An upstream repressor element plays a role in Igf2 imprinting

EMBO Journal

Volumn 20, Issue 13, 2001, Pages 3518-3525

  Eden, Sharon ^a   Constancia, Miguel ^b   Hashimshony, Tamar ^a   Dean, Wendy ^b   Goldstein, Beth ^a   Johnson, Alfred C ^c   Keshet, Ilana ^a   Reik, Wolf ^b   Cedar, Howard ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

GCF; Imprinting; Methylation

Indexed keywords

TRANS ACTING FACTOR;

ALLELE; ARTICLE; DNA METHYLATION; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REPRESSOR GENE;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELLS, CULTURED; CHIMERA; CROSSES, GENETIC; DNA METHYLATION; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; GENOMIC IMPRINTING; GENOMIC LIBRARY; INSULIN-LIKE GROWTH FACTOR II; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS; REPRESSOR PROTEINS; RESTRICTION MAPPING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 0035796466     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.13.3518     Document Type: Article

References (38)

1. Epigenetic mechanisms underlying the imprinting of the mouse H19 gene
2. Evidence for positive and negative regulation in the promoter of the chicken δ1-crystallin gene
3. The ontogeny of allele-specific methylation associated with imprinted genes in the mouse
4. A silencer element identified in Drosophila is required for imprinting of H19 reporter transgenes in mice
5. Imprinting mechanisms
6. Deletion of a silencer element in igf2 results in loss of imprinting independent of H19
7. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
8. Immunodepletion EMSA: A novel method to identify proteins in a protein-DNA complex
9. DNA methylation models histone acetylation
10. Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes
11. Chromatin structure and imprinting: Developmental control of DNase-I sensitivity in the mouse insulin-like growth factor 2 gene
12. Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans
13. A new technique for the assay of infectivity of human adenovirus 5 DNA
14. Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken β-globin chromosomal domain
15. Genomic deletion of an imprint maintenance element abolishes imprinting of both insulin-like growth factor II and H19
16. Expression and chromosomal localization of the gene for the human transcriptional repressor GCF
17. Igf2 imprinting does not require its own DNA methylation or H19 RNA
18. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
19. Molecular cloning and characterization of a human DNA binding factor that represses transcription
20. DNA methylation affects the formation of active chromatin
21. GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury
22. Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site specific recombinase
23. A small scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing
24. An enhancer deletion affects both H19 and Igf2 expression
25. Role for DNA methylation in genomic imprinting
26. The pIC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation
27. Visualizing an olfactory sensory map
28. Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2
29. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
30. Expression of a preproinsulin-β-galactosidase gene fusion in mammalian cells
31. CpG methylation, chromatin structure and gene silencing - A three-way connection
32. DNA methylation and genomic imprinting
33. Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor
34. Genomic imprinting: Parental influence on the genome
35. Parental imprinting: Potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene
36. Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal
37. Molecular analysis of the GCF gene identifies revisions to the cDNA and amino acid sequences
38. Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not non imprinted genes