Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q

Genes to Cells

Volumn 5, Issue 3, 2000, Pages 211-220

  Miyoshi, Naoki ^a,b,c   Wagatsuma, Hirotaka ^a,c   Wakana, Shigeharu ^c,d   Shiroishi, Toshihiko ^e   Nomura, Masashi ^a   Aisaka, Kohzoh ^f   Kohda, Takashi ^a,c   Azim Surani, M ^g,h   Kaneko Ishino, Tomoko ^c,i   Ishino, Fumitoshi ^a,c  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b Fellow Cancer Res Japan Soc P   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^e NATIONAL INSTITUTE OF GENETICS   (Japan)

^f TEIKYO UNIVERSITY   (Japan)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^h UNIVERSITY OF CAMBRIDGE   (United Kingdom)

ⁱ TOKAI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RNA;

ANIMAL TISSUE; ARTICLE; CHROMOSOME 12; CHROMOSOME 14Q; CHROMOSOME DUPLICATION; CHROMOSOME MAP; CONTROLLED STUDY; DNA HYBRIDIZATION; EMBRYO; GENE EXPRESSION; GENE STRUCTURE; GENOME IMPRINTING; GROWTH; HUMAN; HUMAN TISSUE; MENTAL PERFORMANCE; MOLECULAR CLONING; MOUSE; MUSCULOSKELETAL SYSTEM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UNIPARENTAL DISOMY;

ANIMALS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 14; GENOME; GENOME, HUMAN; GENOMIC IMPRINTING; HUMANS; MICE;

ANIMALIA;

EID: 6744221197     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2000.00320.x     Document Type: Article

References (37)

1. Antonarakis, S.E., Blouin, J.L., Maher, J., Avramopoulos, D., Thomas, G. & Talbot, C.C. Jr (1993) Maternal uniparental disomy for human chromosome 14, due to loss of a chromosome 14 from somatic cells with t(13;14) trisomy 14. Am. J. Hum. Genet. 52, 1145-1152.
2. Beechey, C.V. & Cattanach, B.M. (1997). Mouse Genome 95, 161.
3. Berends, M.J., Hordijk, R., Scheffer, H., Oosterwijk, J.C., Halley, D.J. & Sorgedrager, N. (1999) Two cases of maternal uniparental disomy 14 with a phenotype overlapping with the Prader-Willi phenotype. Am. J. Med. Genet. 84, 76-79.
4. Buiting, K., Saitoh, S., Gross, S., et al. (1995) Inherited microdeletions in the Angelman and Prader-Willi syndromes define an imprinting centre on human chromosome 15. Nat. Genet. 9, 395-400.
5. Cotter, P.D., Kaffe, S., McCurdy, L.D., Jhaveri, M., Willner, J.P. & Hirschhorn, K. (1997) Paternal uniparental disomy for chromosome 14: a case report and review. Am. J. Med. Genet. 70, 74-79.
6. Coviello, D.A., Panucci, E., Mantero, M.M., et al. (1996) Maternal uniparental disomy for chromosome 14. Acta. Genet. Med. Gemelloll. (Roma) 45, 169-172.
7. Cox, D.W., Gedde-Dahl, T. Jr, Menon, A.G., et al. (1995) Report of the second international workshop on human chromosome 14 mapping 1994. Cytogenet. Cell Genet. 69, 159-174.
8. Engel, E. (1997) Uniparental disomy (UPD). Genomic imprinting and a case for new genetics (prenatal and clinical implications: the 'Likon' concept). Ann. Genet. 40, 24-34.
9. Fokstuen, S., Ginsburg, C., Zachmann, M. & Schinzel, A. (1999) Maternal uniparental disomy 14 as a cause of intrauterine growth retardation and early onset of puberty. J. Pediatr. 134, 689-695.
10. Glenn, C.C., Driscoll, D.J., Yang, T.P. & Nicholls, R.D. (1997) Genomic imprinting: potential function and mechanisms revealed by the Prader-Willi and Angelman syndromes. Mol. Hum. Reprod. 3, 321-332.
11. Healey S., Powell, F., Battersby M., Chenevix-Trench, G. & McGill, J. (1994) Distinct phenotype in maternal uniparental disomy of chromosome 14. Am. J. Med. Genet. 51, 147-149.
12. Kagitani, F., Kuroiwa, Y., Wakana, S., et al. (1997) Peg5/ Neuronatin is an imprinted gene located on sub-distal chromosome 2 in the mouse. Nucl. Acids Res. 17, 3428-3432.
13. Kaneko-Ishino, T., Kuroiwa, Y., Kohda, T., et al. (1997) Systematic approaches for the identification of imprinted genes. In: Frontiers in Molecular Biology: Genomic Imprinting (eds M.A. Surani & W. Reik), pp. 146-164. Oxford, UK: IRL Press.
14. Kaneko-Ishino, T., Kuroiwa, Y., Miyoshi, N., et al. (1995) Peg1/ Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridization. Nat. Genet. 11, 52-59.
15. Kuroiwa, Y., Kaneko-Ishino, T., Kagitani, F., et al. (1996) Peg3 imprinted gene on proximal chromosome 7 encodes for a zinc finger protein. Nat. Genet. 12, 186-190.
16. Ledbetter, D.H. & Engel, E. (1995) Uniparental disomy in humans: development of an imprinting map and its implications for prenatal diagnosis. Hum. Mol. Genet. 4, 1757-1764.
17. Martin, R.A., Sabol, D.W. & Rogan, P.K. (1999) Maternal uniparental disomy of chromosome 14 confined to an interstitial segment (14q23-14q24.2). J. Med. Genet. 36, 633-636.
18. McGrath, J. & Solter, D (1984) Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell 37, 179-183.
19. Miyoshi, N., Kuroiwa, Y., Kohda, T., et al. (1998a) Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome gene. Proc. Natl. Acad. Sci. USA 95, 1102-1107.
20. Miyoshi, O., Hayashi, S., Fujimoto, M., Tomita, H., Sohda, M. & Niikawa, N. (1998b) Maternal uniparental disomy for chromosome 14 in a boy with intrauterine growth retardation. J. Hum. Genet. 43, 138-142.
21. Papenhausen, P.R., Mueller, O.T., Johnson, V.P., Sutcliffe, M., Diamond, T.M. & Kousseff, B.G. (1995) Uniparental isodisomy of chromosome 14 in two cases: an abnormal child and a normal adult. Am. J. Med. Genet. 59, 271-275.
22. Pentao, L., Lewis, R.A., Ledbetter, D.H., Patel, P.I. & Lupski, J.R. (1992) Maternal uniparental isodisomy of chromosome 14: association with autosomal recessive rod monochromacy. Am. J. Hum. Genet. 50, 690-699.
23. Ralph, A., Scott, F., Tiernan, C., et al. (1999) Maternal uniparental isodisomy for chromosome 14 detected prenatally. Prenat. Diagn. 19, 681-684.
24. Reik, W., Brown, K.W., Schneid, H., Le Bouc, Y., Bickmore, W. & Maher, E.R. (1995) Imprinting mutations in the Beck-with-Wiedemann syndrome suggested by altered imprinting pattern in the IGF2-H19 domain. Hum. Mol. Genet. 4, 2379-2385.
25. Robinson, W.P. & Langlois, S. (1996) Phenotype of maternal UPD (14). Am. J. Med. Genet. 66, 89.
26. Schuster-Gossler, K., Bilinski, P., Sado, T., Ferguson-Smith, A. & Gossler, A. (1998) The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA. Dev. Dyn. 212, 214-228.
27. Schuster-Gossler, K., Simon-Chazottes, D., Guenet, J.L., Zachgo, J. & Gossler, A. (1996) Gtl2lacZ, an insertional mutation on mouse chromosome 12 with parental origin-dependent phenotype. Mamm. Genome 7, 20-24.
28. Sirchia, S.M., De Andreis, C., Pariani, S., et al. (1994) Chromosome 14 maternal uniparental disomy in the euploid cell line of a fetus with mosaic 46,XX/47,XX,+14 karyotype. Hum. Genet. 94, 355-358.
29. Splitt, M.P. & Goodship, J.A. (1997) Another case of maternal uniparental disomy chromosome 14 syndrome. Am. J. Med. Genet. 72, 239-240.
30. Surani, M.A., Barton, S.C. & Norris, M.L. (1984) Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis. Nature 308, 548-550.
31. Surani, M.A., Barton, S.C. & Norris, M.L. (1986) Nuclear transplantation in the mouse: heritable differences between parental genomes after activation of the embryonic genome. Cell 45, 127-136.
32. Temple, I.K., Cockwell, A., Hassold, T., Pettay, D. & Jacobs, P. (1991) Maternal uniparental disomy for chromosome 14. J. Med. Genet. 28, 511-514.
33. Tilghman, S.M. (1999) The sins of the fathers and mothers: genomic imprinting in mammalian development. Cell 96, 185-193.
34. Tomkins, D.J., Roux, A.F., Waye, J., Freeman V.C., Cox, D.W. & Whelan, D.T. (1996) Maternal uniparental isodisomy of human chromosome 14 associated with a paternal t(13q14q) and precocious puberty. Eur. J. Hum. Genet. 4, 153-159.
35. Walter, C.A., Shaffer, L.G., Kaye, C.I., Huff, et al. (1996) Short-limb dwarfism and hypertrophic cardiomyopathy in a patient with paternal isodisomy 14:45,XY,idic(14)(p11). Am. J. Med. Genet. 65, 259-265.
36. Wang, J.C., Passage, M.B., Yen, P.H., Shapiro, L.J. & Mohandas, T.K. (1991) Uniparental heterodisomy for chromosome 14 in a phenotypically abnormal familial balanced 13/14 Robertsonian translocation carrier. Am. J. Hum. Genet. 48, 1069-1074.
37. Wutz, A., Smrzka, O.W., Schweifer, N., Schellander, K., Wagner, E.F. & Barlow, D.P. (1997) Imprinted expression of the Igf2r gene depends on an intronic CpG island. Nature 389, 745-749.