNIVERSITY OF LIÈGE   (Belgium)

^d SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; REGULATOR PROTEIN;

ARTICLE; BINDING SITE; CHROMOSOME 12; COMPARATIVE STUDY; CONTROLLED STUDY; CPG ISLAND; DNA CLEAVAGE; DNA FLANKING REGION; GENE CONTROL; GENE LOCUS; GENE MAPPING; GENE SEQUENCE; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; GENOME IMPRINTING; HUMAN; MAMMAL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRENATAL GROWTH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN METHYLATION; SEQUENCE ANALYSIS; SHEEP; SPECIES DIFFERENCE; STRUCTURE ANALYSIS; TANDEM REPEAT;

ANIMALS; BINDING SITES; CONSERVED SEQUENCE; CPG ISLANDS; DNA-BINDING PROTEINS; GENETIC MARKERS; GENOMIC IMPRINTING; HUMANS; INTERSPERSED REPETITIVE SEQUENCES; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PROTEINS; REPRESSOR PROTEINS; SHEEP; TRANSCRIPTION FACTORS;

MAMMALIA; OVIS ARIES;

EID: 0035211656     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.206901     Document Type: Article

References (42)

1. A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene
2. Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: The Lyon repeat hypothesis
3. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
4. Breakpoint mapping positions of the callipyge gene within a 450 kilobase chromosome segment containing the Gtl2 gene
5. The human MAGEL2 gene and its mouse homologue are paternally expressed and mapped to the Prader-Willi region
6. Human-ovine comparative sequencing of a 250 kilobase imprinted domain encompassing the clpg gene and identification of six imprinted transcripts: DLK1, GTL2, DAT, PERL, antiPERL, and MEGC
7. Single step method of RNA isolation by acid Guanidinium Thiocyanate-Phenol-Chloroform extraction
8. Parental imprinting of the mouse insulin-like growth factor II gene
9. Active conservation of noncoding sequences revealed by three-way species comparisons
10. Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes
11. Sequence and functional comparison in the Beckwith-Wiedemann region: Implications for a novel imprinting centre and extended imprinting
12. Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes
13. Embryological and molecular investigations of parental imprinting on mouse chromosome 7
14. Parental-origin-specific epigenetic modification of the mouse H19 gene
15. Compositional bias in DNA
16. Parental origin effects in human trisomy for chromosome 14q: Implications for genomic imprinting
17. Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12
18. Roles for genomic imprinting and the zygotic genome in placental development
19. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
20. Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
21. An enhancer deletion affects both H19 and Igf2 expression
22. X-chromosome inactivation: A repeat hypothesis
23. Parallel adaptive radiations in two major clades of placental mammals
24. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q
25. Molecular phylogenetics and the origins of placental mammals
26. Characteristics of imprinted genes
27. Comparative genome analysis of the mouse imprinted gene Impact and its nonimprinted human homolog IMPACT: Toward the structural basis of species-specific imprinting
28. Sequence and comparative analysis of the mouse 1-Megabase region orthologous to the human 11p15 imprinted domain
29. Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse
30. Parental imprinting: Potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene
31. Long-range RNA interaction of two sequence elements required for endonucleolytic cleavage of human insulin-like growth factor II mRNAs
32. The Dlk1 and Gtl2 genes are linked and reciprocally imprinted
33. Gtl2lacZ an insertional mutation on mouse Chromosome 12 with parental origin-dependent phenotype
34. The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA
35. PipMaker-A web server for aligning two genomic DNA sequences
36. Interspersed repeats and other mementos of transposable elements in mammalian genomes
37. Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome
38. Search for imprinted regions on chromosome 14: Comparison of maternal and paternal UPD cases with cases of chromosome 14 deletion
39. Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function
40. Dlk (Delta-like) and Gtl2 are closely linked reciprocally imprinted genes on mouse chromosome 12 and are paternally methylated and co-expressed during development
41. Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in Igf2/H19 regulation