Genetic imprinting: Silencing elements have their say

Current Biology

Volumn 10, Issue 23, 2000, Pages

  Ferguson Smith, Anne C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE SILENCING; GENETIC REGULATION; MOUSE; PROTEIN DOMAIN; SILENCING ELEMENT; SOMATOMEDIN BINDING PROTEIN;

RODENTIA;

EID: 0034735911     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00817-4     Document Type: Review

References (16)

1. Genomic imprinting in mammals: An interplay between chromatin and DNA methylation?
2. Transcriptional control: Imprinting insulation
3. The sins of the fathers and mothers: Genomic imprinting in mammalian development
4. A transcriptional insulator at the imprinted H19/Igf2 locus
5. Comparative genomic sequencing identifies novel tissue-specific enhancers and sequence elements for methylation-sensitive factors implicated in Igf2/H19 imprinting
6. Appropriate expression of the mouse H19 gene utilises three or more distinct enhancer regions spread over more than 130 kb
7. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2
8. H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis-acting regulatory element upstream of H19
9. Deletion of a silencer element in the Igf2 gene results in loss of imprinting independent of H19
10. A skeletal muscle-specific mouse Igf2 repressor lies 40kb downstream of the gene
11. Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch
12. Genomic regions regulating imprinting and insulin-like growth factor-II promoter 3 activity in transgenics: Novel enhancer and silencer elements
13. A 5' 2 kb region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development
14. Parental-origin-specific epigenetic modification of the mouse H19 gene
15. Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2
16. Parental imprinting: Potentially active chromatin of the repressed maternal allele of the mouse Igf2 gene